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Erythromelalgia

Erythromelalgia, also known as Mitchell's disease (after Silas Weir Mitchell) and red neuralgia, is a rare disorder in which blood vessels, usually in the extremeties and especially in the feet, are blocked and inflamed, causing a painful burning and throbbing sensation and red skin. The attacks come and go, and tend to be worse in summer. Erythromelalgia is often associated with vascular diseases such as polycythaemia vera, thrombocytosis or with heavy metal poisoning. more...

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Erythromelalgia responds to cooling, and often disappears completely on taking non-steroidal anti-inflammatory drugs, such as aspirin.

A primary (or familial) form is termed erythermalgia. This occurs in patients who are younger. The disease is very rare. It has been linked to a mutation of the SCN9A (a sodium channel), the gene of which is located on the long arm of the second chromosome (2q24). It inherits in an autosomal dominant fashion.

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Erythromelalgia: small-fiber neuropathy by any other name?(Letters to the Editor) : An article from: Pediatrics $5.95 Hysterical rapid respiration, with cases: Peculiar form of rupial skin disease in an hysterial woman $100.00
Two cases of erythromelalgia (Mitchell) The occurrence of erythromelalgia in diseases of the spinal cord: An account of ten cases
Erythromelalgia: Report of two cases, with cure. From the clinic of Dr. Otto Lerch, professor of medical diagnosis, postgraduate department, Tulane University A case of erythromelalgia,: With microscopical examination of the tissue from an amputated toe, (American journal of the medical sciences)

Erythromelalgia: vasculopathy, neuropathy, or both? A prospective study of vascular and neurophysiologic studies in erythromelalgia - Washington Whispers
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