Molecular structure of salbutamol
Find information on thousands of medical conditions and prescription drugs.

Airomir

Salbutamol (INN) or albuterol (USAN) is a short-acting β2-adrenergic receptor agonist used for the relief of bronchospasm in conditions such as asthma and COPD. The name Albuterol comes from Salbutamol aerosol. more...

Home
Diseases
Medicines
A
8-Hour Bayer
Abacavir
Abamectin
Abarelix
Abciximab
Abelcet
Abilify
Abreva
Acamprosate
Acarbose
Accolate
Accoleit
Accupril
Accurbron
Accure
Accuretic
Accutane
Acebutolol
Aceclidine
Acepromazine
Acesulfame
Acetaminophen
Acetazolamide
Acetohexamide
Acetohexamide
Acetylcholine chloride
Acetylcysteine
Acetyldigitoxin
Aciclovir
Acihexal
Acilac
Aciphex
Acitretin
Actifed
Actigall
Actiq
Actisite
Actonel
Actos
Acular
Acyclovir
Adalat
Adapalene
Adderall
Adefovir
Adrafinil
Adriamycin
Adriamycin
Advicor
Advil
Aerobid
Aerolate
Afrinol
Aggrenox
Agomelatine
Agrylin
Airomir
Alanine
Alavert
Albendazole
Alcaine
Alclometasone
Aldomet
Aldosterone
Alesse
Aleve
Alfenta
Alfentanil
Alfuzosin
Alimta
Alkeran
Alkeran
Allegra
Allopurinol
Alora
Alosetron
Alpidem
Alprazolam
Altace
Alteplase
Alvircept sudotox
Amantadine
Amaryl
Ambien
Ambisome
Amfetamine
Amicar
Amifostine
Amikacin
Amiloride
Amineptine
Aminocaproic acid
Aminoglutethimide
Aminophenazone
Aminophylline
Amiodarone
Amisulpride
Amitraz
Amitriptyline
Amlodipine
Amobarbital
Amohexal
Amoxapine
Amoxicillin
Amoxil
Amphetamine
Amphotec
Amphotericin B
Ampicillin
Anafranil
Anagrelide
Anakinra
Anaprox
Anastrozole
Ancef
Android
Anexsia
Aniracetam
Antabuse
Antitussive
Antivert
Apidra
Apresoline
Aquaphyllin
Aquaphyllin
Aranesp
Aranesp
Arava
Arestin
Arestin
Argatroban
Argatroban
Argatroban
Argatroban
Arginine
Arginine
Aricept
Aricept
Arimidex
Arimidex
Aripiprazole
Aripiprazole
Arixtra
Arixtra
Artane
Artane
Artemether
Artemether
Artemisinin
Artemisinin
Artesunate
Artesunate
Arthrotec
Arthrotec
Asacol
Ascorbic acid
Asmalix
Aspartame
Aspartic acid
Aspirin
Astemizole
Atacand
Atarax
Atehexal
Atenolol
Ativan
Atorvastatin
Atosiban
Atovaquone
Atridox
Atropine
Atrovent
Augmentin
Aureomycin
Avandia
Avapro
Avinza
Avizafone
Avobenzone
Avodart
Axid
Axotal
Azacitidine
Azahexal
Azathioprine
Azelaic acid
Azimilide
Azithromycin
Azlocillin
Azmacort
Aztreonam
B
C
D
E
F
G
H
I
J
K
L
M
N
O
P
Q
R
S
T
U
V
W
X
Y
Z

Salbutamol sulfate is usually given by the inhaled route for direct effect on bronchial smooth muscle. This is usually achieved through a metered-dose inhaler (MDI) or nebuliser; but other delivery devices marketed for salbutamol sulfate include the Rotahaler, Easyhaler, Diskhaler, and Autohaler. Salbutamol can also be given orally (Volmax®) or intravenously.

