Stability of dolasetron in two oral liquid vehicles.
Johnson CE, Wagner DS, Bussard WE. Am J Health Syst Pharm 2003; 60(21): 2242-2244.
A liquid oral formulation of dolasetron mesylate, a potent antiemetic, would be useful for pediatric and adult patients who require nonStandard dosages or who are unable to swallow tablets. The authors describe the preparation of a liquid suspension of dolasetron mesylate from crushed 50-mg tablets and a 1:1 mixture of Ora-Plus with either strawberry syrup or Ora-Sweet SF. The physical and chemical stability of this 10-mg/mL suspension stored in 2-oz amber plastic bottles at 23° to 25°C and 3° to 5°C was determined over 90 days. The concentration of dolasetron mesylate in each sample was at least 98% of the initial concentration throughout the 90-day study period. No changes in color, odor or taste were detected, and there was no visible microbial growth. Because of the slightly bitter aftertaste of dolasetron mesylate, the authors recommend that chocolate syrup be used to improve palatability of the suspension for children.
Copyright International Journal of Pharmaceutical Compounding May/Jun 2004
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