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Alosetron

Alosetron is a 5-HT3 antagonist used for the management of severe diarrhoea-predominant irritable bowel syndrome (IBS) in women only. It was withdrawn from the market in 2000 owing to the occurrence of serious life-threatening gastrointestinal adverse effects, but was reintroduced in 2002 with availability and use restricted. It is currently marketed by GlaxoSmithKline under the trade name Lotronex. more...

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Mode of action

Alosetron, while being a 5-HT3 antagonist like ondansetron, is not an antiemetic. Alosetron has an antagonist action on the 5-HT3 receptors of the enteric nervous system of the gastrointestinal tract.

Serious adverse effects

Alosetron was withdrawn in 2000 following the association of alosetron with serious life-threatening gastrointestinal adverse effects.

The cumulative incidence of ischaemic colitis was 2 in 1000, while serious complications arising from constipation (obstruction, perforation, impaction, toxic megacolon, secondary colonic ischaemia, death) was 1 in 1000 (GlaxoSmithKline, 2002).

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Drug for severe IBS will be reintroduced in risk program. (Restrictions in Place for Lotronex).(irritable bowel syndrome) : An article from: Family Practice News $5.95 Risk management program for Lotronex on track: the program may deter physicians from prescribing the IBS drug, the manufacturer tells an FDA panel.(Rx) : An article from: Internal Medicine News $5.95
FDA panel hears update on alosetron risk management: no deaths linked to Lotronex reported.(Women's Health) : An article from: Family Practice News $5.95

FDA approval of alosetron re-introduction - Lotronex - Brief Article
The U.S. Food and Drug Administration (FDA) approved the re-introduction of alosetron hydrochloride (Lotronex) under restricted conditions of use. According to the manufacturer, alosetron will be
From American Family Physician, 8/1/02 by Brian Torrey
Alosetron's Withdrawal Leaves Void for IBS Patients
The recent withdrawal of alosetron (Lotronex) from the marketplace will be a setback for a sizable number of patients with irritable bowel syndrome, ...
From Family Pratice News, 12/15/00 by Bruce Jancin
Revised Labeling Issued for IBS Drug Alosetron
ROCKVILLE, MD. -- The manufacturer of the irritable bowel syndrome drug alosetron has issued a warning about the risks of ischemic colitis and severe ...
From Family Pratice News, 10/1/00 by Elizabeth Mechcatie
Alosetron: A new therapy for irritable bowel syndrome
Irritable bowel syndrome (IBS) is a common functional bowel disorder that is characterized by visceral hypersensitivity and hyperactivity of the gastrointestinal ...
From Nurse Practitioner, 7/1/00 by Kupecz, Deborah
Alosetron Eases IBS Pain - Statistical Data Included - Brief Article
The serotonin receptor inhibitor alosetron effectively lessened the symptoms of irritable bowel syndrome in women, said Dr. Michael Camilleri of the ...
From Family Pratice News, 6/1/00
Pediatric Use for Alosetron to Be Studied - Brief Article - Statistical Data Included
Glaxo Wellcome plans to study alosetron in children and adolescents with irritable bowel syndrome. At the advisory committee hearing, Dr. George Dukes ...
From Family Pratice News, 1/1/00
Drugs, pregnancy, and lactation: GI agents: part I
Gastrointestinal complaints are common in pregnancy and the postpartum period. They include conditions such as nausea and vomiting, constipation, diarrhea, ...
From OB/GYN News, 11/15/05 by Gerald G. Briggs
Clinical quiz
Clinical is for one year Quiz questions are based on selected articles in this issue of American Family Physician. Answers appear in this issue. AFP ...
From American Family Physician, 2/1/05

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