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Versed

Midazolam, also known by the trade names Versed®, Hypnovel® and Dormicum®, is a benzodiazepine drug with an imidazole structure. Used commonly as an anxiolytic, amnestic, hypnotic and sedative, this medication provides an effect similar to diazepam, but with a quicker onset and shorter duration. It was first synthesized in 1976 by Fryer and Walser. more...

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This medication is frequently used (often in combination with other agents) by anesthesiologists for sedating patients prior to surgery, as well as for other invasive medical procedures such as colonoscopy.

Unlike other benzodiazepines such as diazepam and lorazepam, midazolam is water soluble as the imidazole ring is open at low pH. When it is in a solution with a pH greater than 4, the imidazole ring closes and it becomes much more lipid soluble, facilitating its rapid uptake into nerve tissue. This partly accounts for its rapid onset of action and its high protein binding in the blood (up to 97%).

Midazolam is a Schedule IV drug under the Convention on Psychotropic Substances. This drug is considered quite addictive , as expected given its potent anxiolytic properties and rapid onset of action. For these reasons, it is rarely prescribed outside hospital environments.

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New top gov't spokesman well-versed in foreign policy
From Japan Policy & Politics, 10/30/00

TOKYO, Oct. 27 Kyodo

Yasuo Fukuda, who has replaced scandal-hit Hidenao Nakagawa as the chief cabinet secretary, is well-versed in foreign policy, as he once served as parliamentary vice minister in the Foreign Ministry and headed the Foreign Affairs Division of the ruling Liberal Democratic Party (LDP).

Fukuda, a 64-year-old businessman-turned-politician, is the eldest son of the late Prime Minister Takeo Fukuda. While serving as a secretary to his father, Fukuda worked with Prime Minister Yoshiro Mori when Mori was a deputy chief cabinet secretary.

Despite never having held a cabinet post, Fukuda was handpicked for his current job to support the cabinet just as it is being rocked by scandals surrounding Nakagawa, the prime minister's closest aide.

Fukuda's selection was made after an LDP faction led by Mori but run by former Health and Welfare Minister Junichiro Koizumi reviewed Fukuda's ''personality, talent and experience.''

Fukuda is known for his calm and trustworthy character.

A graduate of Waseda University, also Mori's alma mater, he became his father's secretary after working for an oil company for 17 years. He was born in Tokyo but was elected to the House of Representatives four times from a constituency in Gunma Prefecture, north of Tokyo.

He also heads the Japan-Sri Lanka Association, based in Tokyo.

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