Find information on thousands of medical conditions and prescription drugs.

Docusate sodium

Docusate (DAH cue sate) is the generic name of a surfactant used as a laxative and stool softener, which is sold in the U.S. under multiple brand names: Aqualax, Calube, Colace, Colace Micro-Enema, Correctol Softgel Extra Gentle, DC-240, Dialose, Diocto, Dioctocal, Dioctosoftez, Dioctyn, Dionex, Doc-Q-Lace, Docu Soft, Docucal, Doculax, Docusoft S, DOK, DOS, Doss-Relief, DSS, Ex-Lax Stool Softener, Fleet Sof-Lax, Genasoft, Kasof, Modane Soft, Octycine-100, Regulax SS, Sulfalax Calcium, Sur-Q-Lax, Surfak Stool Softener and Therevac-SB. more...

Home
Diseases
Medicines
A
B
C
D
Dacarbazine
Dactinomycin
Dalmane
Danazol
Dantrolene
Dapoxetine
Dapsone
Daptomycin
Daraprim
Darvocet
Darvon
Daunorubicin
Daunorubicin
Daypro
DDAVP
Deca-Durabolin
Deferoxamine
Delsym
Demeclocycline
Demeclocycline
Demerol
Demulen
Denatonium
Depakene
Depakote
Depo-Provera
Desferal
Desflurane
Desipramine
Desmopressin
Desogen
Desogestrel
Desonide
Desoxyn
Desyrel
Detrol
Dexacort
Dexamethasone
Dexamfetamine
Dexedrine
Dexpanthenol
Dextran
Dextromethorphan
Dextromoramide
Dextropropoxyphene
Dextrorphan
Diabeta
Diacerein
Diacetolol
Dial
Diamox
Diazepam
Diazoxide
Dibenzepin
Diclofenac
Diclohexal
Didanosine
Dieldrin
Diethylcarbamazine
Diethylstilbestrol
Diethyltoluamide
Differin
Diflucan
Diflunisal
Digitoxin
Digoxin
Dihydrocodeine
Dihydroergotamine
Dihydrotachysterol
Dilantin
Dilaudid
Diltahexal
Diltiazem
Dimenhydrinate
Dimercaprol
Dimetapp
Dimethyl sulfoxide
Dimethyltryptamine
Dimetridazole
Diminazene
Diovan
Dioxybenzone
Diphenhydramine
Diphenoxylate
Dipipanone
Dipivefrine
Diprivan
Diprolene
Diproteverine
Dipyridamole
Disulfiram
Disulfiram
Dizocilpine
Dobutamine
Docetaxel
Docusate sodium
Dofetilide
Dolasetron
Dolobid
Dolophine
Domperidone
Donepezil
Dopamine
Dopram
Doral
Doramectin
Doriden
Dornase alfa
Doryx
Dostinex
Doxapram
Doxazosin
Doxepin
Doxil
Doxil
Doxorubicin
Doxy
Doxycycline
Doxyhexal
Doxylamine
Drisdol
Drixoral
Dronabinol
Droperidol
Drospirenone
Duloxetine
Durabolin
Duragesic
Duraphyl
Duraquin
Dutasteride
Dv
Dyclonine
E
F
G
H
I
J
K
L
M
N
O
P
Q
R
S
T
U
V
W
X
Y
Z

Docusate is also any of a group of anionic surfactants widely used as emulsifying, wetting, and dispersing agents.

Clinical use

Docusate is given to make stools softer and easier to pass. It is used to treat constipation due to hard stools, in painful anorectal conditions such as hemorroids, and for people who should avoid straining during bowel movements. Of note is that that effect of docusate may not necessarily be all due to its surfactant properties. Perfusion studies suggest that docusates inhibit fluid absorption or stimulate secretion in jejunum.

While the use of docusate is widespread, the data to support its efficacy in treating chronic constipation is actually lacking. Although more research is needed, long term use of docusate seems to decrease levels of magnesium and potassium in the blood.

Presentations

  • Docusate is available in tablet, capsule, liquid and rectal enema.
  • Docusate calcium and docusate potassium are anionic surfactants used as stool softeners and are administered orally.
  • Docusate sodium is anionic surfactant used as a stool softener and is administered orally or rectally; as a tablet disintegrant or as an emulsifier and dispersant in topical preparations. When sold as Colace, it is docusate sodium, or sodium salt of dioctyl sodium sulfosuccinate (DSS). Some metabolism studies show that DSS is absorbed by the body from the gastrointestinal tract, undergoing extensive metabolism. In humans, the main way DSS metabolites are extreted is via the feces.

