It inhibits the enzyme adenosine deaminase which normally breaks down adenosine. This inhibition leads to increased levels of adenosine. Adenosine activates the enzyme adenylate cyclase which leads to increased cyclic AMP (cAMP) synthesis.
Dipyridamole also inhibits the enzyme phosphodiesterase which normally breaks down cAMP.

Both of these mechanisms lead to increased levels of cAMP within platelets. cAMP impairs platelet aggregation.

Modified release dipyridamole is used in conjunction with aspirin (Aggrenox®) in the secondary prevention of stroke and transient ischemic attack.

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Use of dipyridamole in patients with recent stroke or TIA TO THE EDITOR: Dr. Solenski's review (1) of treatment options for transient ischemic attack (TIA) discusses the additive benefits of combination therapy ... From American Family Physician, 8/1/05 by Richard A. Bernstein

Sensitivity, specificity, positive predictive value, and negative predictive value of the dipyridamole sestamibi stress test comparing arterial to vein Study objectives: To determine the sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of the dipyridamole ... From CHEST, 10/1/04 by Albert J. DeLuca

Dipyridamole stress echocardiography vs dipyridamole sestamibi scintigraphy for diagnosing coronary artery disease in left bundle-branch block - clinical Study objectives: To evaluate dipyridamole stress echocardiography (DSE) for predicting coronary artery diseases (CADs) in patients with complete left ... From CHEST, 11/1/01 by Carlo Vigna

Aspirin And Dipyridamole For The Secondary Prevention Of Stroke Wahlgren NG. Critical analysis of the combination of dipyridamole plus acetylsalicylic acid versus acetylsalicylic acid alone in the secondary prevention ... From Journal of Family Practice, 2/1/99 by Rafal Zielinski

Oral vs intravenous dipyridamole echocardiography for detecting coronary artery disease The usefulness of the intravenous dipyridamole-echocardiography test (12-lead and two-dimensional [2-D] echo monitoring during dipyridamole infusion) ... From CHEST, 10/1/92 by Fabio Lattanzi

Sinus arrest associated with dipyridamole infusion We describe a case of prolonged sinus arrest resolved by external cardiac massage following intravenous infusion of dipyridamole, during a thallium myocardial perfusion test. The arrhythmia, presu From CHEST, 2/1/94 by Renato Lo Mauro

A longitudinal evaluation of dipyridamole drug use in an ambulatory elderly population Study objective: To determine the pattern of dipyridamole use over the past 14 years. Design: A longitudinal health screening program of ambulatory elderly ... From CHEST, 4/1/95 by Ronald B. Stewart

Severe bronchospasm followed by respiratory arrest during thallium-dipyridamole imaging Jean Lette M.D., F.C.C.P.; Michel Cerino M.D.; Michel Laverdiere M.D.; Jacques Tremblay M.D.; and Julie Prenovault M.D. We describe the occurrence ... From CHEST, 6/1/89 by Jean Lette

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