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Dornase alfa

Dornase alfa (Pulmozyme®) is a highly purified solution of recombinant human deoxyribonuclease I (rhDNase), an enzyme which selectively cleaves DNA. Pulmozyme hydrolyzes the DNA in sputum/mucus of CF patients and reduces viscoelasticity in the lungs, promoting improved clearance of secretions.

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Dornase alfa reduces air trapping in children with mild cystic fibrosis lung disease : a quantitative analysis
Purpose: To evaluate quantitative air trapping measurements in children with mild cystic fibrosis (CF) lung disease during a 1-year, double-blind, placebo-controlled, ...
Dornase alfa therapy in cystic fibrosis: who should get it? - Editorial
Pulmonary disease is the major cause of morbidity and mortality in cystic fibrosis (CF). Soon after birth, thick, viscous secretions accumulate in the ...
Effects of 12-week administration of dornase alfa in patients with advanced cystic fibrosis lung disease - Pulmozyme Study Group
Study objective: The 12-week efficacy and safety of aerosolized recombinant human DNase (dornase alfa) were evaluated in previously untreated patients ...
Computed Tomography Correlates with Pulmonary Exacerbations in Children with Cystic Fibrosis
Rationale: High-resolution computed tomography (HRCT) has been suggested as a potential outcome surrogate for cystic fibrosis (CF) lung disease. An important ...
Pneumothorax in cystic fibrosis
Background: Spontaneous pneumothorax is a complication that is commonly reported in patients with cystic fibrosis (CF). An understanding of the pathophysiology ...
Massive hemoptysis in cystic fibrosis
Background: Massive hemoptysis is a complication commonly reported in patients with cystic fibrosis (CF). An understanding of the pathophysiology of ...
Interventions during donor care before lung transplantation
Improvement in the ratio of PaO^sub 2^ to the fraction of inspired oxygen and treatment of pulmonary infections in donors have been cited as important ...
Device selection and outcomes of aerosol therapy: evidence-based guidelines
Background: The proliferation of inhaler devices has resulted in a confusing number of choices for clinicians who are selecting a delivery device for ...

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