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Grifulvin V

This is a common brand name for the medication Griseofulvin (GRISS-ee-oh-FULL-vin). It is used to treat fungal and yeast infections of the skin, hair, fingernails and toenails. Particularly ringworm, athlete's foot, jock itch, sweat rash, intertrigo (skin crease infection), and many other fungal infections. more...

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Other Common Brand Names for Griseofulvin

Fulvicin, Gifulvin V, Gris-Peg, Grisactin

Uses

Taken as an oral tablet. Best taken with a meal that has a high fat content. It may take from several days to several months for treatment to be completed, depending on type and location of infection. Medication is taken in full prescribed amount until finished even if symptoms have disappeared for a few days. Stopping or missing medicaition may allow infection to re-occur.

Side Effects

Headache, diarrhea, gas, nausea, fatigue, vomiting, dizziness, trouble sleeping, increased sunlight sensitivity, (sunburn-like effect) may occur. If side effects worsen, doctor should be contacted promptly. Immediately contact doctor if the following occurs: yellowing of the eyes or skin, signs of infection (e.g., fever, chills, persistent sore throat), soreness of the mouth or tongue, mental/mood changes, tingling or numbess of the hands/feet. In the unlikely event of an allergic reaction, seek immedate medical attention. Symptoms of an allegic reaction: trouble breathing, skin rash, itching, hives, swelling, severe dizziness. If any other effects are noticed contact doctor immediately.

Precautions

Medication should be avoided if patient has a blood disorder or a severe liver disease(hepatic failure). Alcoholic beverages should be avoided while drug is taken, unless doctor approves permission. Drinking alcohol can result in rapid heart rate and flushing of the skin. Griseofulvin may increase sunlight sensitivity, and sunlight should be avoided, or sunscreen and protective clothing worn.

Pregnancy Warning

This drug interferes with birth control pills. This drug is not to be used during conception of children. It should not be used while pregnant and it has harmful effects on the human sperm and can cause birth defects. Males should wait at least six months after medication before fathering of children. This drug may also pass into breast milk.

Drug Interactions

Doctor should evaluate each and every prescription and over the counter drug before treatment. Especially the blood thinners heparin and wafarin.

Overdose

If overdose is suspected contact the US national poison control hotline at 1-800-222-1222 or your nations poison control.

Notes

Dry it, treat it, and prevent it.

Avoid goopy wet creams at all costs, wetness and warmth are the breeding grounds for the infections. Use dry powders and keep well ventillated.

Zeabsorb AF antifungal lotion/powder is unique in helping intertrigo and other fungal infections. Wrapping the powder in a handkerchief and patting the affected areas helps. Corn Starch can be substituted for a powder. Raw spots should be treated with an antibacterial ointment such as Neosporin or Polysporin. Astringent drying agents like Domeboro astringent solution may be applied 20 minutes daily to help. Bras should be worn only when necessary. Clean and dry clothing and bedding are important in fighting fungus and yeast, avoid the laundromat or other public places such as a gym were this infection spreads. Oral anti-yeast medication such as Diflucan. Baby diaper rash drying creams and powders can be useful.

Read more at Wikipedia.org


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Drug update: oral antifungal drugs - Clinical Rounds
From OB/GYN News, 1/15/04 by Robert Finn

Oral antifungals are used to treat both skin and systemic infections. For skin infections, oral antifungals are most commonly used to treat patients who have not responded to topical formulations, although an oral drug is sometimes used from the start, such as in some cases of tinea capitis. Most fungal skin infections are caused by dermatophytes, and terbinafine is the top drug for these pathogens.

Systemic fungal infections most frequently occur in patients who are immunocompromised as a result of HIV infection or transplant immunosuppression, among other reasons. Oral drugs can be effective for milder infections that don't require intravenous treatment. For these infections, fluconazole is the top choice.

Treatment of fungal infections is generally empiric; little identification of the pathogen is done in routine practice. As a result, the top drugs are usually tried first, with second-line agents used as needed. Dosing schemes for oral antifungals vary depending on the conditions for which they're prescribed. Pulse dosing has been suggested for some agents, including terbinafine and itraconazole, especially for treating onychomycosis. In such a regimen the patient receives twice the normal dose every day for a week and then goes off the drug for 3 weeks, after which the cycle is repeated. Some physicians prefer continuous dosing because they believe that compliance is better with a simpler regimen.

Two new drugs in the azole class, posaconazole and ravuconazole, are under development, but Food and Drug Administration approval will probably not occur before late 2004.

All listed drugs can be used in elderly patients with no need for a systematic dosage adjustment, but some of them should not be used in patients with liver or kidney dysfunction.

While the risk to the developing embryo or fetus appears to be low for most oral antifungals, fluconazole 400 mg/day during the first trimester has caused birth defects. Because therapy usually involves prolonged treatment, it is best to avoid all antifungals during the first 12 weeks' gestation if this does not jeopardize the mother's condition. Among the oral antifungals, terbinafine appears to have the lowest potential for harm during pregnancy, but there are no human data.

Nursing mothers should not use most oral antifungals because of the risk of serious toxicity to the infant. Fluconazole is the only oral antifungal considered safe during nursing, but because of the potential for drug accumulation in the nursing infant, experts generally do not recommend antifungal drug therapy during lactation.

The Web site www.doctorfungus.org is an excellent source of information for medical professionals about fungal diseases and treatment.

(Ky.).

COPYRIGHT 2004 International Medical News Group
COPYRIGHT 2004 Gale Group

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