Chemical structure of stavudine.
Find information on thousands of medical conditions and prescription drugs.

Zerit

Stavudine (2'-3'-didehydro-2'-3'-dideoxythymidine, d4T, brand name ZeritĀ®) is a nucleoside analog reverse transcriptase inhibitor (NARTI) active against HIV. more...

Home
Diseases
Medicines
A
B
C
D
E
F
G
H
I
J
K
L
M
N
O
P
Q
R
S
T
U
V
W
X
Y
Z
Zafirlukast
Zagam
Zalcitabine
Zaleplon
Zanaflex
Zanamivir
Zantac
Zarontin
Zelnorm
Zerit
Zestoretic
Zestril
Zetia
Zevalin
Ziagen
Zidovudine
Zileuton
Ziprasidone
Zithromax
Zocor
Zofran
Zoladex
Zoledronic acid
Zolmitriptan
Zoloft
Zolpidem
Zometa
Zomig
Zonegran
Zonisamide
Zopiclone
Zosyn
Zovia
Zovirax
Zyban
Zymar
Zyprexa
Zyrtec
Zyvox

History

Stavudine was approved by the Food and Drug Administration (FDA) in Jun 24, 1994 for adults and in Sep 6, 1996 for pediatric use and again as an extended-release version for once-a-day dosing in 2001. The fourth antiretroviral drug on the market, its patent will expire in the United States on 2008-06-25.

Mechanism of ation

Stavudine is an analog of thymidine. It is phosphorylated by cellular kinases into active triphosphate. Stavudine triphosphate inhibits the reverse transcriptase by competing with natural substrate, thymidine triphosphate. It also causes termination of DNA synthesis by incorporating into it.

The oral absorption rate of stavudine is over 80 %. Approximately half of stavudine is actively secreted unchanged into the urine and the other half is eliminated through endogenic pathways. Simultaneous use of AZT is not recommended, for AZT can inhibit the intracellular phosphorylation of stavudine. Other anti-HIV drugs do not possess this property. The main severe side effect is peripheral neuropathy, which can be corrected by reducing dosage. Stavudine has been shown in laboratory test to be genotoxic, but with clinical doses its carcinogenic effects are non-existent.

Read more at Wikipedia.org


[List your site here Free!]


IN BRIEF
From International Family Planning Perspectives, 12/1/03 by Lane, Trevor

* Africa has now begun to manufacture generic AIDS drugs. The South African company Aspen Pharmacare announced it is producing antiretrovirals containing stavudme-the generic version of Bristol-Meyers Squibb's Zerit. One month's supply will cost 20-40% less (depending on the dose) than the nongeneric drug in South Africa. [Nessman R, South African company begins production of first generic AIDS drugs in Africa, Associated Press, Aug. 7, 2003, , accessed Aug. 18, 2003.]

* The Johns Hopkins Bloomberg School of Public Health/Center for Communication Programs and the Advocacy for Population Program have launched a Spanish-language Web site for adolescents, called Entra en Accion (Act Now). In addition to providing information on health and sexuality, the site covers topics such as nutrition, democracy, drug and alcohol prevention, vocational training and life skills. It also includes an online counseling service and links to youth organizations. The Web site can be found at .

* The Emergency Contraception Website has now been translated into Arabic. The site, created by the Association of Reproductive Health Professionals, Ibis Reproductive Health and the Office of Population Research at Princeton University, is a referral service (within the United States and Canada) as well as an educational source, and it includes a searchable database of contraceptives available worldwide that can be used for emergency contraception. Users can visit the Arabic version at or through the main site at .

Copyright Alan Guttmacher Institute Dec 2003
Provided by ProQuest Information and Learning Company. All rights Reserved

Return to Zerit
Home Contact Resources Exchange Links ebay