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Betahistine hydrochloride is the generic name for the anti vertigo drug SERC. It's chemical name is 2 (2' meihylaminoethyl) pyridine dihydrochloride. It is commonly prescribed for people who have balance disorders or to alleviate the vertigo symptoms associated with Ménière's disease. more...

Benzalkonium chloride

Betahistine has a similar structure to histamine and acts as an overall histamine agonist. It is believed to work by contracting the smooth muscle surrounding the middle ear which increases the blood flow and reduces the pressure in the vestibular system.

Betahistine is available in 8mg or 16mg tablets taken 3 times daily. Doses may be adjusted to between 24-48mg a day as needed. It is contraindicated for people with peptic stomach ulcers or tumours of the adrenal gland. People with bronchial asthma should be closely monitored.


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Diagnosis and treatment of Meniere's disease - Fortnightly Review
From British Medical Journal, 1/31/98 by Shakeel R. Saeed

In 1861 Prosper Meniere described a syndrome characterised by deafness, tinnitus, and episodic vertigo. Contrary to the thinking at that time, he correctly thought that the condition was a disorder of the inner ear.[1] In 1938 the principal underlying pathology, endolymphatic hydrops, was described by Hallpike and Cairns (fig 1),[2] but the precise aetiology of Meniere's disease still remains elusive. This fact, coupled with the capricious behaviour of the disease and the clinically important response to placebo treatment, has aroused controversy about its management and has plagued the scientific evaluation of the results of the various treatments used.



Over the years, a vast literature has accumulated on Meniere's disease. I have based this article on information gained from three sources.

The first was a Medline search from 1966 to 1997, which yielded nearly 2000 references using the text word "Meniere's" and 546 citations using "endolymphatic hydrops." Combining the two sets for 1992 to 1997 gave 405 references, and combining this set with the term "surgery" yielded 58 references. I examined the abstracts of these 463 citations. Recent articles on surgery for Meniere's disease predominantly report results and various minor modifications to established surgical techniques. Articles looking at the aetiology and pathogenesis of Meniere's disease and new forms of treatment are, however, of greater interest and I examined such papers more closely.

The second source was a hand search of the main ear, nose, and throat journals in the English language in 1997 as there is a three to six month lag between the results of a Medline search and current issues of a given journal. The third source was references to textbooks and a review article written by my colleagues and me in 1994.[4]


Meniere's disease predominantly affects white people, with a prevalence in the United Kingdom of 1 per 1000 of the population, both sexes being represented equally.[5] The disorder may occur in children[6] but has a peak onset between 20 and 50 years of age. The incidence of disease affecting both ears increases to over 40% with longer follow up.[7] diagnosis and

Aetiology and pathogenesis

The precise aetiology of Meniere's disease remains obscure. Several theories explaining the development of endolymphatic hydrops have been put forward, although in reality the pathogenesis is probably multi-factorial. Some or all of the aetiological factors listed below may be acting, but their precise relation to the sequence of events leading to the clinical picture remain unknown.

Anatomical--Meniere's disease is associated with several abnormalities of the temporal bone, including reduced pneumatisation of the mastoid and hypoplasia of the vestibular aqueduct.[8] The endolymphatic sac is small and lies in an abnormal position below the labyrinth.

Genetic--A familial predisposition to Meniere's disease has been recognised for over half a century. More recently, pedigree studies by Morrison yielded a family history in 7.7% with an autosomal dominant mode of inheritance, penetrance of around 60%, and obvious genetic anticipation.[5]

Immunological--The endolymphatic sac is osmotically and immunologically active.[9] Evidence of immune complex deposition in the endolymphatic sac[10] in patients with Meniere's disease has reinforced the belief that the disease is an immune disorder.

