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Enulose

Lactulose (Generlac®, Cholac®, Constilac®, Enulose®, Acilac®) is a synthetic sugar used in the treatment of constipation and liver disease. It consists of the monosaccharides fructose and galactose. more...

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Constipation

In the treatment of chronic constipation, its metabolites draw water into the bowel, causing a cathartic effect through osmotic action.

Hepatic encephalopathy

In treating hepatic encephalopathy, lactulose helps "draw out" ammonia (NH₃) from the body. The effectiveness of lactulose is somewhat controversial, and whether or not its effects are through ammonia is also controversial as well. Lactulose is metabolized in the colon by bacterial flora to short chain fatty acids, acidifying the colonic contents. This favors the formation of the nonabsorbable NH₄⁺ from NH₃, trapping NH₃ in the colon and effectively reducing plasma NH₃ concentrations.

Bowel Withholding

Lactulose can be used to treat children that withhold their bowel movements out of fear. The usual dosage is 1 tsp. for each year of the child's age, up to 30 ml. Mixed with juice, it is undetectable and works within four hours.

Side effects

Side effects include diarrhea and resultant dehydration and high sodium levels. In rare cases or with excess amounts can cause stomach pain, gas, vomiting, or diarrhea.

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1990 DrSN guide to generic companies - Drug Store News - Inside Pharmacy - directory
From Drug Store News, 1/22/90

1990 DrSN guide to generic companies

The recent generic scandal at FDA has shaken the industry and left many retailers with questions about many generic companies. As a service to our readers, Drug Store News/Inside Pharmacy contacted all the major generic companies and asked them to fill out a questionnaire that lists important information about their company. What follows is the information gleaned from the survey.

American Therapeutics Carlough Road, Bohemia, NY 11716, tel: (516) 563-1830.

* Leading executives: Vish G. Raju, vp of finance; Leroy Lunder, director of quality assurance; Susan Barrett, director of sales. * Industry contact: Susan Barrett, director of sales. * Annual sales: $24 million. * Toll-free customer service number: (800) 648-4445. * FAX number: (516) 563-4984. * Product catalog: Published twice a year. * Leading products: Danazol caps 200mg; Thiothixene caps 1mg, 2mg, 5mg, 10mg, 20mg; Trazodone tabs 50mg, 100mg; Triamterene/HCT tabs 75mg, 50mg; Clorazepate tabs 3.75mg, 7.5mg, 15mg. * National market coverage? Yes. * % of product line manufactured by company: 100%. * Payment terms: 1/10, net 30.

Barr Laboratories, Inc. 2 Quaker Road, Pomona, NY 10970, tel: (800) 222-0190.

* Leading executives: Edwin A. Cohen, CEO; Louis J. Guerci, CFO; Michael A. Ennis, vp of sales. * Industry contact: Kathleen McGee, vp of trade and professional relations. * Annual sales: $69 million. * Toll-free customer service number: (800) 222-4043. * FAX number: (914) 362-1193. * Product catalog: Publish once a year. * Leading products: Erythromycin granules 200 mg/600 mg, 100ml/150ml/200ml; Hydrocone 5/500mg, 100s/500s; Erythromycin 400mg, 100s/500s/1000s; Codeine 30/300mg, 100s/1000s; Oxycodone 5/325mg, 100s/500s. * National market coverage: Yes. * % of product line namufactured by company: 100%. * Payment terms: Net 30.

Barre-National Inc. 7205 Windsor Blvd., Baltimore, MD 21207, tel: (301) 298-1000.

* Leading executives: Max Mendelsohn, president; Tom Mendelsohn, senior vp; Ed Midgett, vp of prescription products. * Industry contact: Max Mendelsohn, president. * Annual sales: $65 million. * Toll-free customer service number: (800) 638-9096. * FAX number: (301) 298-6343. * Product catalog: Published twice a year. * Leading products: Constulose & enulose 8oz, 16oz, 32oz, 64oz; Sulfatrim 100ml, pt; Erythromycin Ethlysuccinate 200mg, 400mg, 100ml, pt; Iophen DM 4oz, pt, gal; Iophen C 4oz, pt, gal. * National market coverage: Yes. * % of product line manufactured by company: 95%. * Payment terms: 10 net 30.

Biocraft Laboratories, Inc. 92 Route 46, Elmwood Park, NJ 07407, tel: (800) 631-0165.

