Tamoxifen chemical structure
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Nolvadex

Tamoxifen is an oral selective estrogen receptor modulator which is used in breast cancer treatment, and is currently the world's largest selling breast cancer treatment. It is used for the treatment of early and advanced breast cancer in pre- and post-menopausal women. It is also approved by the FDA for the reduction of the incidence of breast cancer in women at high risk of developing the disease. It has been further approved for the reduction of contralateral (in the opposite breast) breast cancer. more...

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Tamoxifen was invented by ICI Pharmaceuticals (now AstraZeneca) and is sold under the brand names Nolvadex, Istubal, and Valodex. It is also available as a generic drug in a number of countries. In the United States, the drug was almost always referred by its generic name, even before patent expiration.

A rare condition occasionally treated with tamoxifen is retroperitoneal fibrosis.

Tamoxifen is sometimes used to treat gynecomastia in men. Tamoxifen is also used by bodybuilders to try and prevent or reduce drug-induced gynecomastia caused by steroids.

4-hydroxytamoxifen

4-hydroxytamoxifen is a form of the drug tamoxifen that is made by the body after taking tamoxifen. It can also be made in the laboratory, and may help decrease breast density. A topical form of 4-hydroxytamoxifen is being studied in breast cancer screening.

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Zeneca to launch Nolvadex ads
From Drug Store News, 12/14/98

Zeneca will begin a direct-to-consumer advertising campaign for its breast cancer drug, Nolvadex (tamoxifen citrate), on television and in magazines starting early in 1999, and has started preparing physicians and pharmacists with educational materials and information on the drug, which was approved for the reduction of breast cancer in women at high risk for developing the disease. The Food and Drug Administration avoided the word prevention.

Zeneca officials have said their own market research tells them that women are likely to be cautious. The company targets the potential market for the drug at about 10 million women who are at high risk for developing the disease. Approximately 400,000 women already take tamoxifen because they have had breast cancer and are seeking to reduce the chance of a recurrence.

The largest breast cancer study to date, involving 22,000 women, will begin in early 1999. The NCI-funded study will compare Nolvadex with Lilly's osteoporosis drug, raloxifene (Evista) for reducing the incidence of breast cancer. Researchers are conducting the trial to see if the Lilly drug has fewer side effects than tamoxifen, which has been linked to increased risk of endometrial cancer.

COPYRIGHT 1998 Lebhar-Friedman, Inc.
COPYRIGHT 2000 Gale Group

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