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Isotretinoin is a generic medication used for the treatment of severe acne and most commonly known under the brands Accutane and Roaccutane. It is a retinoid, meaning it is derived from vitamin A and is found naturally in the body, produced by the liver in small quantities. more...

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History

Prior to the development of isotretinoin, the mainstay treatment of severe acne was oral antibiotics such as the tetracyclines and erythromycin. While these drugs have proven efficacy, they worked against only one contributing factor of acne, Propionibacterium acnes bacteria. The antibiotics gradually became less effective over time as more resistant strains of the bacterium became prominent.

An early, effective treatment of acne was high doses of the fat soluble vitamin A. At these dose levels (sometimes 500,000 IU per day) effects such as reduced production of sebum and dry hair could be noticed. However the vitamin also had many other prominent side effects which inhibited its widespread use.

The development of the derivative of retinoic acid, isotretinoin (13-cis-retinoic acid), and its release in 1982 by Hoffmann-La Roche was a great step forward in the treatment of acne. The synthetic compound provided better therapeutic benefit than vitamin A, while also producing fewer side effects. In February 2002 Roche's patents for isotretinoin expired, there are now many other companies selling cheaper generic versions of the drug.

Today isotretinoin is usually prescribed after other acne treatments have failed to produce results. The treatment of acne usually begins with topicals, moves onto oral antibiotics (or a combination) and finally isotretinoin therapy. This is because other treatments, while less effective than isotretinoin, produce far fewer side effects.

Brand names

Isotretinoin is produced under many brand names by many manufacturers. It is available typically as 5 mg, 10 mg, 20 mg and (in the USA) 40 mg capsules.

Some brands of isotretinoin include:

  • Accure® by Alphapharm
  • Accutane® and Roaccutane® by Roche
  • Aknenormin® by Hermal
  • Amnesteem® by Mylan
  • Ciscutan® by Pelpharma
  • Claravis® by Barr
  • Isohexal® by Hexal Australia
  • Isotroin® by Cipla
  • Oratane® by Douglas Pharmaceuticals
  • Sotret® by Ranbaxy

Indications

Isotretinoin is indicated for treatment for a number of dermatological conditions, most commonly acne. It is generally not used as a first-line treatment due to the potential side effects. Antibiotics (such as the tetracyclines) are usually prescribed before isotretinoin.

Severe forms of acne (conglobata, fulminans and nodulocystic) as well as acne that scars can be successfully treated with isotretinoin.

Acne that has not responded to other treatment will usually respond to isotretinoin. Dysmorphophobic patients may also be prescribed isotretinoin.

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Accrue Hit List 4.6 Gives E-Businesses a Worldwide View of Their Web Initiatives
From Business Wire, 8/8/00

Business Editors/High-Tech Writers

FREMONT, Calif.--(BUSINESS WIRE)--Aug. 8, 2000

New Release Offers Unparalleled Analytic Power, Flexibility

and Scalability Across All Windows Environments

Accrue(R) Software, Inc. (Nasdaq:ACRU), the leading provider of eBusiness analytic solutions for optimizing visitor response to Web-based Campaign, Content, Commerce, and Affiliate initiatives today announced Accrue Hit List 4.6. Accrue Hit List enables eBusinesses to rapidly acquire insight on customers from information gathered and analyzed across the enterprise to promote strong customer relationships required to succeed in the Net economy.

Accrue Hit List 4.6 includes full Windows 2000 support, a multi-platform Administration and Report client, and significantly increased capacity to handle the ever-increasing volumes of traffic from growing successful Web sites. By adding full support for Windows 2000, this release furthers Accrue's offering as the most flexible, Windows-compliant analytic package available today. The new cross-platform (Windows 95, 98, 2000 and NT) Hit List Administration and Reporting client provides convenient deployment throughout the enterprise. Other new features build upon Hit List's support for international date formats, localized versions of reports, and scalability enhancements. With Hit List 4.6, enterprises can confidently adopt Hit List as their worldwide Web site analytic solution.

"With the introduction of Hit List 4.6, Accrue is building upon the internationalization support delivered in previous releases to expand platform options, reporting options, and scalability," said Vito Salvaggio, VP of marketing at Accure Software. "This release solidifies Hit List's market position as the analytic solution of choice for enterprises who have chosen to deploy Windows NT-based systems."

Accrue Hit List is already deployed by leading business-to-consumer and business-to-business enterprises including KBKids.com LLC, Thrifty Car Rental, Lending Tree.com, Webvan Group, Wingspan Bank, Bausch & Lomb, Baan USA, Buy.co.uk, Texas Instruments, and El Mercurio.

Price and Availability

Hit List 4.6 will be available in August 2000. The total price varies based on the customer's environment, Web server and network configuration, and training and installation requirements.

About Accrue Software

Accrue Software is the leading provider of eBusiness analytic solutions for optimizing visitor response to Web-based campaign, content, commerce and affiliate initiatives. Accrue's complete line of analytic applications offers companies the ability to target their most profitable customers by understanding behavior and purchasing trends for different visitor segments: Converting Clicks to Customers(TM).

Accrue Software was founded in 1996 and has its headquarters in Fremont, Calif., with regional sales offices throughout the U.S., and an international office in London, England. Accrue has strategic partnerships with Annuncio, Art Technology Group, ABC Interactive, BroadVision, DoubleClick, IBM, Informix, Intel/iPivot, JDA, MarketFirst, MicroStrategy, OgilvyOne Interactive, Open Market, Oracle Corporation, Siebel, Unica, Vignette, and Xchange. Accrue Software can be reached at 888/4ACCRUE or 510/580-4500 and at http:\\www.accrue.com.

Note to Editors: Accrue, Accrue Insight, Hit List, Vista, BuyPath, DataLink, Decision Series and NeoVista Assort and Profile are trademarks of Accrue Software, Inc. All other trademarks are the sole property of their respective owners.

COPYRIGHT 2000 Business Wire
COPYRIGHT 2000 Gale Group

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