Midazolam chemical structure
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Versed

Midazolam, also known by the trade names Versed®, Hypnovel® and Dormicum®, is a benzodiazepine drug with an imidazole structure. Used commonly as an anxiolytic, amnestic, hypnotic and sedative, this medication provides an effect similar to diazepam, but with a quicker onset and shorter duration. It was first synthesized in 1976 by Fryer and Walser. more...

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This medication is frequently used (often in combination with other agents) by anesthesiologists for sedating patients prior to surgery, as well as for other invasive medical procedures such as colonoscopy.

Unlike other benzodiazepines such as diazepam and lorazepam, midazolam is water soluble as the imidazole ring is open at low pH. When it is in a solution with a pH greater than 4, the imidazole ring closes and it becomes much more lipid soluble, facilitating its rapid uptake into nerve tissue. This partly accounts for its rapid onset of action and its high protein binding in the blood (up to 97%).

Midazolam is a Schedule IV drug under the Convention on Psychotropic Substances. This drug is considered quite addictive , as expected given its potent anxiolytic properties and rapid onset of action. For these reasons, it is rarely prescribed outside hospital environments.

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U.S. archbishop named as doctrinal guardian
From Christian Century, 5/31/05

Pope Benedict XVI has named the archbishop of San Francisco, William Levada, to the pope's old job as guardian of the Catholic faith, making Levada the highest-ranking American ever to serve at the Vatican.

Levada, 68, was named May 13 prefect of the Congregation for the Doctrine of the Faith, a powerful post that Benedict himself held for nearly a quarter-century until his election as pope on April 19. The new theology czar has had a long friendship with the pope from the time (1976-1982)when Levada was a staffer at the doctrinal office.

Church observers say the choice of Levada--doctrinally conservative, a veteran of church bureaucracy and versed in the 21st-century social trends confronting the church--is a clear sign that Benedict intends to steer a traditional course while also engaging the world.

Levada, who was archbishop of the Portland (Oregon) archdiocese before moving to the San Francisco archdiocese in 1995, at times has shown a pragmatic streak. "Archbishop Levada is conservative in his approach to theological issues, but he seems to take care to explain his own positions carefully and without rancor," said Richard McBrien of the University of Notre Dame.

COPYRIGHT 2005 The Christian Century Foundation
COPYRIGHT 2005 Gale Group

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