Diflunisal chemical structure
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Diflunisal

Diflunisal is a generic NSAID (Non Steroidal Anti Inflammatory Drug). It is often used under the brand name Dolobid®. Diflunisal acts by inhibiting the production of prostaglandin, a hormone that creates inflammation and stimulates the neuro receptors for pain. Though Diflunisal has an onset of 1 hour, and maximum analgesia at 2 to 3 hours, the diflunisal plasma levels will not be steady until repeated doesages are achieved. To increase the rate at which the diflunisal plasma levels become steady, a loading dose is usually used. more...

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It is primarily used to treat symptoms of arthritis.

Overdose

Deaths that have occurred from Diflunisal usually involved mixed drugs and or extremely high dosages. The oral LD50 is 500mg/kg. Symptoms of overdose include, coma, tachycardia, stupor, and vomiting. The lowest dose without the presence of other medicines which caused death was 15 grams. Mixed with other medicines, a death at 7.5 grams has also occurred. Diflunisal usually comes in 250 or 500mg, thus it is relatively hard to overdose by accident.

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Faulding subsidiary receives FDA approval to market diflunisal tablets, oral pain and anti-inflammatory drug
From Business Wire, 5/8/96

ELIZABETH, N.J.--(BUSINESS WIRE)--May 8, 1996--Faulding Inc.'s wholly owned subsidiary Purepac Pharmaceutical Co. has received approval from the Food and Drug Administration to market diflunisal tablets, it was announced today by Richard F. Moldin, president and chief executive officer of Faulding Inc.

Diflunisal is an oral non-steroidal drug with analgesic, anti-inflammatory, and antipyretic properties. It is used extensively in the treatment of acute or long-term mild to moderate pain, osteoarthritis, and rheumatoid arthritis.

"Our new 250 mg and 500 mg tablets are the bioequivalent of Dolobid(R) Tablets. Total 1995 brand and generic sales were estimated at nearly $20 million," Moldin said. "This new drug is the second FDA approval received by the company in the last two months," he added.

Faulding Inc. was formerly Purepac, Inc., an oral generic drug producer which changed its name following its recent expansion by acquisition beyond oral drugs into generic injectable drugs and devices. The shares of Faulding Inc. are traded on NASDAQ under the symbol "FAUL." -0- Note: Dolobid(R) is a registered trademark of Merck & Co.

CONTACT: Faulding Inc., Elizabeth

Lee Craker, 908/527-9100

COPYRIGHT 1996 Business Wire
COPYRIGHT 2004 Gale Group

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