Effect

  • The effect on stools is seen 1 to 3 days after the first dose.

Read more at Wikipedia.org


[List your site here Free!]


Handling constipation and fecal impaction
From Nursing Homes, 4/1/05 by Linda Williams

As staff at most nursing facilities are aware, the occurrence of a resident having a fecal impaction is considered a sentinel event by the Centers for Medicare & Medicaid Services. It causes hardship for the resident and also for the staff, when their interventions are scrutinized by state surveyors to determine whether the event could have been avoided. Sometimes this same scrutiny and analysis find their way into a courtroom. Please take the time to review the circumstances surrounding the following situation, and make changes as appropriate at your facility.

The Situation

A 56-year-old woman was admitted to a skilled nursing facility with the following diagnoses: anemia, gastroesophageal reflux disease, Alzheimer's disease, severe multiple sclerosis, anxiety, contractures of all extremities, and reddened areas on her knees and one heel. For three years, the woman had been unable to move her upper and lower extremities voluntarily, so she had a urinary catheter and was subject to frequent fecal impactions. Before moving to the nursing facility, she had lived with her son while receiving home healthcare.

Because of the woman's frail condition, her physician wrote orders for the staff to encourage her to drink 3,000 cc of fluid each day. An enema also was to be given, up to three times per week, as needed. These and other constipation-prevention measures were incorporated into the woman's plan of care.

While at the facility, the woman's condition began to deteriorate. On her 23rd day of residence, the woman's urinary catheter began to leak, so she was transferred to the emergency room at her son's request.

The woman was admitted to the hospital with the following diagnoses: urinary tract infection with sepsis, dehydration, renal insufficiency, and high fecal impaction.

Three weeks after admission, the woman suffered acute abdominal pain, which proved to be a diverticular abscess, requiring a colostomy for relief. Three days after surgery, she seemed to be improving when she suddenly aspirated and died. Two months later, the woman's son sought legal counsel and filed a suit against the facility for his mother's wrongful death because of negligent care. His demand to settle was $3 million.

Upon examination of the woman's medical records at the nursing facility, both the plaintiff and defense attorneys discovered that the woman only had two bowel movements during her 23-day stay: One occurred two weeks after admission and the other was the day before being discharged to the hospital. In addition, the records revealed that during her last 48 hours at the facility, she consumed only 600 cc of fluids yet had a urine output of 2,000 cc. Other chart entries did not look much better, as her fluid intake during each of the previous days was less than half of the recommended 3,000 cc, and there was no dietary evaluation or notes concerning her meal intake.

Both attorneys hired expert witnesses to review the case and offer their medical opinions. The defense hired a geriatric specialist who felt that the woman's death was not causally related to the treatment she received at the nursing facility. However, the plaintiff's medical expert held an opposing view and felt there was indeed a direct link, especially related to the lack of monitoring, which led to the high fecal impaction. The parties went to mediation and agreed on a settlement of $500,000.

What Went Wrong

Undeniably, the defense's weakest point was that the staff did not pay close enough attention to the woman's bowel regularity patterns and did not intervene sooner (as directed by her plan of care) before the fecal impaction crisis struck. Medically speaking, individuals are considered to be constipated if bowel movement frequency is fewer than three times per week and/or if straining is experienced with more than 25% of bowel movements. Residents who are at risk for constipation include those with:

* limited physical activity;

* recent abdominal or perianal surgery or general anesthesia;

* inadequate diet (e.g., less than 15 grams of dietary fiber per day);

* inadequate fluid intake (e.g., less than 1,000 cc per day);

* use of drugs known to be associated with constipation (e.g., anticholinergics, tricyclic antidepressants, antiemetics, antihistamines, anti-Parkinson agents, antipsychotics/phenothiazines, antacids containing aluminum, analgesics/nonsteroidal antiinflammatory drugs [NSAIDs], barium, bismuth, diuretics, histamine-2 blockers, hypotensives, iron supplements, opioids/narcotics, and phenytoin);

* chronic constipation history;

* laxative abuse history; and/or

* comorbidities known to be associated with constipation (e.g., renal failure, electrolyte imbalances, spinal cord injury, arthritis, heart disease, diverticular disease, inflammatory bowel syndrome, colon cancer, painful lesions in the rectal or anal region, obstructing neoplasms, Parkinson's disease, amyotrophic lateral sclerosis, multiple sclerosis, myotonic dystrophy, stroke, insulin-dependent diabetes mellitus, untreated hypothyroidism, hyperparathyroidism, hypercalcemia, and symptoms of depression, dementia, psychosis, and acute confusion).

