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Trimetazidine

A drug for vertigo sometimes called Vastarel. Usually 0.020g per tablet.

Trimetazidine is an anti-ischemic (anti-anginal) metabolic agent, improves myocardial glucose utilization through inhibition of fatty acid oxidation.

It improves left ventricular function in diabetic patients with coronary artery disease.

It is described as the first cytoprotective anti-ischemic agent, acts by directly counteracting all the major metabolic disorders occurring within the ischemic cell. The actions of trimetazidine include limitation of intracellular acidosis, correction of disturbances of transmembrane ion exchanges, and prevention of excessive production of free radicals.

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Bentley Pharmaceuticals Receives Approval to Market Trimetazidine in Spain; Antianginal Product Launch Planned for 2nd Quarter 2002
From Business Wire, 3/18/02

Business Editors, Health/Medical Writers

NORTH HAMPTON, N.H.--(BUSINESS WIRE)--March 18, 2002

Bentley Pharmaceuticals, Inc. (AMEX: BNT), a specialty pharmaceutical and drug delivery company with a commercial presence in Europe, announced today that its subsidiary, Laboratorios Davur, has been granted approval by the Spanish Ministry of Health to market a generic equivalent of trimetazidine in Spain.

Bentley plans to launch the product during the second quarter of 2002.

This drug belongs to a class of orally administered cardiovascular compounds used for controlling chest pain associated with angina.

James R. Murphy, chairman and CEO, said, "We are pleased to be the only generic approved for this product in Spain, as it will complement our existing cardiovascular line of products. According to the IMS, there is only one reference product on the Spanish market accounting for approximately $12 million in annual sales and growing at a rate of 12%. Trimetazidine, as well as other recent and pending approvals are expected to contribute to short-term growth of our Spanish subsidiaries."

Bentley Pharmaceuticals, Inc. is a specialty pharmaceutical company focused on advanced drug delivery technologies and pharmaceutical products. Bentley's proprietary drug technologies enhance or facilitate the absorption of pharmaceutical compounds across various membranes. Bentley also manufactures and markets a growing portfolio of generic and branded pharmaceuticals in Spain for the treatment of cardiovascular, gastrointestinal, infectious and neurological diseases through its subsidiaries Laboratorios Belmac and Laboratorios Davur.

Copies of the company's press releases and other information may be obtained through Bentley's web site at www.bentleypharm.com.

Safe Harbor Statement under the Private Securities Litigation Reform Act of 1995: The statements which are not historical facts contained in this press release are forward-looking statements that involve certain risks and uncertainties including but not limited to risks associated with identifying suitable drugs for drug delivery technologies, expanding generic and branded drug operations, development and commercialization of our products, relationships with our strategic partners, uncertainty of clinical trials, regulatory approval process, product sales concentration, unpredictability of patent protection, technological changes, the effect of economic conditions and other uncertainties detailed in Bentley's filings with the Securities and Exchange Commission.

COPYRIGHT 2002 Business Wire
COPYRIGHT 2002 Gale Group

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