Viral--The role of neurotropic viruses is conflicting. Calenoff et al showed specific IgE to herpes simplex virus types I and II, Epstein-Barr virus, and cytomegalovirus in the serum of patients with Meniere's disease.[11] In contrast, Welling et al did not find more neurotropic viral DNA in patients with Meniere's disease than in a control group.[12]

Vascular--The association between migraine and the symptoms of Meniere's disease was recognised by Meniere himself.[1] This association has been substantiated in several studies and suggests a common vascular pathogenesis. Certainly, migraine may antedate the Meniere's symptoms by many years and occurs in as many as one in three patients.[13]

Metabolic--Endolymph is a potassium rich hyperosmolar fluid that is positively charged with respect to perilymph. Maintenance of this ionic milieu depends on the activity of sodium potassium ATPase in the stria vascularis of the cochlear duct. The endolymphatic sac is capable of secreting osmotically active molecules such as glycoproteins and glycosaminoglycans, which is probably how the sac regulates its fluid volume.[14] In Meniere's disease distension of the endolymphatic space either alters membrane permeability or causes rupture of Reissner's membrane, leading to potassium intoxication of the hair cells and vestibular neuroepithelium, with resultant deafness and vertigo. Repeated or protracted exposure of the hair cells to potassium results in chronic loss of hair cell motility, and the initial characteristic fluctuating deafness is replaced by progressive permanent deafness.[15]

Psychological-Several reports suggest a psychological basis for Meniere's disease. An increased prevalence of obsessional traits," psychosomatic personalities, and neuroses has been noted 4 patients with Meniere's disease compared with control populations.[17]

Clinical features

To try to introduce uniformity into the treatment of Meniere's disease, the American Academy of Ophthalmology and Otolaryngology introduced guidelines in 1972, which were revised by the American Academy of Otolaryngology-Head and Neck Surgery in 1985 and 1995.[17 18] Based on control of vertigo, disability, and effects on hearing, these guidelines are now a widely accepted tool for evaluating treatment.

Clinically, three stages are generally recognised.

Stage I--In the early phase of the disease, the predominant symptom is vertigo. Ibis is characteristically rotatory or rocking and is associated with nausea or vomiting. Signs of vagal disturbance, such as pallor and sweating, may occur, but loss of consciousness is not a feature. The episode is often preceded by an aura of fullness or pressure in the ear or side of the head and usually lasts from 20 minutes to several hours. Between the attacks hearing reverts to normal and examination of the patient during this period of remission invariably shows normal results.

Stage II--As the disease advances the hearing loss becomes established but continues to fluctuate. The deafness is sensorineural and initially affects the lower pitches (fig 2(a)). The paroxysms of vertigo reach their maximum severity and then tend to become less severe. The period of remission is highly variable, often lasting for several months.


Stage III--In the last stage of the disorder the hearing loss stops fluctuating and progressively worsens, both ears tending to be affected so that the prime disability is deafness (fig 2(b) and (c)). The episodes of vertigo diminish and then disappear, although the patient may be unsteady, especially in the dark.


Differential diagnosis and investigations

Classic Meniere's disease is an excellent example of a condition that can be diagnosed on clinical grounds and simple audiometric tests. Problems arise, however, because many dizzy patients have difficulty in describing their symptoms and doctors may find it difficult to construct a logical history. Overcoming this depends on detailing the symptoms and working through the differential diagnoses to reach the correct diagnosis. The box outlines the more common disorders that may give rise to vertigo.

Two investigations serve to aid clinicians when the clinical presentation is less than precise: the glycerol dehydration test and electrocochleography. The glycerol dehydration test measures the audiometric response to an oral dose of glycerol. Improvement in scores for hearing low frequency sounds and discriminating speech is diagnostic as there is no other condition apart from endolymphatic hydrops in which this change is observed. Similarly, electrocochleography gives a highly characteristic waveform in hydrops, though this test may give negative results in the early and late stages of the disease (fig 3).



Currently, the treatment of Meniere's disease is empirical. As yet, no treatment has prospectively modified the clinical course of the condition and thereby prevented the progressive hearing loss. The reasons for this are fourfold. Firstly, the precise aetiology is unknown. Secondly, the placebo effect of drugs in this disorder is widely recognised. Thirdly, the disorder has a tendency to relapse and remit Finally, the clinical course of the condition is such that over several years the vertigo eventually disappears in about 70% of patients." Nevertheless, there are numerous conservative and surgical measures available to otolaryngologists that are aimed principally at abolishing the frightening and disabling vertigo with which patients present.

Conservative measures

Time spent giving a complete explanation of the disorder and an outline of the anticipated course of the disease is therapeutic in itself and invariably has a positive effect on the subsequent management. Clinically, three situations arise in which drug treatment may be useful.

