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Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) widely marketed under various trademarks including Act-3, Advil, Brufen, Motrin, Nuprin, and Nurofen; a standing joke about some athletes' regular use has produced "Vitamin I" as a slang term for it. It is used for relief of symptoms of arthritis, primary dysmenorrhoea, and fever; and as an analgesic, especially where there is an inflammatory component. Ibuprofen was developed by the research arm of Boots Group. more...

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Clinical use

Low doses of ibuprofen (200 mg, and sometimes 400 mg) are available over the counter (OTC) in most countries. Ibuprofen has a dose-dependent duration of action of approximately 4–8 hours, which is longer than suggested by its short half-life. The recommended dose varies with body mass and indication. Generally, the oral dose is 200–400 mg (5–10 mg/kg in children) every 4–6 hours, up to a usual maximum daily dose of 800–1200 mg. Under medical direction, a maximum daily dose of 3200 mg may sometimes be used.

Indications

Approved clinical indications for ibuprofen include:

Rheumatoid arthritis (DMARDs should also be considered)
Osteoarthritis, ibuprofen can reduce pain and, if present, joint inflammation
Juvenile rheumatoid arthritis, alone or with corticosteroids
Morbus Bechterew (spondylitis ankylosans) together with corticosteroids
Rheumatic fever, together with antibiotic therapy
Acute gout attack, ibuprofen is not useful for chronic treatment
Primary dysmenorrhoea (ibuprofen proved superior to placebo and propoxyphen, and at least as effective as aspirin)
Fever
Pericarditis, chiefly after myocardial infarction, to reduce pain, fever and inflammation
Minor aches and pains such as toothache, backache, fever and pain associated with common flu, symptomatic relief of influenza, shingles, and postoperative pain
Sporting injuries and pain after mild to moderate trauma
Headache including mild to moderate migraine attack

Off-Label and investigational use

As with other NSAIDs, ibuprofen may be useful in the treatment of severe orthostatic hypotension (PMID 7041104)
In some studies, ibuprofen showed superior results compared to placebo in the prophylaxis of Alzheimer's disease, when given in low doses over a long time (PMID 16195368). Further studies are needed to confirm the results, before ibuprofen can be recommended for this indication.
Ibuprofen has been associated with a lower risk of Parkinson's disease, and may delay or prevent Parkinson's disease. Aspirin, other NSAIDs, and acetaminophen had no effect on the risk for Parkinson's (PMID 16240369). Further research is warranted before recommending ibuprofen for this use.

Ibuprofen lysine

In Europe and Australia, ibuprofen lysine (ibuprofenlysinat, the lysine salt of ibuprofen) is licensed for treatment of the same conditions as ibuprofen. Ibuprofen lysine is said to have a more rapid onset of action compared to base ibuprofen.

Mechanism of action

Ibuprofen is an NSAID which is believed to work through inhibition of cyclooxygenase (COX); thus inhibiting prostaglandin synthesis. As with other NSAIDs, ibuprofen inhibits platelet aggregation, but is not used therapeutically for this action since it is a minor and reversible effect.

Read more at Wikipedia.org

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Are you making the healthiest choices?
From Shape, 10/1/04

Every day, you make choices about your health and well--being. But are you making the right ones? Take another look at some of the decisions you face each day, and see if your choices are the best ones for you and your body.

The Breakfast Club

It's been called "the most important meal of the day"--but chances are your breakfast is overlooked, or skipped altogether. Some food for thought: missing meals can lead to overeating later in the day and weight gain. So eat up and choose wisely--go for whole grains and proteins for energy and sharpened focus.

Work It Out

Can't find time to exercise? You've got choices. Opt for a morning workout--you'll fit in fitness and gain energy for the day. If you still can't swing it, make the choice to exercise whenever you can--take the stairs instead of the elevator, or get off the bus a few stops early and walk the rest of the way to work.

Be Choosy ... in Love and in Birth Control

Whether you're choosing the right guy or looking for a pill that works best for you, your needs are unique. Not all birth control pills are the same, either--and, with more than 40 pills to choose from, it's important to make the choice that is best for you.

Yasmin[R] is a low-dose birth control pill that is more than 99% effective at preventing pregnancy. Yasmin can help:

* Give you shorter, lighter periods

* Reduce cramps

* Regulate your cycle

Know your body, know your mind and know your choices!

Talk to your healthcare provider about Yasmin and see the important safety information on the opposite page.

Learn more at www.yasmin.com

RELATED ARTICLE: The Yasmin "Choices" Sweepstakes

Go to Shape.com and find out if you're making the right choices for you-and you will be automatically entered to win a "choice" night out on the town! Four grand prize winners will each receive a romantic dinner for two, tickets for two to a show, concert or event and his and hers workout gear brought to you by Yasmin, For complete rules go to Shape.com.

Important safety information about Yasmin:

What makes Yasmin[R] different from other birth control pills?

It contains a different kind of progestin which may increase potassium. For healthy women this is not a problem.

How can you be sure Yasmin is safe for you?

Consult your doctor. You should not take Yasmin if you have kidney, liver or adrenal disease because this could cause serious heart and health problems.

What drugs could interfere with Yasmin?

Potassium-increasing drugs. Tell your doctor if you are on daily, long-term treatment for a chronic condition with any of the following: NSAIDs-ibuprofen (Motrin[R], Advil[R]), naproxen (Naprosyn[R], Aleve[R], and others) when taken long-term and daily for arthritis or other diseases or conditions, potassium-sparing diuretics (spironolactone and others), potassium supplementation, ACE inhibitors (Capoten[R], Vasotec[R], Zestril[R], and others). Angiotensin-II receptor antagonists (Cozaar[R], Diovan[R], Avapro[R], and others), and Heparin. Women who take any of the preceding drugs every day should have their potassium level checked in the first month of taking Yasmin.

What are the risks involved with taking any oral contraceptive (OC)?

OCs can be associated with increased risks of several serious side effects, and do not protect against HIV infection or other STDs. Women, particularly those 35 and over, are strongly advised not to smoke due to the risk of serious cardiovascular side effects.

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