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Zevalin

Ibritumomab tiuxetan, also sold under the trade name ZevalinĀ® is a monoclonal antibody radioimmunotherapy treatment for some forms of non-Hodgkin's lymphoma, a myeloproliferative disorder of the lymphatic system. This drug uses the parent mouse antibody to Rituxan (another treatment for lymphoma) call tositumomab, and adds it to radioactive isotopes Yttrium (Y-90) or Indium (In-111). The antibody binds to the CD20 antigen found on the surface of B cells, letting radiation from isotope (mostly beta emittion) to kill that cell and some surrounding cells. This eliminates B cells (including the cancerous ones) from the body, allowing a new population of healthy B cells to develop from lymphoid stem cells. more...

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Administered by intravenous infusion which usually lasts around 10 minutes. Treatment with Zevalin (which also includes Rituxan) showed higher response rates in clinical trials compared to treatment with only Rituxan, and showed very promising results for patients who no longer respond to Rituxan.

Developed by the IDEC Pharmaceuticals Corporation, which is now part of Biogen Idec, Ibritumomab Tiuxetan was the first radioimmunotherapy drug approved by the FDA in 2002 to treat cancer.

Also see Bexxar, another monoclonal antibody radioimmunotherapy treatment of non-Hodgkin's lymphoma.

Read more at Wikipedia.org


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Syringe pump
From Healthcare Purchasing News, 5/1/04

The Graseby Medical 3400 Syringe Pump infuses commonly used nuclear medicine IV drugs such as Aadenosine, Dobutamine, Dipyridamole and Cholecystokinan. The pump is also designed to safely infuse recently FDA-approved radioactive therapy agents Zevalin[R] and Bexxar[R], which both require lengthy infusions. The Graseby Syringe Pump has a wide infusion rate range from 0.1-1200ml/hr, multiple unit selection, syringe size flexibility, AC or battery operation and possesses an accuracy rate of +/- 2%.

Cardinal Health Circle 112 or visit www.ksrleads.com/?405hp-112

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