Doxorubicin chemical structure
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Doxil

Doxorubicin or adriamycin is a DNA-interacting drug widely used in chemotherapy. It is an anthracycline and structurely closely related to daunomycin, and also intercalates DNA. It is commonly used in the treatment of uterine cancer and ovarian cancer, as well as some other cancers. more...

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Doxil® is a liposome-encapsulated dosage form of doxorubicin made by Johnson & Johnson. Its main benefits are a reduction in cardiotoxicity. It follows the similar preparation of daunorubicin in a liposomal carrier.

Mechanism of Action

Doxorubicin acts by binding to DNA where it can inhibit the progression of the enzyme topoisomerase II, which unwinds DNA for transcription. Doxorubicin stabilises the topoisomerase II complex after it has broken the DNA chain for replication, preventing the DNA double helix from being resealed and thereby stopping the process of replication.

Side Effects

Acute side-effects of doxorubicin are nausea, vomiting, decrease in white blood cells and hair loss. When the cumulative dose of doxorubicin reaches 450mg/m2, the risk of congestive heart failure dramatically increases.

Clinical Use

Doxorubicin is a commonly used to treat Hodgkins disease, breast cancer, lung cancer, soft tissue sarcoma, Kahlers disease.

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Johnson & Johnson to acquire Alza for 15.08 times revenue
From Weekly Corporate Growth Report, 4/2/01

The Deal: Johnson & Johnson has agreed to purchase Alza Corp. for $12 billion in stock. The acquisition is a move by Johnson & Johnson to gain several fast-selling drugs and technology that can improve medicines. After news of the transaction was announced, shares of Johnson & Johnson fell $2.13 to $83.25, while Alza shares rose 25 cents to close at $39.

Discussion: Alza designs controlled-dosage drug-delivery systems, which range from skin patches to low-current electric devices that administer drugs through the skin. Key drugs that use Alza's technology include Procardia XL oral angina/hypertension treatment, number one smoking cessation patch NicoDerm CQ and over-the-counter allergy medication Sudafed 24. Alza also develops drugs for its own account, including Ditropan XL for overactive bladder, and cancer treatment Doxil.

Johnson & Johnson is one of the world's largest, most diversified health care product makers. The company operates in three sectors: Consumer products such as Tylenol and Motrin analgesics, Reach toothbrushes and Band-Aid bandages; professional products like ACUVUE contact lenses, surgical instruments and joint replacements; and pharmaceuticals such as Ergamisol cancer treatment and Ortho-Novum oral contraceptives.

Copyright NVST.com, Inc. Apr 2, 2001
Provided by ProQuest Information and Learning Company. All rights Reserved

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