DEET chemical structureDEET is available in many insect repellents
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Diethyltoluamide

DEET (CAS# 134-62-3) is an insect-repellent chemical (Chemical name: N,N-diethyl-meta-toluamide or N,N-diethyl-3-methylbenzamide or Benzamide, N,N-diethyl-3-methyl-). It is intended to be applied to the skin or to clothing, and is primarily used to protect against insect bites. In particular, DEET protects against tick bites (which transmit Lyme disease) and mosquito bites (which transmit dengue fever, West Nile fever and malaria). more...

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DEET was developed by the United States Army, following its experience of jungle warfare during World War II. It entered military use in 1946 and civilian use in 1957.

DEET is the most common active ingredient in insect repellents. Studies into the health effects of DEET have not shown any significant harm to human health (other than for those who are allergic to DEET), but concerns arising from its chemical composition mean that care should be taken in its application. Current mainstream medical opinion is that any dangers posed by DEET are greatly outweighed by those of the serious insect-borne diseases which DEET helps prevent. However, some newer repellents offer alternatives. Repellents containing picaridin or lemon eucalyptus oil were reported by Consumer Reports to be about as effective as repellents containing DEET, though medical studies have differed on the effectiveness of alternatives. A number of tests have shown DEET to be the most effective and longest-lasting insect repellent available.

Because of its relative harmlessness, DEET is often sold and used in concentrations up to 100%. Although this offers the strongest short-term protection against insect bites, it is often not as effective in the long term as formulas containing less DEET (30%-60%). The reason for this is that pure DEET will not long adhere to human skin, and will evaporate, rub, or wash off in time. Formulas with lower concentrations often contain lotions or other agents which allow the formula to adhere to skin longer and provide longer-lasting protection. Any lessening of the strength of the protection as a result of the lower concentration may be countered by applying a greater quantity of the substance. Likewise, pure DEET may be reapplied as necessary to sustain the desired level of repellence.

DEET is believed to work by blocking insect receptors (notably those which detect carbon dioxide and lactic acid) which are used to locate hosts. DEET effectively "blinds" the insect's senses so the biting/feeding instinct is not triggered by humans or animals which produce these chemicals.

DEET can damage some plastics, rayon, spandex, other synthetic fabrics, leather, and painted or varnished surfaces; it does not damage natural fibers, such as cotton or wool, and has no effect on nylon.

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Medications in drinking water
From Townsend Letter for Doctors and Patients, 11/1/04 by Jule Klotter

The presence of very low concentrations of human and animal pharmaceuticals and antibiotics, natural and synthetic hormones, detergents, insecticides, and other 'organic waste-related chemicals' in US streams was documented in a 2002 US Geological Survey. The report identifies 95 chemicals that eventually make their way into our drinking water. Drinking water standards or health advisories have been set for only 81 of the 95 chemicals. Coprostanol (a fecal steroid), N-N-diethyltoluamide (an insect repellant), caffeine, triclosan (an antimicrobial disinfectant), tri (2-chloroethyl) phosphate (a fire retardant), and 4-nonylphenol (a detergent by-product) appeared in the water samples most often.

An update, released in August 2004, says that sewage treatment plants do not remove the chemicals--they are, in fact, part of the problem. Robert Morris, MD, PhD, an environmental health consultant and professor at Tufts University, says, "... Treatment systems were all initially designed to get rid of bacteria and viruses. They have filters and use chlorine, but that doesn't do a whole lot to get rid of chemical contaminants." Among those contaminants are pharmaceuticals that people excrete as well as any unused drugs that people dump into a drain or down the toilet. The amount of chemical contamination in drinking water depends upon the number and the size of the sewage treatment plants that dump effluent into the river or lake which supplies the water. Some areas of the country have more chemicals in their water than others.

No one is sure how--or if--these chemicals affect human health. Robert Morris says, "The presumption has been that the stuff gets so diluted that it won't cause a problem. Whether or not that's true is another issue. People used to think that about microbes and bacteria, and discovered they were pretty wrong about that.... There's evidence that concentrations coming out of treatment plants have an effect on things living in the water. They're obviously going to get the highest exposure. Whether the lower exposure has an effect on humans, we don't know." Herb Buxton, coordinator of the Toxic Substances Hydrology Program, expresses special concern about the presence of antibiotics that may foster antibiotic-resistance in microbes as well as the unknown effect of natural human hormones and synthetic hormones in the water. Synthetic hormones come from birth control pills, hormone supplements, and estrogen-like compounds found in detergents. Although Morris says that "[t]here's no cause for panic," he does recommend that pregnant women or women who are trying to get pregnant drink bottled or filtered water. (Since bottled water may simply be tap water from an unknown source, filtered water seems more appropriate.)

Davis, Jeanie Lerche. Prozac in Drinking Water? Likely So. http://my.webmd.com/content/Article/92/101794.htm

COPYRIGHT 2004 The Townsend Letter Group
COPYRIGHT 2004 Gale Group

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