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Zafirlukast

Zafirlukast is an oral leukotriene receptor antagonist (LTRA) for the maintenance treatment of asthma. Available as a tablet, it blocks the action of leukotriene C4 on its receptors, thus reducing constriction of the airways, build-up of mucus in the lungs and inflammation of the breathing passages.

Zafirlukast is marketed by AstraZeneca with the brand names Accolate, Accoleit, and Vanticon. It was the first LTRA to be marketed in the USA and is now approved in over 60 countries, including the UK, Japan, Italy, Spain, Canada, Brazil and China.

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Chronic urticaria: add zafirlukast. (Combination Regimen).(combination drug therapy cures hives quickly)(Brief Article) : An article from: Skin & Allergy News $5.95 Hepatic failure reports added to label of leukotriene inhibitor zafirlukast: FDA MedWatch report.(Rx) : An article from: Family Practice News $5.95
Zafirlukast plus antihistamine in IgE-receptor-positive hives. (Clinical Rounds: For resistant cases).(Brief Article) : An article from: Internal Medicine News $5.95 Asthma drug's label gets hepatotoxicity warning.(Across Specialties) : An article from: Clinical Psychiatry News $5.95
Hepatic failure reports added to Zafirlukast label.(Rx)(Brief Article) : An article from: Internal Medicine News $5.95

Zafirlukast treatment in patients with acute asthma
There are 2 million emergency department visits and almost 500,000 hospital admissions annually in the United States because of acute asthma. Most patients ...
From American Family Physician, 10/1/05 by Karl E. Miller
High-dose zafirlukast in emergency department provides small benefit in acute asthma
Silverman RA, Nowak RM, Korenblat PE, et al. Zafirlukast treatment for acute asthma. Chest 2004; 126:1480-1489. * Clinical Question Does high-dose ...
From Journal of Family Practice, 4/1/05
Zafirlukast treatment for acute asthma : evaluation in a randomized, double-blind, multicenter trial
Context: Acute asthma causes nearly 2 million hospital emergency department (ED) visits in the United States annually, and hospitalization after an ED visit and relapse after ED discharge are commo
From CHEST, 11/1/04 by Robert A. Silverman
Fluticasone Propionate Compared with Zafirlukast in Controlling Persistent Asthma
A Randomized Double-Blind, Placebo-Controlled Trial * OBJECTIVE The objective of our study was to compare the efficacy and safety of fluticasone propionate ...
From Journal of Family Practice, 7/1/01 by William Busse
Effect Of Fluticasone Propionate And Zafirlukast On Exacerbation Rates And Clinical Outcomes In Low To High Users Of Rescue Albuterol - Statistical Data
Kathleen Rickard, MD*; Lisa Edwards, PhD and Christopher Kalberg, PhD. PURPOSE: Rescue albuterol use is a useful measure of asthma control and disease ...
From CHEST, 10/1/00 by Kathleen Rickard
Zafirlukast Reduces Relapses And Treatment Failures After An Acute Asthma Episode - Abstract
Purpose: To evaluate the effects of zafirlukast on emergency department (ED) discharges and relapses following discharge in patients presenting with ...
From CHEST, 10/1/99 by Robert A Silverman
Cost Effectiveness Of Inhaled Fluticasone Versus Zafirlukast In Patients Switched From Low Dose Inhaled Corticosteroids - Abstract
Purpose: Compare cost-effectiveness between fluticasone (FP) 88mg twice daily with oral zafirlukast (ZAF) 20mg twice daily in the treatment of asthma.
From CHEST, 10/1/99 by Richard Stanford
Effect Of Switching Patients With Asthma From Low-Dose Inhaled Corticosteroid Therapy To Low-Dose Fluticasone Or Zafirlukast - Abstract
Purpose: To evaluate asthma control in patients switched from a fixed dose of beclomethasone (BDP) or triamcinolone (TAA) to low-dose fluticasone propionate ...
From CHEST, 10/1/99 by Kathleen A Rickard

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