Valdecoxib chemical structure
Find information on thousands of medical conditions and prescription drugs.

Bextra

Valdecoxib is a prescription drug used in the treatment of osteoarthritis, rheumatoid arthritis, and painful menstruation and menstrual symptoms. It is classified as a nonsteroidal anti-inflammatory drug, or NSAID, and should not be taken by anyone allergic to these types of medications. more...

Home
Diseases
Medicines
A
B
Baciim
Bacitracin
Baclofen
Bactrim
Bactroban
Barbexaclone
Barbital
Baros
Basiliximab
Baycol
Beclamide
Beclometasone
Beclovent
Beconase
Beldin
Benadryl
Benazepril
Bendroflumethiazide
Benserazide
Bentiromide
Benylin
Benzaclin
Benzalkonium chloride
Benzocaine
Benzonatate
Betacarotene
Betadine
Betahistine
Betamethasone
Betaxolol
Bextra
Biaxin
Bibrocathol
Bicalutamide
Bicillin
Biclotymol
Biotin
Bisoprolol
Bleomycin
Blocadren
Boldenone
Boniva
Bontril
Bosentan
Bravelle
Brethaire
Brevibloc
Brevicon
Bricanyl
Bromazepam
Bromelain
Bromhexine
Bromocriptine
Brompheniramine
Bronkodyl
Bronopol
BSS
Bucet
Budesonide
Bumetanide
Bupivacaine
Buprenex
Buprenorphine
Buserelin
Buspar
Buspirone
Busulfan
Butalbital
C
D
E
F
G
H
I
J
K
L
M
N
O
P
Q
R
S
T
U
V
W
X
Y
Z

Valdecoxib was manufactured and marketed under the brand name Bextra® by G. D. Searle & Company. It was available by prescription in tablet form until 2005, when it was removed from the market due to concerns about possible increased risk of heart attack and stroke.

Uses

Since its registration, Bextra was prescribed for pain associated with arthritis, menstrual discomfort, and other ailments.

Side-effects and withdrawal

On April 7, 2005, Pfizer withdrew Bextra from the US market on recommendation by the FDA, citing an increased risk of heart attack and stroke and also the risk of a serious, sometimes fatal, skin reaction. This was a result of recent attention to prescription NSAIDs, such as Merck's Vioxx. Other reported side-effects were angina and Stevens-Johnson syndrome.

Pfizer first acknowledged cardiovascular risks associated with Bextra in October of 2004. The American Heart Association soon after was presented with a report indicating patients using Bextra while recovering from heart surgery were 2.19 times more likely to suffer a stroke or heart attack than those taking placebos.

Personal injury

With the removal of the drug from the market, there is expected to be a surge in personal injury claims, many in the form of class action, to seek compensation.

Read more at Wikipedia.org


[List your site here Free!]


The FDA has issued a warning for users taking Bextra® , a COX-2 specific inhibitor - valdecoxib tablets - Clinical News in Brief
From Drug Cost Management Report, 12/1/02

* The FDA has issued a warning for users taking Bextra[R] (valdecoxib tablets), a COX-2 specific inhibitor for treating the signs and symptoms of osteoarthritis, adult rheumatoid arthritis and primary dysmenorrhea. Just weeks after researchers lauded the drug's upper gastrointestinal and cardiovascular safety in October, FDA publicized reports of serious reactions to the painkiller. Since March, FDA has received 20 reports of reactions, including rashes indicative of Stevens-Johnson syndrome, toxic epidermal necrolysis and exfoliative dermatitis, as well as other allergic reactions. Approximately 800,000 to 1 million people had recently begun taking Bextra when the reactions were reported, says FDA. The skin conditions are rare, but can be life-threatening, and drug manufacturer Pharmacia Corp. has written thousands of doctors alerting them to the danger since the FDA warning.

COPYRIGHT 2002 Atlantic Information Services, Inc.
COPYRIGHT 2003 Gale Group

Return to Bextra
Home Contact Resources Exchange Links ebay