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Nembutal

Pentobarbital is a barbiturate that is available as both a free acid and a sodium salt, the former of which is only slightly soluble in water and ethanol. One trade name for this drug is Nembutal®, coined by Dr. John S. Lundy, who started using it in 1930, from the structural formula of the sodium salt—Na (sodium) + ethyl + methyl + butyl + al (common suffix for barbiturates). more...

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Uses

Approved

  • seizures
  • sedation

Unapproved/Investigational/Off-Label

  • reduction of intracranial pressure in Reye's syndrome, traumatic brain injury.
  • induction of coma in cerebral ischemia patients

Veterinary medicine

In veterinary medicine sodium pentobarbital—traded under names such as Sagatal—is used as an anaesthetic,.

Euthanasia

It is used by itself, or more often in combination with complementary agents such as phenytoin, in commercial euthanasia injectable solutions. Trade names include Euthasol, Euthatal, Beuthanasia-D and Fatal Plus.

Metabolism

Pentobarbital undergoes first-pass metabolism in the liver and possibly the intestines.

Drug Interactions

Administration of alcohol, opioids, antihistamines, other sedative-hypnotics, and other central nervous system depressants will additively increase the sedation caused by pentobarbital.

Tricyclic antidepressants decrease serum levels of pentobarbital.

References and End Notes

  • DBGET Result: COMPOUND: C07422
  • Davis's Drug Guide for Nurses, Eighth Edition Copyright © 2005 by F.A. Davis Company
  1. ^  "Pentobarbital." San Diego Reference Laboratory: Technical Help.
  2. ^  Lee C. Fosburgh (1997). Imagining in Time: From this point in time: Some memories of my part in the history of anesthesia -- John S. Lundy, MD. American Association of Nurse Anesthetists Journal 65 (4): 323-8. PMID 9281913 AANA Archives-Library page List of Library Holdings Worldwide
  3. ^  Unknown. ANESTHESIA AND ANALGESIA. Animal Use Protocols. University of Virginia. URL accessed on 4 October 2005.
  4. ^  UBC Committee on Animal Care. Euthanasia. SOP 009E1 - euthanasia - overdose with pentobarbital. The University of British Columbia. URL accessed on 4 October 2005.
  5. ^  Knodell RG, Spector MH, Brooks DA, Keller FX, Kyner WT. "Alterations in pentobarbital pharmacokinetics in response to parenteral and enteral alimentation in the rat." Gastroenterology. 1980 Dec;79(6):1211-6. PMID 6777235


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Cut-off and toxicity levels for drugs-of-abuse testing
From Medical Laboratory Observer, 8/1/04

This table summarizes information useful in the interpretation of drugs-of-abuse assays. It was developed by Daniel M. Baer, MD, professor emeritus of pathology, Oregon Health Sciences University, Portland OR, and updated by Richard A. Paulson, MT(ASCP), supervisor of chemistry and toxicology, VA Medical Center, Portland, OR. The table was updated for CLR 2004-2005 by Robert H. Williams, PhD, DABCC, FACB, MT (ASCP), Clinical Scientist/Consultant, Quest Diagnostics, Inc. and Clinical Associate Professor of Pathology, University of South Florida, both in Tampa, FL.

COPYRIGHT 2004 Nelson Publishing
COPYRIGHT 2004 Gale Group

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