Temozolomide (brand name Temodar®) is an oral alkylating agent used for the treatment of refractory anaplastic astrocytoma -- a type of cancerous brain tumour. A derivative of imidazotetrazine, temozolomide is the prodrug of MTIC (3-methyl-(triazen-1-yl)imidazole-4-carboxamide). Temodar is marketed by Schering Corporation, which also markets other well-known prescription drugs such as Clarinex, Nasonex, Levitra, Cipro, Vytorin, Diprolene, Elocon and Lotrisone.

Indications

Glioblastoma multiforme: for the treatment of adult patients with newly diagnosed glioblastoma multiforme concomitantly with radiotherapy and then as manitenance treatment.
Anaplastic astrocytoma: for the treatment of adult patients with refractory anaplastic atrocytoma (ie. patients who have experienced disease progression on a drug regimen containing nitrosourea and procarbazine).
Unlabeled uses: Metastatic melanoma.

Dosage Forms

Temozolomide is available in the United States in 5mg, 20mg, 100mg, & 250mg capsules.

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	Temozolomide - A Medical Dictionary, Bibliography, and Annotated Research Guide to Internet References $34.95	Brain Ca Drug Slows Progression of Melanoma.(temozolomide)(B rief Article) : An article from: Family Practice News $5.95

	Gale Encyclopedia of Cancer : Temozolomide $3.90	Radiotherapy plus temozolomide increases glioblastoma survival.(Pulmonary Medicine) : An article from: Internal Medicine News $5.95

	Temozolomide slowed tumors in patients with glioblastoma.(Clinical Round) : An article from: Family Practice News $5.95	CTCL tumor size reduced by temozolomide Tx. (Mycosis Fungoides).(cutaneous T-cell lymphoma, treatment) : An article from: Skin & Allergy News $5.95


Thalidomide and temozolomide in the treatment of metastatic melanoma - Skin Cancer Foundation Update Melanoma is the third most common cancer to metastasize to the brain. Due to the extremely poor prognosis (median survival is often less than 6 months) ... From Journal of Drugs in Dermatology, 1/1/03 by Wen-Jen Hwu

Temozolomide vs. dacarbazine in stage IV metastatic melanoma This study is currently recruiting patients. Sponsors and Collaborators. Schering-Plough European Organization for Research and Treatment of Cancer. From Journal of Drugs in Dermatology, 11/1/05

Brain Ca Drug Slows Progression of Melanoma - temozolomide - Brief Article Temozolomide, an oral treatment indicated for brain cancer, is at least as effective for metastatic melanoma as the standard treatment, intravenous dacarbazine. In a study by Dr. Mark R. Middleto From Family Pratice News, 4/1/00 by Heather Lindsay

Temozolomide for Brain Cancer Temozolomide (Temodar) has been granted accelerated approval by the U.S. Food and Drug Administration (FDA) for the treatment of adult patients with ... From American Family Physician, 11/15/99 by Monica Preboth

Temozolomide with or without radiation therapy to the brain in treating patients with stage IV melanoma that is metastatic to the brain - Clinical Trial Sponsored by: EORTC Melanoma Cooperative Group Rationale: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Radiation therapy uses high- From Journal of Drugs in Dermatology, 6/1/03

Temozolomide Definition A chemotherapy medicine used to reduce the size of a cancerous tumor and prevent the growth of new cancer cells. In the United ... From Gale Encyclopedia of Cancer, by M.S. Monica McGee

Baseline ^sup 11^C-methionine PET reflects the natural course of grade 2 oligodendrogliomas Objectives: The aim of the present study was to assess the usefulness of positron emission tomography (PET) with the amino acid tracer ^sup 11^C-methionine ... From Neurological Research, 7/1/05 by Ribom, Dan

Research and Markets: Temozolomide Turns Heads in the Field of Brain Cancer DUBLIN, Ireland -- Research and Markets (http://www.researchandmarkets.com/reports/c20845) has announced the addition of Stakeholder Opinions: Primary ... From Business Wire, 7/15/05

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