Acute attacks-Drugs aimed at sedating the vestibulo-brain stem axis are particularly useful in aborting acute attacks. These include prochlorperazine, cinnarizine, promethazine, and diazepam. Longer term use of drugs such as prochlorperazine is inadvisable as the attendant sedation may be unacceptable, and the risk of extrapyramidal side effects from protracted use requires caution, particularly in elderly people.

Maintenance treatment--Dietary salt restriction and the use of diuretics such as frusemide, amiloride, and hydrochlorothiazide is an attempt to modify the endolymphatic hydrops itself. The basis for this is historical rather than scientific as the data from the few controlled studies that exist are conflicting and the placebo effect is clinically significant.[20 21] Vasodilators are used for prophylaxis on the basis that hydrops is due to ischaemia of the stria vascularis. The histamine analogue betahistine has been subject to some scientific scrutiny, and several controlled clinical studies have shown a significant improvement in vertigo, hearing loss, and tinnitus in the short term.[22] Currently, betahistine with or without a diuretic constitutes the favoured means of providing maintenance medical treatment Drugs such as cinnarizine, propranolol (particularly if the patient has a history of migraine), and corticosteroids are also used empirically by some clinicians if the patient's symptoms are refractory to the above measures.

Ablative treatment--The toxic effects of aminoglycosides on the sensory neuroepithelium of the inner ear have long been recognised.[23] Medical ablation of the end organ with systemic streptomycin controls vertigo and has been useful in advanced bilateral Meniere's disease when poor but aidable hearing precludes surgical intervention. Cumulative doses of streptomycin, however, carry a risk of cochlear toxicity, and the incidence of ataxia and oscillopsia becomes unacceptable. The indications for this form of treatment are therefore now limited, particularly with the current interest in intratympanic delivery of gentamicin.[24] Several series show a rate of control of vertigo of around 90%, though a cochleotoxic effect is seen in 15-25% of cases. The future for intratympanic aminoglycosides in Meniere's disease is therefore promising.

Surgical treatment

Whether as the result of medical treatment or as a consequence of the clinical course of Meniere's disease, around 70% of patients have a sustained period of remission. This implies that a quarter of patients continue to have clinically important episodes of vertigo, and surgical treatment must be considered for them. The various surgical procedures advocated in Meniere's disease continue to arouse great controversy among otolaryngologists. The decision to operate and choice of procedure are often dictated by the individual surgeon's understanding and experience of a particular technique and of the threshold for surgical intervention. Broadly speaking, surgical procedures for Meniere's disease are classified as destructive or non-destructive with respect to hearing (box).

Endolymphatic sac surgery was first described in 1927 by Portmann,[25] and no other aspect of Meniere's disease has aroused more debate or controversy. As the precise role of the sac in hydrops is still not known, the precise mechanism by which the surgery works remains elusive. Nevertheless, saccus surgery is widely performed. In a recent analysis of 100 consecutive endolymphatic mastoid shunt operations, Moffat reported complete or substantial control of vertigo in 81% of patients, with clinically important improvement in hearing in 19%, using the 1985 guidelines of the American Academy of Otolaryngology-Head and Neck Surgery.[26] Such results are consistent with findings from various centres, 17 and endolymphatic sac surgery remains the most commonly used conservative operation for Meniere's disease when hearing is still serviceable.

Vestibular nerve section--In sectioning the vestibular nerve, no attempt is made to modify the underlying pathophysiology. The objective is to dissociate the offending labyrinth from the brain stem while preserving the patient's hearing. The procedure is uniformly effective, with control of vertigo in 90-95% of patients according to the series.[17] The operation, however, is a considerable undertaking and carries the attendant risks of any neurosurgical procedure in the posterior cranial fossa (fig 4).[24]


Labyrinthectomy--Extirpation of the labyrinth is indicated in patients with symptoms who have poor or non-serviceable hearing. Violating the inner ear in this manner invariably leads to total permanent deafness. However, the opposite ear may be subclinically hydropic,[28] so doctors are naturally concerned that should the disease progress in the other ear the patient may become totally deaf. The argument that in Meniere's disease, any hearing, however poor, should be preserved is exemplified by the widespread use of the non-destructive procedures.

Cochlear implantation--Over the past decade the auditory rehabilitation of certain profoundly deaf people has been transformed by cochlear implantation. Patients with severe bilateral Meniere's disease and non-serviceable hearing find their deafness is a greater handicap than any remaining vertigo, and end stage bilateral Meniere's disease is a recognised indication for cochlear implantation.

