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Gabitril

Tiagabine (IUPAC name 1-piperidine-3- carboxylic acid hydrochloride) is an anti-convulsive medication produced by Cephalon and marketed under the brand name Gabitril.

Though the exact mechanism by which tiagabine exerts its effect on the human body is unknown, it does appear to operate as a selective GABA reuptake inhibitor.


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New labeling
From Geriatrics, 4/1/05

Tiagabine (Gabitril, Cephalon) labeling change to warn of seizure risk associated with the drug when used off-label to treat patients without epilepsy.

Rosuvastatin (Crestor, AstraZeneca) labeling change to warn that rhabdomyolysis may occur as a result of its use, especially in patients taking cyclosporine, in North Americans of Asian descent, and those with severe renal deficiency. A warning of jaundice was also added.

Anagrelide (Angrylin; Mallinckrodt, Roberts) labeling change regarding contraindications including its use in patients with severe hepatic impairment. Dosage reduction recommended in patients with moderate hepatic impairment and monitoring for cardiovascular effects.

Darbepoetin alfa (Aranesp, Amgen) labeling change to warn kidney dialysis and cancer patients that studies on similar drugs showed that higher doses can cause blood clots and death.

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COPYRIGHT 2005 Gale Group

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