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Taurine

Taurine (from taurus = ox, as it was discovered in ox bile) or 2-aminoethanesulfonic acid is an acidic chemical substance found in bile which acts as an emulsifier for ingested lipids and assists in their absorption. Taurine may also come from synthetic materials. more...

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Chemistry

Chemically, it is a colorless crystalline substance with the empirical formula C2H7NO3S, formed by the hydrolysis of taurocholic acid or decarboxylation of cysteine. Taurine is found in the urine, as well as juices and fluids of muscle, lungs and nerve tissue of many animals, and plays several important roles in the body and is essential to newborns of many species. While it is often referred to as an amino acid, this is an inaccurate categorization since it does not contain any carboxylic acid functional groups.

Physiology and Pharmacology

Taurine has three major roles in human metabolism:

  • It plays a role in digestion. It is conjugated with the bile acids chenodeoxycholic acid and cholic acid to form (at the usually above 7 pH of bile) the bile salts, sodium taurochenodeoxycholate and sodium taurocholate (see bile).
  • It may assist in the formation of reactive oxygen species for the respiratory burst in neutrophil granulocytes
  • There is evidence that it is an inhibitory neurotransmitter in the central nervous system.

It has been linked to a number of other metabolic functions but its role is not clear.

Uses

It has been tested medically in the treatment of congestive heart failure, cystic fibrosis, diabetes, epilepsy and several other conditions with positive results. It is used by some as an neutralizer for monosodium glutamate . However, neither the harmfulness of monosodium glutamate nor the benefit of taurine has been proven.

Sources of dietary taurine include shellfish and organ meats such as liver.

Taurine, it is hoped, could eventually be used to reverse liver damage caused by alcoholism or a heavy nights drinking.Tests show that taurine can reverse, or even prevent, the build up of liver fat.

Taurine is one of the active ingredients commonly found in energy drinks such as Red Bull, and in pills which often feature caffeine and/or other stimulant ingredients. The manufacturers claim that taurine enhances the effects of caffeine, but to date there have been no studies performed to confirm this.

Taurine is essential for cats; cat food is supplemented with taurine, which is why other pet foods are not recommended for cats. In cats, taurine "helps maintain good eye health, regulate the heart beat, maintain cell membrane stability, and prevent brain cell over-activity" .

Taurine supplements may be important to counteract the effects of human aging on the natural taurine production process. As humans age, hepatic taurine production can fall or fail completely, producing low to no energy; cardiac, digestive, and mental problems; and premature death.

Read more at Wikipedia.org


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Leave your slump behind: discover the mental and physical benefits of taurine and why it can be a short-term solution to your event-filled day
From Better Nutrition, 9/1/05 by Kim Schoenhals

You've seen the commercial. A sketched man finds himself in a predicament where he needs a boost of energy. He pulls out a can, starts drinking, sprouts wings and flies away. The can is full of Red Bull, a popular energy drink that contains a number of ingredients, including 1,000 mg of taurine and 80 mg of caffeine. While caffeine is synonymous with pick-me-up, taurine remains a bit enigmatic.

Strictly speaking, taurine is a "conditionally essential" amino acid--meaning that it is only essential in certain situations, such as infant brain development. It is created during the body's metabolism of two other amino acids, cysteine and methionine. Taurine isn't utilized for protein synthesis; rather, it's stored in skeletal muscle while it waits to be used in the many other bodily functions that occur on a cellular level. These functions include helping the body to improve heart health, to detoxify and to ward off diabetes, epilepsy and cystic fibrosis. But for the most part, taurine is touted for improving endurance and energy, particularly as an ingredient in energy drinks.

While the body manufactures taurine, intense exercise may deplete it, according to a Belgian study of marathon runners printed in a 2001 issue of Amino Acids. Subsequent animal research done at the University of Florida at Gainesville, reported in a 2002 issue of the same journal, indicates that taurine supplements can increase stored levels of the amino acid, as well as improve performance.

"Taurine cannot be directly converted by the muscle into useful energy," says John Dominy, co-author of the 2002 study and currently at Cornell University in Ithaca, New York. "Taurine, however, appears to be very important in muscle ... it helps muscle maintain its normal physiological state even under conditions of stress such as prolonged exercise."

In addition to enhancing physical performance, taurine may enhance mental performance and mood, particularly when consumed in energy drinks. A preliminary study of 10 graduate students reported in a 2000 issue of Amino Acids found that Red Bull helped maintain mental reaction times, sociability and vitality into the wee hours of the night.

While supplementation appears to have beneficial effects on mental and physical performance, long-term supplementation may not be prudent. According to Dominy, recent research has shown long-term supplementation with high doses of taurine--2-3 grams per day--may actually decrease the body's ability to absorb dietary taurine, which comes from animal protein. This amount is the equivalent of 2-3 cans daily of Red Bull.

"There are transporters on cells that take up taurine from our diet," Dominy explains. Research found that when you put an animal on a high-taurine diet for a long period, those cell transporters begin to shut down. In essence, your body has a threshold for the amount of taurine it can absorb. Short-term supplementation may be beneficial, however. A study of 11 young men featured in the March 2004 issue of Amino Acids showed that one week of taurine supplementation improved endurance and stamina as well as minimized exercise's damage to the body.

While future research will likely elucidate the most effective way to use taurine supplements, the amino acid is currently enjoying a ride to fame on the coattails of the ever-expanding energy drink category--even if it can't make you sprout wings.

NOW FOODS introduces Double-strength TAURINE, 1,000-mg capsules.

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TRINITY SPRINGS announces TRINITY ENHANCED, a new line of nutrient-enriched waters including wild fruit-flavored STRENGTH with 40 mg of taurine.

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SOURCE NATURALS' TAURINE tablets are vegetarian-friendly and contain 500 mg each.

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SOBE'S NO FEAR energy drinks contain 1,000 mg of taurine and are now available in sugar-free varieties.

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TAURINE VEGICAPS, vegetarian-friendly capsules from SOLGAR, contain 500 mg of taurine.

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COPYRIGHT 2005 PRIMEDIA Intertec, a PRIMEDIA Company. All Rights Reserved.
COPYRIGHT 2005 Gale Group

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