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Dapoxetine

Dapoxetine is the International Nonproprietary Name of a drug currently being considered for approval by the FDA for the treatment of premature ejaculation in men, which would make it the first drug approved for such treatment. It is currently in Phase III of the approval process. This would make it join the ranks of sildenafil (Viagra®), tadalafil (Cialis®), and vardenafil (Levitra®), the erectile dysfunction drugs, as a drug intended to improve male sexual health. more...

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Dapoxetine, submitted to the FDA in the form of dapoxetine hydrochloride, was developed by ALZA Corporation and its parent company, Johnson & Johnson.javascript:insertTags('','','Insert formula here'); Mathematical formula (LaTeX)

Like other drugs in this category, it is controversial for turning something that is traditionally considered psychological into a physiological problem that can be treated, to the benefit of the pharmaceutical industry (but also to the people with the dysfunction).

In October of 2005, the Food and Drug Administration issued a nonapprovable letter for Dapoxetine.

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Zacks.com Expert Watch Highlights the Following Stocks: Smith Int'l, Genesis Microchip, and Johnson & Johnson
From Business Wire, 1/14/05

CHICAGO -- Zacks Experts announce commentary and recommendations on three stocks: Smith International (NYSE:SII), Genesis Microchip (NASDAQ:GNSS) and Johnson & Johnson (NYSE:JNJ). Employing various timing and investment strategies, Zacks Experts Watch gives valuable insight to individual investors, especially in turbulent markets. For the full commentary, visit; http://at.zacks.com/?id=101

Here are the highlights from the Experts Watch column:

After a very potent Santa Claus rally, and a difficult start to the New Year, investors have been left a bit flummoxed. The extreme readings of positive sentiment throughout the market at the end December saw the market drift higher for little or no reason. However, after it became clear a Santa Claus rally would come to fruition, there was little the bears could do to fight it off. Yet, the bears launched a correction immediately upon the inception of 2005, which shook out a bunch of the complacent investors. The question now is, "What's Next?" The experts scrutinize sentiment and fundamentals to answer this question and highlight their favorite stocks for this New Year.

Dr. Melvin Pasternak, editor of the StreetAuthority Swing Trader, notes that bullish sentiment has declined dramatically over the last several weeks. The 10-day moving average of the CBOE Put/Call Ratio has risen to .82, a neutral level, after hovering near .55 for most of December. The low ratio of puts, contracts to sell a stock at a given price level due to expectations it will fall, relative to calls indicates that the options traders were broadly expecting stocks to rise. Hence, the increase in the ratio is evidence that there is less expectation for stocks to rise.

Right now, Pasternak recommends that Swing Traders take a position in oil-field services stock Smith International (NYSE:SII). Smith hit a peak near $62.00 in late November, before bottoming at $51.60 earlier this month. The stock is now rebounding smartly. Dr. Pasternak thinks SII can test its old high.

Pasternak opened a position in Genesis Microchip (NASDAQ:GNSS) earlier in the week in his model portfolio. Genesis manufactures integrated circuits which enable the viewing of graphic images on flat panel displays. The stock dropped from a high of $22 in January 2004 to a low just beneath $10 in early July. It then recovered and made a double top formation in November and December. The stock again appears to be heading south. The shares broke the Intermediate uptrend line in early December and have been trending lower since that time. Genesis is demonstrating declining relative strength to the S&P 500.

Richard Moroney, editor of Dow Theory Forecasts punctuates the astonishment at the levels of bullishness, referencing the Investors Intelligence survey that marked level of 63% of investment advisers as bullish. He cites a number of trends the bulls can find as evidence for their investment thesis, including the Presidential and the 5-year cycles. Further, monetary policy provides support in the form of dividends.

Moroney looks for rising earnings and sales trends for his stocks, and sees the aggregate trends as moving in the market's favor. One such stock is Johnson & Johnson (NYSE:JNJ), which is the fourth-largest U.S. drugmaker and the largest maker of medical devices. Late last month, J&J filed a new-drug application for Dapoxetine, expected to be the first oral prescription therapy for premature ejaculation. FDA approval of the treatment could come in late 2005. For 2004, per-share earnings should climb about 16% to $3.07. That estimate has climbed $0.04 over the last three months. For 2005, the consensus estimate is $3.35, up $0.05 since October.

Read the full report with insight from the experts at Zacks.com: http://at.zacks.com/?id=102

About Zacks Experts Watch

Successful investing requires professional advice from knowledgeable experts who can help investors achieve their financial goals in good markets improve their portfolios, especially in bad markets. That is why Zacks Investment Research has assembled the best investment experts in the business to offer their powerful advice on all the major investment topics.

Additional recommendations from Zacks Experts are highlighted in free investment newsletter, Profit from the Pros.

Each issue highlights several experts with a track record of beating the street in this e-mail newsletter. Register for a free subscription to "Profit from the Pros" at: http://at.zacks.com/?id=103

About Zacks

Zacks.com is a property of Zacks Investment Research, Inc., which was formed in 1978 to compile, analyze, and distribute investment research to both institutional and individual investors. The guiding principle behind Zacks work is the belief that investment experts, such as brokerage analysts and investment newsletter writers, have superior knowledge about how to invest successfully. The goal is to unlock these pros' profitable insights for individual investors hard-pressed to find this valuable information in one source. A free subscription to "Profit from the Pros" weekly e-mail newsletter provides the best way to use these experts' insights for more profitable investing. Register for a free subscription to the Profit from the Pros newsletter at http://at.zacks.com/?id=104

Zacks Investment Research is under common control with affiliated entities (including a broker-dealer and an investment adviser), which may engage in transactions involving the foregoing securities for the clients of such affiliates.

Disclaimer: Past performance does not guarantee future results. Investors should always research companies and securities before making any investments. Nothing herein should be construed as an offer or solicitation to buy or sell any security.

COPYRIGHT 2005 Business Wire
COPYRIGHT 2005 Gale Group

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