Teriparatide is a third-line agent in osteoporosis, after calcium/vitamin D supplementation and bisphosphonates. The bisphosphonates are effective in a large majority of osteoporosis patients, and only a minority would normally require teriparatide.

Mechanism of action

Teriparatide is the portion of human parathyroid hormone (PTH),amino acid sequence 1 through 34 of the complete molecule which contains amino acid sequence 1 to 84. Endogenous PTH is the primary regulator of calcium and phosphate metabolism in bone and kidney. Daily injections of teriparatide stimulate new bone formation leading to increased bone mineral density.

Teriparatide is the first FDA approved agent for the treatment of osteoporosis that stimulates new bone formation.

FDA approval

Forsteo was approved by the FDA on 26 November 2002, for the treatment of osteoporosis in postmenopausal women who are at high risk for having a fracture. The drug is also approved to increase bone mass in men with primary or hypogonadal osteoporosis who are at high risk for fracture.

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	Teriparatide shown to strengthen bone: awaiting FDA approval for osteoporosis. (Clinical Rounds).(parathyroid hormone) : An article from: Family Practice News $5.95	Teriparatide cut spinal fracture risk at all ages. (Postmenopausal Women).(Forteo from Eli Lilly and Co.) : An article from: Family Practice News $5.95

	Parathyroid hormone may not make big league. (Costly, Demanding, Inconvenient).(use of teriparatide for osteoporosis treatment) : An article from: Family Practice News $5.95	Teriparatide may speed healing of fractures.(Rheumatology) : An article from: Internal Medicine News $5.95

	Anabolic agent may augment Osteoporosis Tx. (Teriparatide still needs FDA Aapproval). : An article from: Family Practice News $5.95	Teriparatide speeds healing of fractures.(Musculoskeleta l Disorders) : An article from: Family Practice News $5.95

	Back pain is reduced for at least 30 months after stopping teriparatide.(Gynecology) : An article from: OB GYN News $5.95	First bone-building drug wins FDA approval. (Teriparatide Reduces Fracture Risk). : An article from: Internal Medicine News $5.95

	Teriparatide sparks talk of combined therapy. (Osteoporosis Treatments).(Brief Article) : An article from: Internal Medicine News $5.95	Drug update: prevention of osteoporosis in postmenopausal women.(bisphosphonates, raloxifene, estrogen replacement, and teriparatide) : An article from: Family Practice News $5.95


Back pain is reduced for at least 30 months after stopping teriparatide VIENNA -- The risk of developing new-onset back pain is markedly decreased during and for at least 30 months after stopping teriparatide (Forteo) for ... From OB/GYN News, 11/1/05 by Bruce Jancin

Bone remodeling peaks at 1 year: benefits of teriparatide are good while they last LAS VEGAS -- Daily teriparatide injections can lower a menopausal woman's risk of fractures, thanks to marked improvement in skeletal mass and structure, ... From OB/GYN News, 9/15/04 by Norra MacReady

Teriparatide for osteoporosis Synopsis: Teriparatide (Forteo) is a synthetic human parathyroid hormone labeled for use in men and postmenopausal women with osteoporosis who are at ... From American Family Physician, 4/15/04 by Oralia V. Bazaldua

FDA approvals - Ezetimibe - Teriparatide Ezetimibe. The U.S. Food and Drug Administration (FDA) has approved ezetimibe (Zetia) for cholesterol reduction. Ezetimibe is the first in a new class ... From American Family Physician, 3/15/03 by Carrie Morantz

Teriparatide works regardless of age, fracture Hx - Linked to Fewer Vertebral Fractures Teriparatide increases vertebral density and decreases the risk of spinal fractures in postmenopausal women regardless of their age, fracture history, ... From OB/GYN News, 3/1/03 by Norra MacReady

Lilly's Teriparatide Gets Positive Opinion From European Cpmp Lilly (NYSE:LLY) has announced that the European Committee for Proprietary Medicinal Products (CPMP) has issued a positive opinion for teriparatide (rDNA origin) injection (proposed European brand From Worldwide Biotech, 2/1/03

Teriparatide studies underscore bone strengthening power - Anabolic Therapy for Osteoporosis HONOLULU -- New research unveiled at an international symposium sponsored by the National Osteoporosis Foundation emphasized the mechanistic differences ... From OB/GYN News, 5/1/02 by Betsy Bates

New anabolic agent may revamp osteoporsis Tx - Teriparatide Awaits FDA Approval HONOLULU -- The anticipated Food and Drug Administration approval of an anabolic agent, teriparatide, for the treatment of osteoporosis offers an intriguing ... From OB/GYN News, 5/1/02 by Betsy Bates

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