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Rasburicase is a recombinant urate oxidase enzyme. It is used for the prevention and treatment of tumor lysis syndrome in patients receiving chemotherapy for hematologic cancers such as leukemias and lymphomas.

It catalyses the conversion of uric acid to allantoin. Allantoin is much more soluble than uric acid, so renal excretion is more effective.

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2002 biotech drug launches
From Drug Cost Management Report, 2/1/03

The FDA has approved 20 new biotechnology-based drugs and vaccines as well as 15 new indications for previously approved biotech products in 2002.

According to the Biotechnology Industry Organization (BIO), this number is up slightly from 2001, and more than half of the 168 biotech medicines available today were approved in just the last five years. Of the 35 FDA approvals issued last year, 20 were for new medicines designed to treat such diseases as osteoporosis, hepatitis C, pulmonary arterial hypertension, cancer and multiple sclerosis.

Information: Kathy Stover, BIO, (202) 962-9200 or FDA, 888-INFO-FDA.

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