Find information on thousands of medical conditions and prescription drugs.

Glibenclamide

Glibenclamide is a class of drug known as sulfonylureas. Sulfonylureas are used to treat Type II diabetes. The drug works by inhibiting ATP-ase dependent sodium channels in pancreatic beta cells. The inhibition causes an influx of calcium into the beta cell which stimulate insulin release.

The drug is contraindicated in pregnant women. It is also a major cause of drug induced hypoglycaemia.

Home
Diseases
Medicines
A
B
C
D
E
F
G
Gabapentin
Gabitril
Galantamine
Gamma-hydroxybutyrate
Ganciclovir
Garamycin
Gaviscon
Gemcitabine
Gemfibrozil
Gemhexal
Gemzar
Generlac
Gentamicin
Geodon
Gleevec
Gliadel
Gliadel Wafer
Glibenclamide
Glimepiride
Glipizide
Glucagon
Glucobay
Glucohexal
Glucophage
Glucosamine
Glucotrol
Glutethimide
Golytely
Gonadorelin
Goserelin
Gramicidin
Gramicidin S
Granisetron
Grifulvin V
Griseofulvin
Guaifenesin
H
I
J
K
L
M
N
O
P
Q
R
S
T
U
V
W
X
Y
Z

Read more at Wikipedia.org


[List your site here Free!]


Beneficial effects of Momordica charantia seeds in the treatment of STZ-induced diabetes in experimental rats
From Alternative Medicine Review, 9/1/05 by D. Sathishsekar

Beneficial effects of Momordica charantia seeds in the treatment of STZ-induced diabetes in experimental rats.

Sathishsekar D, Subramanian S. Biol Pharm Bull 2005;28:978-983.

The aim of the present study was to evaluate the effect of the aqueous extract of seeds of two varieties, namely a country and hybrid variety of Momordica charantia (MCSEtl and MCSEt2) on oxidative stress in plasma and pancreas of streptozotocin (STZ) induced diabetic rats. Oral administration of each of the seed extracts at a dosage of 150 mg/kg body weight for 30 d resulted in a significant reduction in plasma glucose, thiobarbituric acid-reactive substances, lipid-hydroperoxides, alphatocopherol and significant improvement in ascorbic acid, reduced glutathione and insulin. The treatment also resulted in a significant reduction in thiobarbituric acid reactive substances, lipid-hydroperoxides, superoxide dismutase, catalase, glutathione peroxidase and significant improvement in reduced glutathione in pancreas of drug treated diabetic rats when compared to the untreated diabetic rats. On the basis of results obtained, it may be concluded that the treatment of Momordica charantia seed varieties may effectively normalize the impaired oxidative stress in streptozotocin induced-diabetes than the glibenclamide treated groups.

COPYRIGHT 2005 Thorne Research Inc.
COPYRIGHT 2005 Gale Group

Return to Glibenclamide
Home Contact Resources Exchange Links ebay