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Cor pulmonale

Cor pulmonale is a medical term used to describe a failure of the right side of the heart. It is caused by prolonged high blood pressure in the right ventricle of the heart, which in turn is most often caused by pulmonary hypertension - prolonged high blood pressure in the arteries or veins of the lungs. People with heart disease, or lung diseases such as cystic fibrosis, are at greater risk. more...

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Pathophysiology

There are several mechanisms leading to pulmonary hypertension and cor pulmonale:

  • Pulmonary vasoconstriction
  • Anatomic changes in vascularisation
  • Increased blood viscosity
  • Primary pulmonary hypertension

Causes

  • Acute:
    • Massive pulmonary embolization
    • Exacerbation of chronic cor pulmonale
  • Chronic:
    • COPD
    • Loss of lung tissue following trauma or surgery

Treatment

Elimination of the cause is the most important intervention. In pulmonary embolism, thrombolysis (enzymatic dissolution of the blood clot) is advocated if there is dysfunction of the right ventricle. In COPD, long-term oxygen therapy may improve cor pulmonale.

Cor pulmonale may lead to congestive heart failure (CHF), with worsening of respiration due to pulmonary edema, swelling of the legs due to peripheral edema and painful congestive hepatomegaly. This situation requires diuretics (to decrease strain on the heart), sometimes nitrates (to improve blood flow) and occasionally inotropes (to improve heart contractility). CHF is a negative prognostic indicator in cor pulmonale.

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Cor pulmonale
From Gale Encyclopedia of Medicine, 4/6/01 by Teresa G. Norris

Definition

Cor pulmonale is an increase in bulk of the right ventricle of the heart, generally caused by chronic diseases or malfunction of the lungs. This condition can lead to heart failure.

Description

Cor pulmonale, or pulmonary heart disease, occurs in 25% of patients with chronic obstructive pulmonary disease (COPD). In fact, about 85% of patients diagnosed with cor pulmonale have COPD. Chronic bronchitis and emphysema are types of COPD. High blood pressure in the blood vessels of the lungs (pulmonary hypertension) causes the enlargement of the right ventricle. In addition to COPD, cor pulmonale may also be caused by lung diseases, such as cystic fibrosis, pulmonary embolism and, pneumoconiosis. Loss of lung tissue after lung surgery or certain chest-wall disturbances can produce cor pulmonale, as can neuromuscular diseases, such as muscular dystrophy. A large pulmonary thromboembolism (blood clot) may lead to acute cor pulmonale.

Causes & symptoms

Any respiratory disease or malfunction which affects the circulatory system of the lungs may lead to cor pulmonale. These circulatory changes cause the right ventricle to compensate for the extra work required to pump blood through the lungs. The right ventricle has thin walls and is crescent-shaped. The resulting pressure causes the right ventricle to dilate and bulge, eventually leading to its failure.

Cor pulmonale should be expected in any patient with COPD and other respiratory or neuromuscular diseases. Initial symptoms of cor pulmonale may actually reflect those of the underlying disease. These may include chronic coughing, wheezing, weakness, fatigue, and shortness of breath. Edema (abnormal buildup of fluid), weakness, and discomfort in the upper chest may be evident in cor pulmonale.

Diagnosis

An electrocardiograph (EKG) will show signs such as frequent premature contractions in the atria or ventricles. Chest x rays may show enlargement of the right descending pulmonary artery. This sign, along with an enlarged main pulmonary artery, indicates pulmonary artery hypertension in patients with COPD. Magnetic resonance imaging (MRI) is often the preferred method of diagnosis for cor pulmonale because it can clearly show and measure volume of the pulmonary arteries. Other tests used to support a diagnosis of cor pulmonale may include arterial blood gas analysis, pulmonary function tests, and hematocrit.

Treatment

Treatment of cor pulmonale is aimed at increasing a patient's exercise tolerance and improving oxygen levels of the arterial blood. Treatment is also aimed at the underlying condition that is producing cor pulmonale. Common treatments include antibiotics for respiratory infection; anticoagulants to reduce the risk of thromboembolism; and digitalis, oxygen, and phlebotomy to reduce red blood cell count. A low-salt diet and restricted fluids are often prescribed.

Alternative treatment

Co-management of the patient with cor pulmonale should be coordinated between the medical doctor and the alternative practitioner. The first step in treatment is to determine the cause of the condition and to evaluate all organ systems of the body. Dietary considerations, for example a low-salt diet and reduced fluid intake aimed at reducing the edema associated with cor pulmonale, can be supportive aspects of treatment.

Prognosis

The prognosis for cor pulmonale is poor, particularly because it occurs late in the process of serious disease.

Prevention

Cor pulmonale is best prevented by prevention of COPD and other irreversible diseases that lead to heart failure. Smoking cessation is critically important. Carefully following the recommended course of treatment for the underlying disease may help prevent cor pulmonale.

Key Terms

Ventricle
A cavity, as in the brain or heart. The right ventricle of the heart drives blood from the heart into the pulmonary artery, which supplies blood to the lungs.

Further Reading

For Your Information

    Books

  • Rothfield, Glenn S., Suzanne Levert, and Greg Rothfield. Natural Medicine for Heart Disease: The Best Alternative Methods for Prevention and Treatment: High Cholesterol, High Blood Pressure, Stroke, Chest. NY: Rodale Press, 1996.
  • Springhouse Corporation. Professional Guide to Diseases. Springhouse, PA: Springhouse Corp., 1995.

    Organizations

  • American Heart Association. 7320 Greenville Ave. Dallas, TX 75231. (214) 373-6300. http://www.amhrt.org.
  • National Heart, Lung and Blood Institute. Building 31, Room 4A21, Bethesda, MD 20892. (301) 496-4236. http://www.nhlbi.nih.gov.

Gale Encyclopedia of Medicine. Gale Research, 1999.

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