Find information on thousands of medical conditions and prescription drugs.

Goserelin

Goserelin is an injectable gonadotropin releasing hormone agonist (GnRH agonist). It stops the production of sex hormones (testosterone and oestrogen) and is used to treat hormone-sensitive cancers of the prostate and breast (in pre-/perimenopausal women) and some benign gynaecological disorders (endometriosis, uterine fibroids and endometrial thinning). In addition, goserelin is used in assisted reproduction. more...

Home
Diseases
Medicines
A
B
C
D
E
F
G
Gabapentin
Gabitril
Galantamine
Gamma-hydroxybutyrate
Ganciclovir
Garamycin
Gaviscon
Gemcitabine
Gemfibrozil
Gemhexal
Gemzar
Generlac
Gentamicin
Geodon
Gleevec
Gliadel
Gliadel Wafer
Glibenclamide
Glimepiride
Glipizide
Glucagon
Glucobay
Glucohexal
Glucophage
Glucosamine
Glucotrol
Glutethimide
Golytely
Gonadorelin
Goserelin
Gramicidin
Gramicidin S
Granisetron
Grifulvin V
Griseofulvin
Guaifenesin
H
I
J
K
L
M
N
O
P
Q
R
S
T
U
V
W
X
Y
Z

It is available as a 1-month depot and a long-acting 3-month depot. Both depots are used for the treatment of prostate cancer, endometriosis and uterine fibroids but only the 1-month depot is approved for breast cancer, endometrial thinning and assisted reproduction.

Goserelin is marketed by AstraZeneca with the brand name Zoladex. It was first launched in 1987 and is currently the second-largest selling LHRHa in the world. It is currently available in more than one hundred markets.

Side effects

Goserelin causes an increase in bone pain and symptoms of prostatic cancer during the first few weeks of treatment. As your body adjusts to the medication, the symptoms will disappear. Goserelin may cause hot flashes, headache, stomach upset, difficulty urinating, weight gain, swelling and tenderness of breasts, decreased erections, reduced sexual desire.

Read more at Wikipedia.org


[List your site here Free!]


AstraZeneca to pay $355 million fine - Updates
From FDA Consumer, 9/1/03

AstraZeneca Pharmaceuticals LP of Wilmington, Del., has agreed to pay a $355 million fine to resolve criminal charges and civil liabilities stemming from an illegal marketing and pricing scheme involving a drug to treat prostate cancer. The massive conspiracy involving the drug Zoladex (goserelin acetate) caused multimillion-dollar losses for federally and state-funded insurance programs and patients.

The FDA's Office of Criminal Investigations (OCI) discovered that AstraZeneca employees were using illegal methods to stimulate the demand for Zoladex by enabling physicians to reap illicit profits.

In one of these schemes, AstraZeneca provided thousands of free samples to physicians, knowing they would charge their patients and insurance programs for them. Another illegal inducement used by the firm involved inflating the price of Zoladex reported to Medicare as the basis for reimbursement, while deeply discounting the actual price charged to physicians. AstraZeneca also misreported and underpaid the Medicaid rebates it owed to the states for the use of Zoladex.

"FDA will not tolerate criminal conduct that exploits patients, plunders the national treasury, and adds to the cost of health care," says FDA Commissioner Mark B. McClellan, M.D., Ph.D. The FDA's OCI was joined by representatives of the U.S. Attorney's Office for the District of Delaware, the Department of Health and Human Services, and the Defense Criminal Investigative Service in announcing the guilty plea in June. The Federal Bureau of Investigation was also involved with the case.

The investigation resulted in charges against three physicians of conspiring with AstraZeneca to bill patients and third-party payers for free Zoladex samples.

COPYRIGHT 2003 U.S. Government Printing Office
COPYRIGHT 2004 Gale Group

Return to Goserelin
Home Contact Resources Exchange Links ebay