QV Nandrolone Deca, a form of nandrolone abused by atheletes.

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Durabolin

Nandrolone is an anabolic steroid occurring naturally in the human body, albeit in small quantities. Nandrolone is most commonly sold commercially as its decanoate ester (Deca-Durabolin) and less commonly as a phenylpropionate ester (Durabolin). Nandrolone use is indirectly detectable in urine tests by testing for the presence of 19-norandrosterone, a metabolism product of this molecule. The International Olympic Committee has set a limit of 2 ng per ml of urine as the upper limit, beyond which an athlete is suspected of doping. more...

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Urine analysis as a method of detecting nandrolone abuse has recently become somewhat controversial, following studies by the University of Aberdeen showing that the metabolite product can also show up in urine in quantities above the upper limit from a combination of high-protein diets utilising the legal nutritional supplement creatine and hard cardiovascular exercise. The reason for this unexpected result has not been determined. Another possible (though unlikely) reason for a false positive result is the consumption of beef from cattle treated with steroids including nandrolone (used in overturning the verdict against the bobsleigh racer, Lenny Paul). A final possible cause of incorrect urine test results is the prescence of metabolites from other anabolic steroids. However, as all such substances are also banned, this source is somewhat insignificant when interpreting the results of such a test. As a result of the numerous overturned verdicts, the testing procedure was reviewed by UK Sport in 2000.

Nandrolone binds to the androgen receptor to a greater degree than testosterone, but due to its inability to act on the muscle in ways unmediated by the receptor, has less overall effect on muscle growth. The drug is also unusual in that unlike most anabolic steroids, it is not broken down into the more reactive DHT by the enzyme 5α-reductase, but rather into a less effective product. As such, some of the negative effects associated with most such drugs are somewhat mitigated.

The positive effects of the drug include muscle growth, appetite stimulation and increased red blood cell production and bone density. Clinical studies have shown it to be effective in treating anaemia, osteoporosis and some forms of neoplasia including breast cancer, and also acts as a progestin-based contraceptive. For these reasons, nandrolone received FDA approval in 1983, and while sale is now restricted by the Controlled Substances Act, it remains available by prescription in most countries. In addition to legal production, Nandrolone is also extensively produced and used illegally by athletes and bodybuilders seeking an edge in professional competition.

Because nandrolone is not broken down into DHT, the deleterious effects common to most anabolic steroids on the scalp, skin, and prostate are lessened to a degree. The lack of alkylation on the 17α-carbon drastically reduces the drug's liver toxicity. Estrogenic effects resulting from reaction with aromatase are also mitigated as a result of the drug being a progestin, but effects such as gynaecomastia and reduced libido still occur in larger doses. Other side-effects can include erectile dysfunction and cardiovascular damage, as well as several ailments resulting from the drug's effect of lowering levels of luteinizing hormone through negative feedback.

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Supplements risky business for players
From Gazette, The (Colorado Springs), 9/8/04 by FRANK SCHWAB THE GAZETTE

ENGLEWOOD - Steroids and supplements have become practically interchangeable terms by NFL fans and the NFL, which has sections regarding supplements in its steroid policy.

In fact, the NFL probably wouldn't mind if supplements went away for good.

"For your own health and success in the league, we strongly encourage you to avoid the use of supplements altogether, or at the very least to be extremely careful about what you choose to take," the NFL and NFL Players Association said in a co-authored statement on the NFLPA's Web site.

But supplements are part of the scene after any Broncos workout. Defensive end Bryant McNeal drinks a protein shake after lifting weights. Cornerback Lenny Walls has a sports drink with electrolytes added to it. Linebacker Terry Pierce talks about the seven multi- vitamins he takes daily.

Unlike steroids, some supplements are legal, help athletes without dire side effects and are readily available to the public in stores. Supplements themselves, which enhance a player's nutrition before or after workouts when used properly, aren't necessarily the problem. For many, it is a way to get a boost of protein or vitamins to accentuate the work they've done in the weight room.

