Bromocriptine chemical structure
Find information on thousands of medical conditions and prescription drugs.

Bromocriptine

Bromocriptine, an ergoline derivative, is a dopamine agonist that is used in the treatment of pituitary tumors and Parkinson's disease. more...

Home
Diseases
Medicines
A
B
Baciim
Bacitracin
Baclofen
Bactrim
Bactroban
Barbexaclone
Barbital
Baros
Basiliximab
Baycol
Beclamide
Beclometasone
Beclovent
Beconase
Beldin
Benadryl
Benazepril
Bendroflumethiazide
Benserazide
Bentiromide
Benylin
Benzaclin
Benzalkonium chloride
Benzocaine
Benzonatate
Betacarotene
Betadine
Betahistine
Betamethasone
Betaxolol
Bextra
Biaxin
Bibrocathol
Bicalutamide
Bicillin
Biclotymol
Biotin
Bisoprolol
Bleomycin
Blocadren
Boldenone
Boniva
Bontril
Bosentan
Bravelle
Brethaire
Brevibloc
Brevicon
Bricanyl
Bromazepam
Bromelain
Bromhexine
Bromocriptine
Brompheniramine
Bronkodyl
Bronopol
BSS
Bucet
Budesonide
Bumetanide
Bupivacaine
Buprenex
Buprenorphine
Buserelin
Buspar
Buspirone
Busulfan
Butalbital
C
D
E
F
G
H
I
J
K
L
M
N
O
P
Q
R
S
T
U
V
W
X
Y
Z

Amenorrhea, female infertility, galactorrhea, hypogonadism, and acromegaly may all be caused by pituitary problems, and therefore, these problems may be treated by this drug. It is also used following stillbirth to suppress the mother's production of breast milk as that may add to her distress.

Because of its effects as a dopamine agonist, bromocriptine has potential use in treating addiction to cocaine, a drug that exhibits its own effects by blocking dopamine reuptake. Although it has negligible subjective effects when administered alone, studies show it has the potential to significantly ease the cocaine withdrawal syndrome. See references below.


Read more at Wikipedia.org


[List your site here Free!]


Eosinophilic pleural effusion due to artemisnin: a case report
From CHEST, 10/1/05 by Mayank Vats

INTRODUCTION: Drug induced eosinophilic pleural effusion (EPE) is well documented in literature. EPE is not a disease rather an interesting laboratory finding, defined as >10% eosinophils in pleural fluid, exclusive of erythrocytes. Pleural fluid eosinophilia may be associated with blood eosinophilia e.g. Loeffler syndrome, Churg Strauss syndrome etc. Conversly EPE can also occur without blood eosinophilia e.g. Pulmonary Infarction, Pneumonia or Trauma. We report a case of bilateral EPE secondary to Artemisnin with no peripheral eosinophilia.

CASE PRESENTATION: AM 46-year-old female presented to OPD because of bilateral dull aching chest pain, which increased, on taking deep breath. Five days before the presenting illness she also had high grade fever with chills for which she received injection Artemisinin on the suspicion of malaria in another tertiary health care center. The patient demonstrated no symptom, sign or laboratory data of any infectious process, Chest X-Ray PA revealed bilateral pleural effusion more on right side & no parenchymal infiltrates. Patient underwent right thoracentesis, revealing protein-4.2 g/dl, 60%-lymphocyte, 26%-eosinophils, 10%-mesothelial cells & 4%-polymorphs. Next day, left thoracentesis revealed protein-4.4 g/dl, 56%-lymphocytes, 32%-eosinophils, 8%-mesothelial cell & 4%-polymorphs. Pleural biopsy showed mixed lymphocytic & eosinophilic infiltrates within pleura. The bacterial, fungal & mycobacterial smear & culture of fluid & biopsy specimen were negative after 6 weeks. Her serology was negative for Anti-Nuclear Antibody, LE cells, & Rheumatoid factor. There was no history of contact of pulmonary tuberculosis & Montoux test was negative. A detailed history of illness (including absence of any significant past medical history), drug intake & complete evaluation strongly pointed out towards a possible drug (Artemisnin) induced pleural effusion, hence after informed consent & with permission of ethical society of institution, injection Artemisnin 40mg IM x 5 days was given, as challenge dose & on 7th day patient again developed bilateral chest pain & Chest X-Ray revealed bilateral minimal pleural effusion. Patient was started on prednisolone 60 mg/day for 7 Days & pleura] effusion disappeared completely, hence confirming the diagnosis.

DISCUSSIONS: Air & Blood are the most common cause of EPE. Other causes of EPE1 are Bronchial or Pleural malignancy, hypersensitivity reactions, pulmonary infarction & infection with viruses, fungus (2) (Coccidiodomycosis, Histoplasmosis) & parasites (Echinococcus, Amoebiasis, Ascariaris, Schistosomiasis, Ankylostomiasis etc.). Drug reactions like Dantrolene, Bromocriptine, Nitrofurantoin. Procarbazine, Ergot, Methotrexate has been implicated in EPE. Allergic disease like Asthma, Tropical Pulmonary Eosonipbilia, Churg-Strauss syndrome may also lead to Eosinophilic Pleural Effusion. (3) In this case the absence of other causes for the EPE & its complete resolution after withdrawal of Artemisnin, reappearance on challenging with low dose supports a causative relationship of this drug with the development of EPE. This is probably the first case report of EPE secondary to Artemisnin.

CONCLUSION: Artemisnin must be included in the list of drugs causing EPE, however the exact mechanism is not known, but, if the drug is considered as a cause of EPE, the drug should be immediately discontinued. Clinical Implications: a high degree of suspicion should always be kept in mind to prove the drug as an etiologic agent in undiagnosed EPE, and a challenge test with all due precautions should always be done to prove or disprove this etiology.

REFERENCES:

(1) Campbell GD, Webb WR: Eosinophilic Pleural Effusion, Amer. Rev. Resp. Dis. 1964, 90, 194.

(2) Curran WS, Williams AW: Eosinophilic Pleural Effusion, Arch. Inern. Med. (Chiacgo) 1963, 111, 809.

(3) Erzurum SE, Underwood GA, Hamilos DL, Waldron JA: Pleural eff

DISCLOSURE: Mayank Vats, None.

Mayank Vats MD * Rakesh C. Gupta MD Deepa V. Khandelwal MBBS Manohar L. Gupta MD Neeraj Gupta MD Mukesh Tailor MBBS J.L.N. Medical College, Ajmer, Rajasthan, India

COPYRIGHT 2005 American College of Chest Physicians
COPYRIGHT 2005 Gale Group

Return to Bromocriptine
Home Contact Resources Exchange Links ebay