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Dextrorphan

Dextrorphan (DX) is a pharmacologically active metabolite of dextromethorphan (DM). more...

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Chemistry

It is the result of O-demethylation of the prodrug by several enzymatic systems, although it is chiefly a product of the Cytochrome P450 IID6 (CYP4502D6) pathway.

Pharmacology

Being structurally similar to dextromethorphan, and it has affinity for the same receptors in the central nervous system but with a slight difference in selectivity.

Dextromethorphan is a weak non-competitive NMDA receptor antagonist but dextrorphan is a more potent antagonist. DX is a strong anti-tussive, but is slightly less effective than DM, and has no metabolites with significant therapeutic activity in such capacity and therefore is not a drug available on the market.

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Development of an analytical method for dextrorphan (Benjamin F. Fairless memorial lectures) The effects of morphine sulfate, levorphanol tartrate, dextrorphan tartrate and naloxone hydrochloride on arterial blood gases, ph,core temperature and nociception in adult rats

Attenuation of oxidative DNA damage with a novel antioxidant EPC-K1 in rat brain neuronal cells after transient middle cerebral artery occlusion
EPC-KI, L-ascorbic acid 2-[3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-1-benzopyran6-yl-hydrogen phosphate] potassium salt, is a novel ...
Dextromethorphan in Pregnancy - teratogenic potential discussed - Letter to the Editor
To the Editor: We noted with interest the article in CHEST by Einarson et al (February 2001)[1] focusing on the teratogenicity of dextromethorphan.
Dextromethorphan test for evaluation of congenital predisposition to lung cancer
We report the results of an investigation conducted in 992 healthy control subjects (854 adults and 138 adolescents) and in 116 subjects with lung cancer ...

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