Chemical structure of tirapazamine.
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Tirapazamine

Tirapazamine (SR-4233) is an experimental anticancer drug that is activated to a toxic radical only at very low levels of oxygen (hypoxia). Such levels are common in human solid tumors, a phenomenon known as tumor hypoxia. Thus, tirapazamine is activated to its toxic form preferentially in the hypoxic areas of solid tumors. Cells in these regions are resistant to killing by radiotherapy and most anticancer drugs. Thus the combination of tirapazamine with conventional anticancer treatments is particularly effective. As of 2006, tirapazamine is undergoing phase III testing in patients with head and neck cancer, and similar trials are being undertaken for other solid tumor types. more...

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Chemically it is an aromatic heterocycle di-N-oxide. Its full chemical name is 3-amino-1,2,4-benzotriazine-1,4 dioxide. Originally it was prepared in a programme screening for new herbicides in 1972. Its clinical use was first described by Zeman et al in 1986.

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Research and Markets: Recent Advances in Field of Oncology by Large Pharmaceutical Companies Analysed
From Business Wire, 1/24/05

DUBLIN, Ireland -- Research and Markets (http://www.researchandmarkets.com/reports/c12084) has announced the addition of Business Development and R&D Database: Oncology in Big Pharma to their offering.

This unique CD-ROM database can be used to gain knowledge about the progress made by the large pharmaceutical companies in the field of oncology. This database provides more than 10 000 records carefully identified and defined in several subcategories (see below). All records included are associated to cancer therapeutic projects related to the large pharmaceutical industry.

This exclusive database provides you with an update on the most recent advances made as well as a historical view demonstrating the competitive struggle that exists between the large pharmaceutical companies. The searchable database will also provide information about pitfalls as well as competition and business opportunities in the oncology field.

The information in the database has carefully been selected and structured to provide the most optimal and time saving platform to work from, if you are interested in general descriptions on drugs and targets as well as B2B collaborations, industry academic relationships and patent information.

Generally, the database is structured into four sections:

-- R&D activities

-- Patents

-- Collaborations

-- Company profiles

The R&D information is structured into 11 searchable segments:

-- Investigator

-- Drug name

-- Combinatory drugs

-- Developmental stage

-- Indication

-- Sub-indication

-- Therapy given

-- Drug Effects

-- Mechanisms/Targets

-- General comments

-- Source of data

The collaboration information is structured into 5 searchable segments:

-- Collaborators

-- Product

-- Developmental stage

-- Type of collaboration

-- Type of terms

Some of the drugs included in the database:

Alimta, Aromasin, Avastin, Bay 43-9006, BMS-247550, CCI-779, Edotecarin, Erbitux, Faslodex, Gleevec, Herceptin, IMC-BEC2, Iressa, Lapatinib, MelVax, PTK787, Sarasar, SU011248, Tarceva, Thalomid (+thalidomide analogs) Tirapazamine and Xeloda.

Some of the companies included in the database:

Eli Lilly, Pfizer, Genentech, Bayer AG, Bristol Myers-Squibb, Wyeth, AstraZeneca, F Hoffmann-La Roche, Merck KGaA, GlaxoSmithKline and Schering-Plough

For more information visit http://www.researchandmarkets.com/reports/c12084

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COPYRIGHT 2005 Gale Group

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