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Zometa

Zoledronate (Zometa®, Novartis) is a bisphosphonate, used to prevent osteoporosis and skeletal fractures, particularly in patients with cancers such as multiple myeloma and prostate cancer. It can also be used to treat hypercalcemia, particularly hypercalcemia of malignancy. It can also be helpful for treating pain from bone metastases. more...

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Administration

Usually 4 mg intravenously once a month when given for oncologic purposes. It is given once a year for treatment of osteoporosis.

Side effects

Side effects can include fatigue, anemia, muscle aches, fevers, and swelling in the feet or legs. Zoledronate can cause deterioration in renal function.

A rare complicaiton of zoledronate is osteonecrosis of the jaw. This has mainly been seen in patients with multiple myeloma treated with zoledronate (Durie et al 2005).

Contraindications

Poor renal function (e.g. creatinine>3 mg/dL)
Pregnancy

Reference

Durie BG, Katz M, Crowley J. Osteonecrosis of the jaw and bisphosphonates. N Engl J Med 2005;353:99-102. PMID 16000365.

Read more at Wikipedia.org

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ADVISORY/FDA Approves Novartis Agent ZOMETA For Treatment of Hypercalcemia of Malignancy
From Business Wire, 8/21/01

Business Editors & Health/Medical Writers

ADVISORY...for TUESDAY (Aug. 21)

NOTE TO EDITORS: Multimedia Assets Available With This Story

Include Logos, Text News Releases, Video

--(BUSINESS WIRE)

Novartis announced it has received marketing approval from the U.S. Food and Drug Administration (FDA) for ZOMETA(R) (zoledronic acid for injection; zo MET uh), a new generation intravenous (IV) bisphosphonate for the treatment of hypercalcemia of malignancy (HCM).

HCM is the most common life-threatening metabolic complication associated with cancer. Video news release available here.

You can reach the story directly by going to http://www.newstream.com/cgi-bin/display_story.cgi?3756

This multimedia news story is for free and unrestricted use on your news information site (and for print or broadcast too). Visit http://www.newstream.com to download video, audio, text, graphics and photos.

If you have any questions about the story, or about Newstream.com, please write to us at info@newstream.com.

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