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Bosentan

Bosentan is an endothelin receptor antagonist important in the treatment of pulmonary artery hypertension.

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Long term experience with bosentan in patients with pulmonary arterial hypertension associated with advanced idiopathic pulmonary fibrosis and interstitial
From CHEST, 10/1/05 by Ganesh Raghu

PURPOSE: Bosentan is an experimental antifibrotic agent and approved for the management of PAH. Patients with ILD often manifest PAH as pulmonary fibrosis (PF) advances to endstage. To determine the safety, tolerance and clinical status of consecutive patients who were dyspneic with exertion and received bosentan (>3 months) for PAH secondary to advanced PF, available clinical data was retrospectively analyzed.

METHODS: Echocardiogram confirmed the presence of PAH in all patients. Diagnosis of ILD and underlying specific diagnosis was in accordance with accepted clinical criteria. Exclusions: coexisting COPD (FEV1/FVC <0.7 and RV >120%), concurrent treatment indicated for PAH, other than bosentan, and LVEF <35%. Pulmonary function tests (PFTs) and 6MWT were obtained at baseline and at 3-6-month intervals.

RESULTS: During 1/2000-3/2005, 50 adult, consecutive endstage ILD patients (25 IPF, 12 PF associated with collagen vascular disease, 4 idiopathic nonspecific interstitial pneumonia, 5 sarcoid, 4 other ILD) received bosentan. Mean treatment duration and follow up was 11.1 [+ or -] 8.0, range 3-30 months. Concomitant medications included prednisone in 45, azathioprine in 18, N-acetylcysteine in 31, interferon-gamma in 3 and 24h 02 therapy in 39 patients. Compared to pretreatment values, hemodynamics and PFTs did not deteriorate during bosentan treatment (baseline [right arrow] 6 mo [right arrow] 12 mo): estimated mean PA systolic pressure [+ or -] SEM: 54 [+ or -] 2.7 [right arrow] 56 [+ or -] 2.9 [right arrow] 53 [+ or -] 6.4 mmHg; FVC predicted: 55.0 [+ or -] 2.6 [right arrow] 56.5 [+ or -] 2.8 [right arrow] 58.5 [+ or -] 4.1%; DLCO predicted: 33.0 [+ or -] 1.6 [right arrow] 35.1 [+ or -] 2.1 [right arrow] 36.1 [+ or -] 3.0 %; 6MWT (n=25): A resting and lowest SpO2:8.5 [+ or -] 0.8 [right arrow] 9.7 [+ or -] 1.5 [right arrow] 7.0 [+ or -] 1.0; 6MWT distance: 670 [+ or -] 79 [right arrow] 828 [+ or -] 105 [right arrow] 525 [+ or -] 249 feet. At last follow-up, 38 patients are alive and stable and 2 lost to follow-up. Abnormal liver function tests > 3x ULN occurred in 1, mild anemia in 4, and leg edema in 8 patients.

CONCLUSION: Bosentan was well tolerated in patients with advanced PF in endstage ILD. During the study period, the vast majority of patients stabilized in PFTs and SpO2 during 6MWT.

CLINICAL IMPLICATIONS: Bosentan may have a useful clinical role in advanced stages of PF associated with ILD.

DISCLOSURE: Ganesh Raghu, Grant monies (from industry related sources) GR is a consultant and advisor for research studies for IPF and scleroderma lung for Actelion,and has received research grants from Actelion. The study was sponsored by Actelion Pharmaceuticals, Allschwil, Switzerland.

Ganesh Raghu MD * Jennifer Hayes RN Carolyn Spada RN Jeffrey Moniz RN Steve Yang MBBS Division of Pulmonary and Critical Care Medicine, Seattle, WA

COPYRIGHT 2005 American College of Chest Physicians
COPYRIGHT 2005 Gale Group

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