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Dapsone

Dapsone is an antibiotic medication most commonly used for the treatment of Mycobacterium leprae infections (leprosy). Dapsone can also be used to treat dermatitis herpetiformis and other skin conditions. It is also sometimes used to prevent Pneumocystis jiroveci pneumonia (PCP) in patients with HIV. more...

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Dapsone is administered orally.

The primary side effect of this drug is anemia, though other side effects, including nausea, headache, and peripheral neuropathy have been known to occur in patients on this medication.

Dapsone is thought to act by depleting the body's stores of para-aminobenzoic acid (PABA).

Read more at Wikipedia.org


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Atrix and Fujisawa submit NDA for topical dapsone gel in the treatment of acne vulgaris
From Journal of Drugs in Dermatology, 11/1/04

Atrix Laboratories and Fujisawa Healthcare have submitted a new drug application to the FDA for Aczone Gel (5% dapsone topical gel), formerly called Atrisone, for the treatment of acne vulgaris.

Aczone uses Atrix's proprietary Solvent Microparticle (SMPTM) delivery system to deliver dapsone, a water-insoluble compound with anti-inflammatory and antimicrobial properties. Dapsone currently is only commercially available for other indications as an oral tablet for systemic delivery due to the compound's water insolubility. Atrix's SMP system allows localized topical delivery of this drug.

COPYRIGHT 2004 Journal of Drugs in Dermatology, Inc.
COPYRIGHT 2005 Gale Group

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