* Leading executives: Harold Snyder, president/CEO; Gerald Moskowitz, vp of sales; Sherrie M. Bradley, director of sales and marketing. * Industry contact: Sherrie M. Bradley, director of sales and marketing. * Annual sales: $84,905. * Toll-free customer service number: (800) 631-0165. * FAX number: (201) 796-1434. * Product catalog: Published once a year. * Leading products: Not supplied * National market coverage: Yes. * % of product line manufactured by company: 100% * Payment terms: 1/10, net 30

Bolar Pharmaceutical Co., Inc. 33 Ralph Avenue, P.O. Box 30, Copiague, NY 11726, tel: (516) 842-8383

* Leading executives: Robert Shulman, president; Jack Rivers, executive vp; Lawrence Raisfield, secretary/treasury. * Industry contact: Karen S. Sattig, director of sales. * Annual sales: $127 million. * Toll-free customer service number: (800) 872-0159. * FAX number: (516) 842-8630. * Product catalog: Published once a year. * Leading products: Triamterene/HCT 50/25mg caps; Nitro Trans System 5mg/24hrs (Patch); Quinidine Gluconate 324mg SR tablets; Phenytoin Sodium 100mg extend caps; Carisoprodol Compound Tabs. * National market coverage: Yes. * % of product line manufactured by company: 99% * Payment terms: Net 30 FOB dest.

Copley Pharmaceutical Inc. 25 John Road, Canton Commerce Center, Canton, MA 02021, tel: (617) 821-6111.

* Leading executives: Jane C. Hirsh, president; Barbara L. Morse, CEO; Steve Tannenbaum, CFO. * Industry contact: Julie Trendowicz, sales manager. * Annual sales: $20 million. * Toll-free customer service number: (800) 325-6111. * FAX number: (617) 821-4068. * Product catalog: Published once a year. * Leading products: Potassium chloride 8mg; Brompheril SR (equivalent to Drixoral); Bromatapp (equivalent to Dimetapp); Doxylamine Succinate 25mg; K-Electrolyte eff. tablets. * National market coverage: Yes. * % of product line manufactured by company: 100% * Payment terms: Net 30 days.

Duramed Pharmaceuticals, Inc. 5040 Lester Road, Cincinnati, OH 45213, (513) 731-9900.

* Leading executives: E. Thomas Arington, chairman, president, CEO; Bruce G. Briggs, vp of corporate development; Jeffrey T. Arington, vp of sales and marketing. * Industry contact: E. Thomas Arington, chairman, president, CEO. * Annual sales: $25 million. * Toll-free customer service number: (800) 543-8338. * FAX number: (513) 731-5270. * Product catalog: Published once a month. * Leading products: Conjugated Estrogens tablets 2.5mg, 100s; Propranolol HCl tablets 90mg, 100s; Methyldopa tablets 500mg, 100s/500s. * National market coverage: Yes. * % of product line manufactured by company: 80%. * Payment terms: 2% 30, net 31.

Forest Inwood Labs 150 East 58th Street, New York, N.Y. 10155, (212) 421-7850.

* Leading executives: Howard Solomon, president and CEO; Ken Goodman, vp of finance; Phil Satow, executive vp of sales and marketing. * Industry contact: Brian Smith, product manager. * Annual sales: $140 million. * FAX number: (800) 326-6260. * Product catalog: Published twice a year. * Leading products: Indomethacin E.R. 75mg 60s/100s; Propranolol E.R. 60mg 100s/500s/1000s; Isosorbibe C.R. 40mg 100s/1000s. * National market coverage: Yes. * % of product line manufactured by company: 100%. * Payment terms: Net 30 days.

E. Fougera & Co., Div. Atlanta Inc. 60 Baylis Road, Melville, NY 1174 tel: (516) 454-6996.

* Leading executives: Rolf Rahmstorff, president; Kevin Sheil, vp of sales; Art Dulik, vp of finance. * Industry contact: Stuart Schansinger, business development manager. * Annual sales: $50 million. * Toll-free customer service numbers: (800) 645-9833/426-6483. * FAX number: (516) 420-1572/(714) 594-0220. * Product catalog: Published once a year. * Leading products: Surgilube lubricating jelly; Hydrocortisone 1% cream & ointment; Nystatin oral suspension; Nitroglycerin ointment; Erythromycin ophthalmic ointment. * National market coverage: Yes. * % of product line manufactured by company: 100%. * Payment terms: 2%-30 days (from date of invoice)/net 45.

Genetco Inc. 1 Baiting Place Road, Farmingdale, NY 11735, tel: (516) 293-2214.