Selection of surgical procedure

Surgeons with patients with symptoms whose disease is refractory to medical treatment have several surgical options. Broadly, three management strategies have evolved. Proponents of endolymphatic sac surgery view this as the first surgical step, reserving either revision sac surgery or a vestibular neurectomy for patients who continue to have vertigo. Those who view sac surgery as a non-specific or placebo operation and are versed in neurotological practice will consider a vestibular neurectomy as the first line surgical procedure. The third group of surgeons, who also see little merit in sac surgery but have no experience of neurotology, are faced with the option of either undertaking a labyrinthectomy or referring the patient to a neurotologist for a vestibular neurectomy. Perhaps the use of intratympanic aminoglycosides will be a viable intermediate line of management.


Over 135 years after it was first described, every facet of Meniere's disease continues to evoke controversy. The precise aetiology and pathogenesis remain elusive, the diagnosis remains inaccurate, and the behaviour of the disease remains capricious. Not surprisingly, much of the treatment is empirical and provokes much debate among otolaryngologists. Although the condition cannot currently be cured in the true sense, most patients can be managed satisfactorily and an inadequate understanding of the underlying mechanisms should not detract from the prime objective--to provide symptomatic relief for the patients who have this difficult and disabling disorder.

I thank Professor Richard Ramsden for his invaluable advice during the preparation of this paper. Figure 4 is reproduced with permission of Professor Jacques Magnan (Service d' Oto-Rhino-Laryngologie, Hopital Nord, Marseilles).

[1] Meniere P. Pathologie auriculaire: memoires sur des lesions de l'oreille interne donnant lieu a des symptoms des congestion cerebrale apoplectiforme. Gaz Med Paris 1861;16:597-601.

[2] Hallpike CS, Cairns H. Observations on the pathology of Meniere's syndrome J Laryngol Otol 1938;53:625-55.

[3] Hawke M, Jahn AF. Diseases of the ear--clinical and Pathological aspects. London: Mosby-Wolfe, 1987.

[4] Saeed SR, Birzgatis AR, Ramsden RT. Meniere's disease. Br J Hosp Med 1994;51:603-12.

[5] Morrison AW. Anticipation in Meniere's disease. J Laryngol Otol 1995;109:499-502.

[6] Bachor E, Karmody CS. Endolymphatic hydrops in children J Oto-Rhino-Laryngol Related Specialties 1995;57:129-34.

[7] Morrison AW. Meniere's disease. J R Soc Med 1981;74:183-9.

[8] Yamamoto E, Mizukami C. Development of the vestibular aqueduct in Meniere's disease. Acta Oto-Laryngol 1993;504(suppl):46-50.

[9] Derebery MJ. Allergic and immunological aspects of Meniere's disease. Otolaryngol-Head Neck Surg 1996;114:360-5.

[10] Dornhoffer JL, Warier M, Arenberg IK, Montague D. Immunoperoxidase study of the endolymphatic sac in Meniere's disease. Laryngoscope 1993;103:1027-34.

[11] Calenoff E, Zhao JC, Derlacki EL, Harrison WH, Selmeckzi K, Dutra JC, et al. Patients with Meniere's disease possess IgE reacting with herpes family viruses. Arch Otolaryngol-Head Neck Surg 1995;121:861-4.

[12] Welling DB, Daniels RI, Brainard J, Western LM, Prior TW. Detection of viral DNA in endolymphatic sac tissue from Meniere's disease patients. Am J Otol 1994;15:639-43.

[13] Parker W. Meniere's disease. Etiological considerations. Arch Otolaryngol-Head Neck Surg 1995;121:377-82.

[14] Knight LC, Saeed SR, Hradek GT, Schindler RA. Insulin receptors on the endolymphatic sac: an autoradiographic study. Laryngoscope 1995;105:635-8.

[15] Zenner HP, Reuter G, Zimmermann U, Gitter AH, Fermin C, LePage EL. Transitory endolymphatic leakage induced hearing loss and tinnitus: depolarization, biphasic shortening and loss of electromotility of outer hair cells. Eur Arch Oto-Rhino-Laryngol 1994;251:143-53.

