Tamoxifen chemical structure
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Nolvadex

Tamoxifen is an oral selective estrogen receptor modulator which is used in breast cancer treatment, and is currently the world's largest selling breast cancer treatment. It is used for the treatment of early and advanced breast cancer in pre- and post-menopausal women. It is also approved by the FDA for the reduction of the incidence of breast cancer in women at high risk of developing the disease. It has been further approved for the reduction of contralateral (in the opposite breast) breast cancer. more...

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Tamoxifen was invented by ICI Pharmaceuticals (now AstraZeneca) and is sold under the brand names Nolvadex, Istubal, and Valodex. It is also available as a generic drug in a number of countries. In the United States, the drug was almost always referred by its generic name, even before patent expiration.

A rare condition occasionally treated with tamoxifen is retroperitoneal fibrosis.

Tamoxifen is sometimes used to treat gynecomastia in men. Tamoxifen is also used by bodybuilders to try and prevent or reduce drug-induced gynecomastia caused by steroids.

4-hydroxytamoxifen

4-hydroxytamoxifen is a form of the drug tamoxifen that is made by the body after taking tamoxifen. It can also be made in the laboratory, and may help decrease breast density. A topical form of 4-hydroxytamoxifen is being studied in breast cancer screening.

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Deadly combos: taking prescription drugs and herbs together can be risky for your health. Here's what not to mix
From Shape, 3/1/05 by Mary Jane Horton

If you use popular herbal supplements, such as Saint Johnswort, echinacea or even garlic, take note: Combining them with prescription medications may threaten your health, according to recent studies. Drug/herb interactions can interfere with the effectiveness of everything from birth-control pills to antibiotics, and can even cause uncontrolled bleeding, liver damage and death. "People think herbs are 'natural,' so they must be safe. But that isn't always true, especially when they are combined with other substances," says Brent A. Bauer, M.D., director of the Complementary and Integrative Medicine Program at the Mayo Clinic in Rochester, Minn.

"We are just starting to learn about these interactions," Bauer says. "However, much of the information is theoretical, based on what we know about the actions of the drugs and the actions of the herbs."

The chart below details what we do know. For more information on herb-drug interactions, visit mayoclinic.com, herbmed.org and nccam.nih.gov.

Mary Jane Horton is a health writer in Pasadena, Calif., who avoids all supplements to ensure she won't mix the wrong ones.

COPYRIGHT 2005 Weider Publications
COPYRIGHT 2005 Gale Group

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