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Estrace

Estradiol (17-beta estradiol) is a sex hormone. Labelled the "female" hormone but also present in males it represents the major estrogen in humans. Critical for sexual functioning, estradiol also supports bone growth. more...

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Synthesis

Estradiol, like other sex steroids, is derived from cholesterol. After side chain cleavage and either utilizing the delta-5 pathway or the delta-4 pathway androstenedione is the key intermediary. Androstendione is either converted to testosterone which in turn undergoes aromatization to estradiol, or, alternatively, androstendione is aromatized to estrone which is converted to estradiol.

Conversion of testosterone to estradiol:

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WISE WOMAN
From Friend Indeed, A, 11/1/04

I started having menopausal symptoms in my late 40s. Although I never had any hot flashes, I was experiencing vaginal dryness. I tried Replens, but it didn't seem to work. Ï also had sleeplessness and just wasn't feeling my self. I had always been a very energetic person and I was tired all the time, ? went to a naturopath and tried all the remedies like black cohosh, but they didn't help either. Meanwhile, I started feeling like I had a bladder infection all the time, although nothing came up on the tests. So my doctor put me on the estrogen ring [which is placed deep inside the vagina] to alleviate my vaginal dryness. But it was horrible and I couldn't get it out fast enough. That's when my gynecologist prescribed Premarin and progestin, a hormone replacement therapy formulation, ? remember the first day I took them - it was on my 50th birthday. I started feeling great right away - my sleeplessness and diyness cleared up almost immediately. I tootled along nicely for several years when suddenly I developed non-stop burning in my vagina. I went to ail the top doctors and all they could recommend is that I wear cotton underpants. They were concerned with vaginal care and weren't diagnosing the problem. Finally, I found a doctor who switched my hormone formulation to bio-identical hormones, Estrace and Prometrium. The burning stopped. I felt better again. Two years ago, when the large study came out about hormones causing breast cancer and heart disease, I hesitated about continuing. But for me, now 61 years old, it came down to quality of life. I decided to stay on, making sure that I watch my health. Every year, my doctor performs an internal exam, a vaginal ultrasound to monitor for uterine cancer, and a blood test for ovarian cancer. I do breast self-exams and receive three clinical breast exams and a mammogram yearly. As for my heart health, I make sure cholesterol and blood pressure tests are taken every year. They always come out perfectly. Once a day, I swallow a baby aspirin, I get regular bone scans - again, I've been told I have the bones of a young woman. Meanwhile, I sleep fabulously. When I wake up in the morning, I jump out of bed. My joints are limber. Frankly, for me, I don't see any reason to stop taking hormones. So far, so good. - B.G.

Copyright Initiatives for Women's Health, Inc. Nov/Dec 2004
Provided by ProQuest Information and Learning Company. All rights Reserved

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