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Betahistine

Betahistine hydrochloride is the generic name for the anti vertigo drug SERC. It's chemical name is 2 (2' meihylaminoethyl) pyridine dihydrochloride. It is commonly prescribed for people who have balance disorders or to alleviate the vertigo symptoms associated with Ménière's disease. more...

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Betahistine has a similar structure to histamine and acts as an overall histamine agonist. It is believed to work by contracting the smooth muscle surrounding the middle ear which increases the blood flow and reduces the pressure in the vestibular system.

Betahistine is available in 8mg or 16mg tablets taken 3 times daily. Doses may be adjusted to between 24-48mg a day as needed. It is contraindicated for people with peptic stomach ulcers or tumours of the adrenal gland. People with bronchial asthma should be closely monitored.

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First Ever Homeopathic Study Based On Modern Scientific Methodology Published in AMA Journal
From Business Wire, 8/13/98

ALBUQUERQUE, N.M.--(BW HealthWire)--August 13, 1998--

VERTIGOHEEL(R) Shown to be Safe and Effective in the Treatment of Vertigo

A study published in the August issue of the American Medical Association journal Archives of Otolaryngology - Head and Neck Surgery shows that VERTIGOHEEL(R), a prescription homeopathic medication, is as effective and safe as betahistine, a histamine analogue considered standard therapy in Europe for the management of vertigo symptoms.

The publication of this study in an AMA journal reflects the growing interest in homeopathic medicine. In fact, in the July 15, 1998 issue of the Journal of the American Medical Association (JAMA), a survey of readers identified "alternative medicine" such as homeopathy, as one of the top ten topics of which more information should be published.

Vestibular or balance disorders such as vertigo, dizziness, and motion sickness affect approximately two million people in the U.S. Despite the severity of vertigo, American physicians lack a conventional medication proven to be an effective treatment for the disease. This study represents the first equivalence trial comparing a homeopathic treatment for vertigo to standard drug therapy.

"This is the first time that the AMA has published a study of a homeopathic drug - a study that was designed according to modern scientific methodology," said Dana Ullman, MPH, president of the Foundation for Homeopathic Education and Research and author of numerous books on homeopathy. "Other respected, peer-reviewed medical publications such as The Lancet, Pediatrics and British Medical Journal are now joined by the AMA's Archives of Otolaryngology in their scientific review of homeopathic studies."

The year-long, double-blind, randomized, controlled clinical trial compared the efficacy and safety of VERTIGOHEEL(R) with betahistine. The study included 119 male and female patients with acute or chronic vertigo symptoms of various origins. The clinical trial was conducted from 1995 to 1996 at 15 medical clinics throughout Germany. In accordance with good clinical practices, patients were assigned to one of two treatment groups: the VERTIGOHEEL(R) group or the betahistine group. Patients in both groups were given 15 drops three times per day of the active drug (VERTIGOHEEL(R) or betahistine) for 42 consecutive days.

Study Results

The primary efficacy variables for the study were the frequency, duration, and intensity of vertigo attacks. After six weeks, vertigo-specific complaints were significantly reduced in both treatment groups. VERTIGOHEEL(R) and betahistine were therapeutically equivalent in reducing the duration and intensity of vertigo attacks. Although not clinically significant, VERTIGOHEEL(R) was marginally superior to betahistine in reducing the frequency of vertigo attacks.

The study's secondary efficacy variables involved quality of life measurements, including physical health and mental activity, from the patients' point of view. These were assessed using the standardized MOS-SF36 validated quality of life questionnaire as well as a four-part vertigo-specific questionnaire. The patients' and investigators' global assessment of efficacy also comprised the study's secondary efficacy variables. There was an increase in the patients' quality of life and a significant decrease in vertigo-specific symptoms in both treatment groups. According to investigators, more than 70 percent of patients in both of the VERTIGOHEEL(R) and betahistine groups reported a significant improvement in quality of life. In addition, for more than 90 percent of study patients in both treatment groups, the tolerability of both drugs was rated as "good" or "excellent."

Clinical laboratory data and vital signs for each patient remained essentially unchanged throughout the course of the study, indicating a favorable safety profile for both VERTIGOHEEL(R) and betahistine.

"These results establish VERTIGOHEEL(R) as a safe and effective treatment for vertigo," said study investigator Michael Weiser, PhD, Director of Clinical Research, Heel, GmbH. "VERTIGOHEEL(R) was shown to be as effective as betahistine, a standard anti-vertigo drug, in significantly reducing the frequency and severity of vertigo attacks and was also very well-tolerated. Because of the lack of effective conventional treatments, VERTIGOHEEL(R) fills a serious void for treating millions of Americans suffering from vertigo and other types of dizziness."

"We are excited about the publication of this head-to-head clinical comparison in an American Medical Association (AMA) journal," said Perry Pedersen, Vice President, General Manager, Heel Inc., the U.S. manufacturer and exclusive distributor of VERTIGOHEEL(R). "Not only does it prove that VERTIGOHEEL(R) is an effective and safe drug for treating vertigo, but it also demonstrates why homeopathic drugs are gaining acceptance

COPYRIGHT 1998 Business Wire
COPYRIGHT 2004 Gale Group

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