The trepidation is over taking a supplement with a banned substance in it, and there are many that have been outlawed. The NFLPA lists 34 anabolic steroids, 19 masking agents and six stimulants on its main list of banned substances. If a player tests positive for one, he is immediately suspended for four games.

Players such as Carolina Panthers defensive end Julius Peppers, former Chicago Bears quarterback Jim Miller and former Pittsburgh Steelers and Broncos safety Lee Flowers were suspended for violating the policy. All said afterward that they took a nutritional supplement that they did not know had a banned substance in it.

Flowers said last year he bought some vitamins at a well-known store that sells nutritional supplements. He said he tested positive for ephedra, although it was not listed on the bottle's ingredients. The Broncos released Flowers after his suspension was over, and he never played for Denver.

The ephedra Flowers took could have shown up in the ingredients under another name, such as Ma Huan, or the label may not have been accurate. In the NFLPA's warning about supplements, one of its main concerns is that the government doesn't regulate or monitor supplements.

"I would not tell a player to go to a nutritional store and get something because you don't know what's in it," Broncos strength and conditioning coach Rich Tuten said. "You don't know. There might be something disguised in there that has ephedra in it, and then you test positive."

The NFL has taken steps to help players feel safe about taking supplements. The league instituted a "Supplement Certification Program" in January, in which an independent organization tests supplements from participating companies before they hit the market and randomly after they are in stores to verify the accuracy of the ingredients and make sure no banned substances are included.

A few months after the program was instituted, EAS was the only company that passed all the tests. The Coloradobased company provided nutritional supplements to NFL teams, including protein - rich shakes, powders and snack bars.

If the supplements are administered and monitored properly, it could help players with their offseason workout regimen without worrying about getting a four-game suspension from the league for testing positive for a banned substance.

"Our view, and I think it's shared by the league and the (players association), is that improved nutrition is the next major area of development for athletes," said Chip Bellamy, general counsel for EAS. "They all know about strength training, and many of them don't know or pay enough attention to nutrition."

CONTACT THE WRITER: 476-4891 or fschwab@gazette.com

BANNED SUBSTANCES

The following substances areprohibited by the NFL:

Anabolic/androgenic steroids

Androstenediol (Androstederm)

Androstenedione (Androstan, Androtex)

Bolasterone (Myagen)

Boldenone (Equipoise, Parenabol)

Clostebol (Turinabol, Steranabol)

Danazol (Cyclomen, Danatrol)

Dehydrochlormethyltestosterone (Oral-Turinabol)

Dehydroepiandrosterone (DHEA)

Dihydrotestosterone (DHT, Stanolone)

Dromostanolone (Drolban)

Ethylestrenol (Maxibolin, Orabolin)

Fluoxymesterone (Halotestin)

Formebulone (Esiclene, Hubernol)

Furazabol (Miotolon)

Gestrinone (Tridomose)

17-Hydroxypregnenedione

17-Hydroxyprogesterone

Mesterolone (Proviron)

Methandienone (Danabol, Dianabol)

Methandriol (Androdiol)

Methandrostenolone (Dianabol)

Methenolone (Primobolan)

Methyltestosterone (Metandren)

Mibolerone (Testorex)

19-Norandrostenediol (19-Diol)

19-Norandrostenedione (19 Nora Force)

Norethandrolone (Nilevar)

19-Nortestosterone (Nandrolone)

Deca-Durabolin

Oxymesterone (Oranabol)

Oxymetholone (Anadrol)

Progesterone-Stanozolol (Stromba, Winstrol)

Testosterone (Andronate)

Trenbolone (Finaject) Human or animal growth hormone

Beta-2-agonists (Clenbuterol, etc.)

Human chorionic gonadatropin Masking agents (24 listed) Stimulants

Ephedrine (Ma Huan, Chi Powder)

Methylephedrine

Pseudophedrine (found in Sudafed and Actifed, which are allowed when prescribed by team doctors)

Fenfluramine (Phen-Fen, Redux)

Norfenfluramine-Phentermine (Fastin, Adipex, Ionamin)

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