Bisoprolol can be used to treat cardiovascular diseases such as hypertension, coronary heart disease, arrhythmias, and treatment of myocardial infarction after the acute event. Patients with compensated congestive heart failure may be treated with Bisoprolol as a comedication (usually together with an ACE inhibitor, a diuretic and a digitalis-glycosid, if indicated). In patients with congestive heart failure, it reduces the need for and the consumption of oxygen of the heart muscle. It is very important to start with low doses, as bisoprolol reduces also the muscular power of the heart, which is an undesired effect in congestive heart failure.

The drug is also used to treat other conditions, including dysautonomia, anxiety and hyperthyroidism (overfunction of the thyroid gland).

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Mylan Announces Final Approval for Bisoprolol Fumarate Tablets, USP
From PR Newswire, 12/19/05

PITTSBURGH, Dec. 19 /PRNewswire-FirstCall/ -- Mylan Laboratories Inc. today announced that Mylan Pharmaceuticals Inc. has received final approval from the U.S. Food and Drug Administration (FDA) for its Abbreviated New Drug Application (ANDA) for Bisoprolol Fumarate Tablets USP, 5mg and 10mg. Bisoprolol Fumarate Tablets, which are the AB-rated generic version of Duramed Pharmaceuticals' Zebeta(R) Tablets, 5mg & 10 mg, had U.S. sales of approximately $27 million, for the 12-month period ended June 30, 2005, according to IMS Health.

Mylan Laboratories Inc. is a leading pharmaceutical company with three principal subsidiaries, Mylan Pharmaceuticals Inc., Mylan Technologies Inc. and UDL Laboratories, Inc., that develop, license, manufacture, market and distribute an extensive line of generic and proprietary products.

For more information about Mylan, visit http://www.mylan.com/.

CONTACT: Patrick Fitzgerald, or Kris King of Mylan Laboratories Inc., +1-724-514-1800

Web site: http://www.mylan.com/

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