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Desipramine

Desipramine is a tricyclic antidepressant (TCA) that inhibits the reuptake of norepinephrine. It is sold under the brand names Norpramin® and Pertofrane®. It is used to treat depression, but not considered a first line treatment since the introduction of SSRI antidepressants. Desipramine is an active metabolite of imipramine. more...

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Along with other tricyclics, desipramine has found use in treating neuropathic pain. The mechanism of action seems to involve the activation, through norepinephrine reuptake inhibition, of descending pathways in the spinal cord that block pain signals from ascending to the brain. Desipramine is one of the most potent and selective medications in this respect.

Some evidence suggests that desipramine may help with ADD, and along with Wellbutrin, the only serotonergic drug that is documented for this condition.

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	Desipramine: A Medical Dictionary, Bibliography, And Annotated Research Guide To Internet References $39.36	A comparison between a serotonin and a noradrenaline uptake inhibitor in endogenous depression: Clinical and biochemical findings (Bulletin / Lincoln College)

	On the kinetics of antidepressants of imipramine-type	Desipramine $0.87


Comorbid major depressive disorder as a prognostic factor in cocaine-abusing buprenorphine-maintained patients treated with desipramine and contingency Depression is common among patients who abuse both opiates and cocaine, and its treatment has had mixed success. This study compares buprenorphine-maintained ... From American Journal of Drug and Alcohol Abuse, 8/1/03 by Gerardo Gonzales

Evidence for altered desipramine disposition in methadone-maintained patients treated for cocaine abuse Desipramine, a drug used to treat depression, has recently been reported as useful in treating cocaine addiction. Many individuals are addicted to both ... From American Journal of Drug and Alcohol Abuse, 9/1/90 by Thomas R. Kosten

Use of desipramine for treatment of adult ADHD - attention deficit hyperactivity disorder - Tips from Other Journals Evidence suggests that attention deficit hyperactivity disorder (ADHD) persists in 10 to 60 percent of young adults who had ADHD as children. A substantial ... From American Family Physician, 1/1/97 by Barbara Apgar

Two lots of desipramine recalled Pharmaceutical Basics Inc. of Denver recalled two lots of its antidepressant desipramine in late March because of a label mix-up. People taking the finn's desipramine were advised to examine their From FDA Consumer, 6/1/90

Psychotherapy's road to cocaine control - short-term psychotherapy more effective than desipramine in reducing cocaine use among cocaine abusers - Brief Short-term psychotherapy that offers cocaine abusers practical strategies for maintaining abstinence sparks a marked drop in their overall cocaine use ... From Science News, 12/24/94 by Bruce Bower

Antidepressants and antiepileptic drugs for chronic non-cancer pain The development of newer classes of antidepressants and second-generation antiepileptic drugs has created unprecedented opportunities for the treatment ... From American Family Physician, 2/1/05 by Morris Maizels

Common problems in patients recovering from chemical dependency - Practical Therapeutics Chemical dependency is a common, chronic disease that affects up to 25 percent of patients seen in primary care practices. The treatment goal for patients ... From American Family Physician, 11/15/03 by Edna Marie Jones

Quetiapine overdose induced acute respiratory distress syndrome INTRODUCTION: A 41 year-old male, with bipolar disorder presented after ingestion of 4500 mg of quetiapine. Within 24 hours, respiratory failure ensued, ... From CHEST, 10/1/05 by Paul Strachan

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