* Leading executives: Carol Reinbold, president; Thomas Manning, vp of sales; Joseph Anzalane, manager of operations/warehouse. * Industry contact: Carol Reinbold, president. * Annual sales: $12 million. * Toll-free customer service number: (800) 233-0069. * FAX number: (516) 293-1760. * Product catalog: Published 4 times a year. * Leadingproducts: Acetaminophen w/codeine #3 M's; Dipyridamole 25mg tablets M's; Nystatin suspension 60ml; Hydrocortisone Cream 1% 30gm; Cephalexin Capsules 250mg. * National market coverage? Yes. * % of product line manufactured by company: 0%. * Payment terms: 1/10, net 11.

G&W Laboratories, Inc. 111 Coolidge Str., South Plainfield, NJ 07080, (201) 753-2000.

* Leading executives: Burton Greenblatt, president; Dr. A.N. Rao, executive vp; Ronald Greenblatt, vp of finance & administration. * Industry contact: Joseph W. Freeman, director of sales & marketing. * Toll-free customer service number: (800) 922-1038. * FAX number: (201) 753-9264. * Product catalog: Published once a year. * Leading products: Glycerin suppositories; Acephen/Acetaminophen suppositories 120mg; Formulation R suppositories/ointment; Anucort HC 25mg suppositories; Tebamide 200mg suppositories. * National market coverage: Yes. * % of product line manufactured by company: 100%. * Payment terms: Net 30.

Lexis Pharmaceuticals, Inc. 100 Congress Ave., Suite 400, Austin, TX, 78701, (512) 474-8484.

* Leading executives: John D. Bryer, president & CEO; Al McConnell, vp of market development; Gary D. Waters, vp of marketing & sales. * Industry contact: Al McConnell, vp of market development. * Annual sales: $3.6 million. * Toll-free customer service number: (800) 458-7455. * FAX number: (512) 474-5347. * Product catalog: Published only when new products or prices are announced. * Leading products: N.E.E. 1/35 28 days; N.E.E. 1/35 21 days; Span-FF Iron supplement; Histamic capsules; Furonatal pre-natal vitamins. * National market coverage: Yes. * % of product line manufactured by company: 0%. * Payment terms: 2% 10, Net 30 to wholesalers.

Logen Pharmaceutical, Inc. 120 Secatogue Ave., Farmingdale, NY 11735, tel: (800) 252-8890.

* Leading executives: William Van Aalten, president & CEO; David Winchell, vp of sales & marketing; Sandy Schreiber, national sales manager. * Industry contact: David Winchell, vp of sales & marketing. * Annual sales: $10 million. * Toll-free customer service number: (800) 252-8890. * FAX number: (516) 293-2095. * Product catalog: Published 4 times a year. * Leading products: Ampicillin 500mg; Amoxicillin 500mg; Ibuprofen 600mg; APAP w/cod 30mg; Hydrochlorthiazide 50mg. * National market coverage: Yes. * % of product line manufactured by company: 0%. * Payment terms: Net 30.

Major Pharmaceutical Corp. 1640 W. Fulton Str., Chicago, IL 60612, tel: (312) 666-9600.

* Leading executives: Fred Bondy, president; Steve Strand, vp; Jeff Farber, vp. * Industry contact: Steve Strand, vp. * Annual sales: $130 million. * Toll-free customer service number: (800) 621-4179. * FAX number: (312) 666-8493. * Product catalog: Published once every two years. * Leading products: Cephalexin 500mg 500s; Acetaminophen w/codeine 1/2gr 1000s; Allopurinol 300mg 500s; Ibuprofen 600mg 500s; Propoxyphene Napsylate 100mg/650mg 500s. * National market coverage: Yes. * % of product line manufactured by company: 5%. * Payment terms: Net 30.

Mason Distributors, Inc. 5105 N.W. 159 Str., Hialeh, FL, 33014, tel: (800) 327-6005.

* Leading executives: Carlos J. Rodriguez, president; Caridad Gonzalez, executive vp; Paul Kimbar, vp of sales & marketing. * Industry contact: Paul KImbar, vp of sales & marketing. * Annual sales: $37 million. * Toll-free customer service number: (800) 327-6005. * FAX number: (305) 621-3944. * Product catalog: Published once a month. * Leading products: Ibuprofen 600mg 500s; Propoxyphene Napsylate 100mg 500s; APAP w/codeine 30mg 1000s; Furosemide 40mg 1000s; NTS Patches 5mg 30s. * National market coverage: Yes. * % of product line manufactured by company: 0%. * Payment terms: Net 30 days.

Moore Medical Corp. 389 John Downey Drive, New Britain, CT 06050, (203) 225-4621.

