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Enflurane

Enflurane (2-chloro-1,1,2,-trifluoroethyl-difluomethyl ether)is a halogenated ether that was commonly used for inhalational anesthesia during the 1970s and 1980s. Developed by Ross Terrell in 1963, it was first used clinically in 1966. more...

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Enflurane is a structural isomer of isoflurane. It vaporizes readily, but is a liquid at room temperature.

Clinically, enflurane produces a dose-related depression of myocardial contractility with an associated decrease in myocardial oxygen consumption. Between 2% and 5% of the inhaled dose is oxidised in the liver, producing fluoride ions and difluoromethoxy-difluoroacetic acid. This is significantly higher than the metabolism of its structural isomer isoflurane.

Physical properties

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	Enflurane (Ethrane): A compendium and reference	Enflurane: Selected proceedings of the sixth European Congress of Anaesthesiology, London, September 8-15, 1982 : mit Zusammenfassungen in Deutsch


Interaction between artificial membranes and enflurane, a general volatile anesthetic: DPPC-enflurane interaction ABSTRACT The structural modifications of the dipalmitoylphosphatidylcholine (DPPC) organization induced by increasing concentration of the volatile anesthetic ... From Biophysical Journal, 5/1/03 by Hauet, Nathalie

Biological monitoring of occupational exposure to enflurane in operating room personnel - ethrane Biological monitoring of occupational exposure to enflurane (ethrane) can be achieved by measuring concentrations of inorganic fluorides in the blood and ... From Archives of Environmental Health, 3/1/94 by Marcello Imbriani

Transient neuromuscular impairment resulting from prolonged inhalation of halothane and enflurane Inhalation anesthesia first with halothane followed by enflurane relieved a patient with status asthmaticus who was refractory to conventional therapy ... From CHEST, 10/1/90 by Toshimori Tanigaki

Comfortably numb: anesthetics are slowly giving up the secrets of how they work Take a stroll through the Boston Public Garden, the nation's oldest botanical garden, and you'll find an array of plaques, monuments, and memorials honoring famous people of history. Not far from a From Science News, 7/3/04 by John Travis

An Isothermal Titration Calorimetry Study on the Binding of Four Volatile General Anesthetics to the Hydrophobic Core of a Four-[alpha]-Helix Bundle Protein ABSTRACT A molecular understanding of volatile anesthetic mechanisms of action will require structural descriptions of anesthetic-protein complexes. Previous ... From Biophysical Journal, 11/1/03 by Zhang, Tao

Mouse model of airway remodeling We found that continuous eosinophilic inflammation after repeated antigen instillation into the nose was observed only in A/J mice, not in three other ... From American Journal of Respiratory and Critical Care Medicine, 10/15/03 by Shinagawa, Kazuhiko

Letters to the editor To the Editor: The Oxford Miniature Vaporizer (OMV) 50 and the Ohmeda Portable Anesthesia Complete (PAC) are the modern draw-over anesthetic vaporizers ... From Military Medicine, 5/1/03

Physiology of the aerodigestive system and aberration in that system resulting in aspiration ABSTRACT. Background: Aspiration pneumonia remains a significant and often devastating problem in critically ill patients. It is unclear whether aspiration ... From JPEN: Journal of Parenteral and Enteral Nutrition, 11/1/02 by DeMeo, Mark T

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