[16] Stephens SDG. Personality tests in Meniere's disease. J Laryngol Otol 1975;89:479-82.

[17] Moffat DA, Ballagh RH. Meniere's disease. In: Booth JB, ed. Scott-Brown's otolaryngology. Vol 3. Otology. London: Butterworth, 1997:19/1-50.

[18] Pearson B, Brackmann D. Committee on Hearing and Equilibrium guidelines for reporting treatment results in Meniere's disease. Otolaryngol-Head Neck Surg 1985;93:579-81.

[19] Silverstein H, Smouha E, Jones R. Natural history versus surgery for Meniere's disease. Otolaryngol-Head Neck Surg 1989;100:6-16.

[20] Santos PM, Hall RA, Snyder JM, Hughes LF, Dobie PA. Diuretic and diet effect on Meniere's disease evaluated by the 1985 Committee on Hearing and Equilibrium guidelines. Otolaryngol-Head Neck Surg 1993;109:680-9.

[21] Ruckenstein MJ, Rutka JA, Hawke M. The treatment of Meniere's disease: Torok revisited. Laryngoscope 1991;101:211-8.

[22] Brookes GB. The pharmacological treatment of Meniere's disease. Clin Otolaryngol 1996;21:3-11.

[23] Hellstrom S, Odkvist L. Pharmacological labyrinthectomy. Otolaryngol Clin North Am 1994;27:307-15.

[24] Nedzelski JM, Schessel DA, Bryce GE, Pheiderer AG. Chemical labyrinthectomy: local application of gentamicin for the treatment of unilateral Meniere's disease. Am J Otol 1992;13:18-22.

[25] Portmann G. Vertigo: surgical treatment by opening the saccus endolymphaticus. Arch Otolaryngol 1927;83:316-9.

[26] Moffat DA. Endolymphatic sac surgery: analysis of 100 operations. Clin Otolaryngol 1994;19:261-6.

[27] Magnan J, Chays A, Cohen JM, Caces F, Locatelli P. Endoscopy of the cerebellopontine angle. Rev Laryngol Otol Rhinol 1995;116:115-8.

[28] Moffat DA, Baguley DM, Harries MI, Atlas MD, Lynch CA Bilateral electrocochleographic findings in unilateral Meniere's disease. Otolaryngol-Head Neck Surg 1992;107:370-3.

RELATED ARTICLE: Surgical options in Meniere's disease

Not destructive to hearing

Endolymphatic sac surgery

Vestibular nerve section


Ultrasound treatment

Cryosurgical treatment

Insertion of tympanostomy tubes

Cervical sympathectomy

Destructive to hearing



Vestibulocochlear neurectomy

Translabyrinthine vestibular neurectomy

RELATED ARTICLE: Summary points

The aetiology of Meniere's disease is multifactorial but the relation between these factors and the development of the disease remains unknown

Distension of the endolymphatic compartment of the inner ear may be due to otological or systemic disorders and is the constant pathological finding

This condition can be diagnosed on clinical grounds and simple audiometry. Secondary endolymphatic hydrops and space occupying lesions of the cerebellopontine angle need to be excluded

The relapsing-remitting nature of the disorder, response to placebo, and undetermined aetiology have plagued scientific attempts to evaluate treatments

Around three quarters of patients respond to medical treatment or enter a state of prolonged remission. For the rest, surgery aims to control the disabling vertigo

Bilateral Meniere's disease remains a therapeutic challenge

RELATED ARTICLE: Differential diagnosis of vertigo

Rotatory vertigo

Benign paroxysmal positional vertigo Vertebrobasilar insufficiency Meniere's disease Secondary or delayed endolymphatic hydrops Vestibular neuronitis Head injury Labyrinthine fistula Infective labyrinthitis Otological surgery Otosclerosis Cerebellopontine turnouts or vascular lesions Disseminated sclerosis


Side effects of drugs Lesions in central nervous system Active chronic suppurative otitis media Head injury Perilymph fistula Hyperventilation Functional (non-organic)

University Department of Otolaryngology-Head and Neck Surgery, Manchester Royal Infirmary, Manchester M13 9WL

Shakeel R Saeed, senior registrar in otolaryngology

BMJ 1998;316:368-72

COPYRIGHT 1998 British Medical Association
COPYRIGHT 2000 Gale Group

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