* Leading executives: Jerald K. Rome, chairman & CEO; Mark E. Karp, president & COO; John A. Murray, CFO. * Industry contact: Wayne A. Corona, pharmacist. * Annual sales: $250 million. * Toll-free customer service number: (800) 444-8765. * FAX number: (203) 223-2382. * Product catalog: Published once every three weeks. * Leading products: Cefadroxil capsules; Triamterene w/HCTZ Caps; Dipyridamole tablets; Quinidine Gluconate tablets; Ibuprofen tablets. * National market coverage: Yes. * % of product line manufactured by company: 0%. * Payment terms: Net 15 days.

Mutual Pharmaceutical Co. 1100 Orthodox Str., Philadelphia, PA 19124, tel: (800) 843-2178.

* Leading executives: Richard H. Roberts, CEO; Theodore H. Roberts, president; Maurice Maleh, senior executive vp of sales & marketing. * Industry contact: Maurice Maleh, senior executive vp of sales & marketing. * Annual sales: $30 million. * Toll-free customer service number: (800) 843-2178. * FAX number: (215) 288-6559. * Product catalog: Published once a year. * Leading products: Albuterol sulfate tablets 2mg 100s; Allopurinol tablets 300mg 100s; Verapamil white FC tablets 80mg 100s; Quinidine gluconate tablets 324mg 100s; Indomethacin lt. gr. capsules 50mg 500s. * National market coverage: Yes. * % of product line manufactured by company: 100%. * Payment terms: Net 30.

ParMed Pharmaceuticals, Inc. 4220 Hyde Park Blvd., Niagara Falls, NY 14305, (716) 284-5666.

* Leading executives: Dominick V. Palmo, vp/general manager; James W. Hillman, vp of direct marketing; James L. Grigg, vp of operations & development. * Industry contact: Irwin Wechsler, pharmacist. * Annual sales: $40 million. * Toll-free customer service number: (800) PARMED 1 (727-6331). * FAX number: (716) 284-8031. * Product catalog: Published once a month. * Leading products: Triamterene 50mg 1000s; Ibuprofen 800mg 500s; Propoxyphene Napsylate 100mg/APAP 1000s; Cephalexin 500mg caps 500s; APAP w/codeine 1/2gr 1000s. * National market coverage: Yes. * % of product line manufactured by company: 10%. * Payment terms: Net 30.

Par Pharmaceutical, Inc. One Ram Ridge Road, Spring Valley, NY 10977, tel: (914) 425-7100.

* Leading executives: Kenneth I. Sawyer, president/CEO; Jeffrey M. Levine, executive vp; Richard J. Nadler, vp of finance. * Industry contact: Jeffrey M. Levine, executive vp. * Annual sales: $100 million. * Toll-free customer service number: (800) 828-9393 * FAX number: (914) 425-7907 * Product catalog: Updated periodically. * Leading products: Ibuprofen; Perphenazine/Amitriptyline; Dipyridamole; Benztropine Mesylate; Flurazepam. * National market coverage: Yes. * % of the product line manufactured by company: 100%. * Payment terms: Net 30.

Pharmics, Inc. P.O. Box 27554, Salt Lake City, UT 84127-0554, tel:(801) 972-4138.

* Leading executives: Walter J. Plumb III, president; Paul H. Bagley, secretary, treasurer. * Industry contact: Paul H. Bagley, general manager. * Annual sales: $350,000. * Toll-free customer service number: (800) 456-4138. * FAX number: (801) 972-4139. * Product catalog: Published once a year. * Leading products: O-Cal fa tablets 100s; Pharmaflur (2.2mg sodium fluoride) 1000s; Ferrets 100s; Soluvite-F 57cc; O-Cal-ette Nursing Caps. * National market coverage: No. * % of products manufactured by your company: 0%. * Payment terms: 2% 10, Net 30.

Qualitest Products, Inc. 1025 Jordan Road, Huntsville, Al. 35811, tel:(205) 859-4011.

* Leading executives: William S. Propst, president; Charles (Trey) Propst, director of sales. * Industry contact: Charles (Trey) Propst, director of sales. * Toll-free customer service number: (800) 521-8151. * FAX number: (205) 859-4021. * Product catalog: Published four times a year. * Leading products: Amoxicillin 250mg; Penicillin VK 500mg; Theophylline 300mg; Nystatin drops; Imipramine 50mg. * National market coverage: Yes. * Payment terms: 1% 30, Net 31.

Sidmak Laboratories, Inc. 17 West Street, East Hanover, N.J. 07936, tel: (201) 386-5566.