The woman in this case study had many of these risk factors, just as a significant percentage of residents that reside in nursing facilities today do. For this reason, it is important for staff to take the following precautions, as recommended by the University of Iowa in Evidence-Based Protocol: Management of Constipation, to minimize the occurrence of a similar crisis in their facility:

1. Identify residents at risk for constipation by using a standardized assessment tool to determine a resident's constipation risk factors. This should be done upon admission, routinely, and whenever there is a change in cognition or functional ability. "The Management of Constipation Assessment Inventory" form developed by the University of Iowa is an excellent tool. It can be found in Evidence-Based Protocol: Management of Constipation (contact the university's Nursing Research Department at [319] 384-4429 for more information).

2. Implement a prevention program that includes all of the following, as indicated:

* Fluid intake. The dietitian should perform an assessment to calculate the fluid needs of the resident. Fluid intake of at least 1.5 liters per day is recommended to avoid constipation, unless contraindicated. Water is preferred, although other fluids such as juices are beneficial. Coffee, tea, and alcohol should be avoided because of their diuretic properties.

* Diet. The most beneficial means to prevent constipation is a combination of insoluble and soluble fiber by increasing dietary intake of bran, fruits, and vegetables. Recommendations for dietary fiber intake vary from 25 to 30 grams per day. The dietitian should assess and recommend the amount of fiber intake for each resident at risk for constipation. Fiber supplements such as "power pudding" also may be used in combination with a high-fiber diet.

* Physical activity. Activity recommendations should be tailored to the individual's physical abilities and health condition. Walking 15 to 20 minutes once or twice a day (or more) as tolerated is recommended for those who are fully mobile. Ambulating at least 50 feet twice a day is recommended for individuals with limited mobility. For individuals unable to walk or who are restricted to bed rest, chair or bed exercises--such as pelvic tilt, low trunk rotation, and single leg lifts--are recommended.

* Toileting. Establishing a routine toileting pattern has been found to be beneficial in the management of constipation.

* Laxatives. Laxatives may be considered at any time if there is no bowel movement for more than three days. For chronic constipation (longer than six months), laxative use is advocated only as a supplement to the above regimen of adequate fluid intake, high-fiber diet, exercise, and toileting routine.

3. A daily bowel movement record should be kept for all dependent residents to track regularity and assess the need for interventions. All CNAs should document whether the residents they provided care for had a bowel movement. The charge nurse should look at the record each shift and initiate interventions as appropriate.

4. If the resident has not had a significant bowel movement for three days, laxative treatment is necessary, per physician order. A stepwise progression of laxative treatment is recommended. Once constipation is resolved, management should be moved to the top of the laxative pyramid. The following steps are recommended, from first to last:

* fluid, fiber, and exercise (see above);

* bulk-forming laxatives;

* stool softeners (e.g., docusate sodium);

* osmotic laxatives (e.g., lactulose or magnesium sulfate);

* stimulants (e.g., senna);

* suppository/enema (e.g., bisacodyl or sodium/potassium phosphate enema); and

* fecal impaction removal--should be performed as a last resort and only after all other interventions have failed, per physician discretion.

Finally, the resident's physician should be notified of any new patterns of constipation. This includes a previously regular resident who has a bowel movement less than three times per week and/or straining with more than 25% of bowel movements, or if a resident with chronic constipation is uncontrolled to the extent of fecal impaction removal.

By taking these necessary precautions, you have the ability to protect your residents and facility, now and into the future.

BY LINDA WILLIAMS, RN

Linda Williams, RN, is a Long-Term Care Risk Manager for the GuideOne Center for Risk Management's Senior Living Communities Division. She previously served as Director of Nursing in a CCRC and as a nurse consultant for two corporations with numerous long-term care facilities in Iowa. The GuideOne Center for Risk Management is dedicated to helping churches, senior living communities, and schools/colleges safeguard their communities by providing practical and timely training and resources on safety, security, and risk-management issues. For more information, contact Williams at (877) 448-4331, ext. 5175, or slc@guideone.com, or visit www.guideonecenter.com. To send your comments to the author and editors, please e-mail williams0405@nursinghomesmagazine.com. To order reprints in quantities of 100 or more, call (866) 377-6454.

COPYRIGHT 2005 Medquest Communications, LLC
COPYRIGHT 2005 Gale Group

Return to Docusate sodium
Home Contact Resources Exchange Links ebay