Tamoxifen chemical structure
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Nolvadex

Tamoxifen is an oral selective estrogen receptor modulator which is used in breast cancer treatment, and is currently the world's largest selling breast cancer treatment. It is used for the treatment of early and advanced breast cancer in pre- and post-menopausal women. It is also approved by the FDA for the reduction of the incidence of breast cancer in women at high risk of developing the disease. It has been further approved for the reduction of contralateral (in the opposite breast) breast cancer. more...

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Tamoxifen was invented by ICI Pharmaceuticals (now AstraZeneca) and is sold under the brand names Nolvadex, Istubal, and Valodex. It is also available as a generic drug in a number of countries. In the United States, the drug was almost always referred by its generic name, even before patent expiration.

A rare condition occasionally treated with tamoxifen is retroperitoneal fibrosis.

Tamoxifen is sometimes used to treat gynecomastia in men. Tamoxifen is also used by bodybuilders to try and prevent or reduce drug-induced gynecomastia caused by steroids.

4-hydroxytamoxifen

4-hydroxytamoxifen is a form of the drug tamoxifen that is made by the body after taking tamoxifen. It can also be made in the laboratory, and may help decrease breast density. A topical form of 4-hydroxytamoxifen is being studied in breast cancer screening.

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Nolvadex approved for breast cancer use
From Drug Store News, 11/23/98 by Ellen R.Ph. Kim

The Food and Drug Administration has approved Zeneca's breast cancer drug Nolvadex (tamoxifen citrate) for the reduction of breast cancer incidences in women at high risk for developing the disease. The new indication makes Nolvadex the first and only drug to be approved for this indication. The FDA has also approved the drug for a second new indication, reduction of contraleteral breast cancer incidences. Current data from clinical trials were also added that support five years of adjuvant Nolvadex therapy for patients with breast cancer.

The FDA's actions are based on results from the Breast Cancer Prevention Trial, sponsored by the National Cancer Institute, which concluded that women taking Nolvadex reduced their incidence of developing invasive breast cancer on average by 44 percent. Updated results published in September concluded the incidence of invasive breast cancer was reduced by 51 percent in women aged 50-59 and 55 percent for women age 60 and older.

COPYRIGHT 1998 Lebhar-Friedman, Inc.
COPYRIGHT 2000 Gale Group

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