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Churg-Strauss syndrome

Churg-Strauss syndrome (also known as allergic granulomatosis) is a form of vasculitis due to autoimmunity, leading to necrosis. It involves mainly the arteries, the lungs (it begins as a severe type of asthma), and nerves. Churg-Strauss syndrome is classified both as a type of polyarteritis nodosa and, more broadly, as a diffuse connective tissue disease.

Diagnosis

Diagnostic markers include eosinophil granulocytes and granulomas in affected tissue and pANCA antibodies against neutrophil granulocytes. Differentiation from Wegener's granulomatosis can be difficult.

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Montelukast-associated Churg-Strauss syndrome - Author Abstract
From Age and Ageing, 9/1/03 by Atef B. Michael

A 68-year-old asthmatic presented markedly unwell with arthralgia, mononeuritis multiplex, peripheral neuropathy, and eosinophilia. His past medical history included perennial rhinitis, and nasal polyps. Three months prior to admission his prednisolone was stopped and Montelukast was started. The diagnosis of Montelukast-associated Churg-Strauss syndrome was made. The drug was stopped and steroids started with general improvement and reduction of eosinophilia; however, the neurological deficit persisted.

COPYRIGHT 2003 Oxford University Press
COPYRIGHT 2003 Gale Group

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