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Glibenclamide

Glibenclamide is a class of drug known as sulfonylureas. Sulfonylureas are used to treat Type II diabetes. The drug works by inhibiting ATP-ase dependent sodium channels in pancreatic beta cells. The inhibition causes an influx of calcium into the beta cell which stimulate insulin release.

The drug is contraindicated in pregnant women. It is also a major cause of drug induced hypoglycaemia.

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Type 2 Diabetes - Glucovance now initial therapy
From Family Pratice News, 2/15/01

Glucovance (glyburide and metformin HCl tablets) is now indicated as initial therapy in addition to diet and exercise, to improve glycemic control in patients with type 2 diabetes whose hyperglycemia cannot be satisfactorily managed with diet and exercise alone.

COPYRIGHT 2001 International Medical News Group
COPYRIGHT 2001 Gale Group

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