* Leading executives: Dr. Satish Patel, president; Vin Bhalani, executive vp; Loken Patel, national sales manager. * Industry contact: Loken Patel, national sales manager. * Annual sales: $31 million. * Toll-free customer service number: (800) 922-0547. * FAX number: (201) 386-9817. * Product catalog: Published once every two years. * Leading products: Trazodone 150mg tabs; Desipramine 25-50mg; Dipyridamole 50-75mg; Salsalate 7 5 0 m g ; Sulfamethoxazole/Trimethoprim DS. * National market coverage: Yes. * % of product line manufactured by company: 100%. * Payment terms: 1% 10, Net 30.

Squibb Mark 105 Carnegie Center, Princeton, N.J., 08540, tel: (609) 987-6800.

* Leading executives: Thomas P. Luolam, president; Lee Burg, vp sales & marketing; Nanci T. Bachman, director of marketing. * Industry contact: Vincent Bilinsky, director of sales & trade operations. * Annual sales: $165 million. * Toll-free customer service number: (800) 332-2056. * FAX number: (609) 987-6863. * Product catalog: Published twice a year. * Leading products: Amoxicillin; Cephradine; Cephalexin; Penicillin VK; Penicillin G. * National Market Coverage: Yes. * % of product line manufactured by company: 95%. * Payment terms: Direct 2/10 Net Eom; Wholesalers 2% Net 31.

Steris Laboratories, Inc. P.O. Box 23160, 620 N. 51st Ave., Phoenix, Ariz. 85043, tel: (602) 278-1400.

* Leading executives: James C. McGee, president; Michael J. Blank, vp of marketing; Micahel S. Anderson, vp of sales. * Industry contact: Gail Bishop, customer servie manager. * Toll-free customer service number: (800) 692-9995. * FAX number: (602) 269-7468. * Product catalog: Published twice a year. * Leading products: Neo-Poly-HC Otic Suspension; Vitamin B-12 Injection 1000mcgm; Sodium Sulfacetamide 10% Ophthalmic Solution; Neo-Poly-Dex Ophthalmic Solution; Dexamethasone Acetate/Sodium Phosphate Injection. * National market coverage: Yes. * % of product line manufactured by company: 100%. * Payment terms: Net 30.

Taro Pharmaceuticals USA Inc. 49 Halstead Ave., Harrison, N.Y. 10528, tel: (800) 544-1449.

* Leading executives: Aaron Levitt, president; Peter Giallorenzo, vp; Alex Cossin, secretary treasurer. * Industry contact: Ben Maizel. * Annual sales: $3 million. * Toll-free customer service number: (800) 544-1449. * FAX number: (914) 381-4943. * Product catalog: Published twice a year. * Leading Products: Fluocinonide; Fluocinonide Emollient; Tramcinalone Acetonide Dental Paste; Carbamazepine; Betamethasone Valerate Cream. * National market coverage: Yes. * % of product line manufactured by company: 90%. * Payment terms: 2-30 Net 31.

United Research Laboratories, Inc. (URL) 4629 Adams Ave., Philadelphia, Penn. 19124, tel: (800) 523-3684.

* Leading executives: Richard H. Roberts, CEO; Theodore H. Roberts, president; Maurice Maleh, senior executive vp of sales & marketing. * Industry contact: Maurice Maleh, senior executive vp of sales & marketing. * Annual sales: $70 million. * Toll-free customer service number: (800) 523-3684. * FAX number: (215) 743-7486. * Product catalog: Published twice a year. * Leadingproducts: Acetaminophen w/Codeine 30mg tabs 100s; Sulfamethoxasole 800mg w/Trimethoprim 160mg tabs 500s; Niacin 250mg sustained release caps; Dipyridamole 50mg tabs 1000s; Allopurinol 300mg tabs 500s. * National market coverage: Yes. * % of products manufactured by company: 25%. * Payment terms: 2% 30, Net 31.

Vitarine Pharmaceuticals, Inc. 227-15 No. Conduit Ave., Springfield Gardens, N.Y. 11413, tel: (718) 276-8600.

* Leading executives: Roger W. Jordan, president; Seymour Hyden, vp of technical affairs; Barry Kaplan, executive vp of operations. * Industry contact: Clark E. Glabraith, vp of sales. * Annual sales: $10 million. * Toll-free customer service number: (800) 526-0225. * FAX number: (718) 949-3120. * Product catalog: Updated periodically. * Leading products: SMX-TMP DS; Nitroglycerin 6.5mg; SMX-TMP SS; Qunindine Sulfate 300mg; Nitroglycerin 2.5mg. * National market coverage: Yes. * % of products manufactured by company: 100%. * Payment terms: 2% 15 days, Net 30.

PHOTO : Peoples pharmacy in Alexandria, Va., urges customers to ask about generic drug savings.

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