Salbutamol became available in the United Kingdom in 1969 and in the United States in 1980 under the brand name Ventolin.

Clinical use

Salbutamol is specifically indicated in the following conditions:

  • acute asthma
  • symptom relief during maintenance therapy of asthma and other conditions with reversible airways obstruction (including COPD)
  • protection against exercise-induced asthma
  • certain conditions involving hyperkalemia

As a β2-agonist, salbutamol also finds use in obstetrics. Intravenous salbutamol can be used as a tocolytic to relax the uterine smooth muscle to delay premature labour. Whilst preferred over agents such as atosiban and ritodrine, its role has largely been replaced by the calcium-channel blocker nifedipine which is more effective, better tolerated and orally administered. (Rossi, 2004)

Mode of action

As with other β2-adrenergic receptor agonists, salbutamol binds to β2-adrenergic receptors with a higher affinity than β1-receptors. In the airways, activation of β2-receptors results in relaxation of bronchial smooth muscle. resulting in a widening of the airway (bronchodilation). Inhaled salbutamol sulfate has a rapid onset of action, providing relief within 5-15 minutes of administration.

In tocolysis, the activation of β2-receptors results in relaxation of uterine smooth muscle, thus delaying labour.

Adverse effects

Whilst salbutamol is well-tolerated, particularly when compared with previous therapies such as theophylline, like all medications there exists the potential for adverse drug reactions to occur - especially when in high doses, or when taken orally or intravenously.

Common adverse effects include: tremor, palpitations and headache. (Rossi, 2004)

Infrequent adverse effects include: tachycardia, muscle cramps, agitation, hypokalemia, hyperactivity in children, and insomnia. (Rossi, 2004)

Other brand names

Salbutamol is sold under the brand names Airomir, Asmol, Buventol, Proventil, Sultanol, Ventolin and Volmax.

Read more at Wikipedia.org


[List your site here Free!]


IVAX Expands Respiratory Products Franchise in Europe
From Business Wire, 7/15/03

Business Editors/Health/Medical Writers

MIAMI--(BUSINESS WIRE)--July 15, 2003

IVAX Corporation (AMEX:IVX)(LSE:IVX.L) has agreed to assume exclusive rights to 3M Company's (NYSE:MMM) branded respiratory products, together with related marketing and sales people in nine European countries: United Kingdom, Ireland, France, Germany, Netherlands, Finland, Denmark, Norway and Sweden. The agreement covers the products QVAR(R) (HFA beclomethasone dipropionate), Airomir(R) (HFA salbutamol) in Autohaler(R) and MDI devices, and over 200 professionals to market and sell these products.

Neil Flanzraich, IVAX Corporation vice chairman and president, said, "This transaction complements IVAX' growing strength in the global respiratory products market. Additionally, these products, along with the marketing and sales infrastructure, will expand IVAX' presence in several strategically important countries and provide a robust platform for IVAX' rich and diverse product pipeline."

Dr. Charles Reich, executive vice president, 3M Health Care Business said, "This agreement with IVAX is a continuation of our global strategy to participate in the respiratory market through alliances, while focusing 3M's research and commercial resources on our new Immune Response Modifier compounds. It further strengthens our position as a leading supplier of innovative drug delivery systems, pharmaceuticals, medical supplies and dental materials that benefit patients and health care professionals worldwide."

In April 2002, IVAX obtained exclusive U.S. rights to QVAR, currently the only CFC-free (free of chlorofluorocarbons that deplete atmospheric ozone) aerosol corticosteroid on the U.S. market to treat asthma. QVAR delivers its medication in small particles (1.1 microns versus 3+ microns for other orally-inhaled steroids) for greater drug deposition in the small as well as intermediate and large airways of the lung. IVAX' sales of QVAR in the U.S. have shown substantial growth.

QVAR, a CFC-free aerosol corticosteroid, is a "maintenance" medication used to prevent asthma attacks. Airomir, which contains salbutamol (known in the U.S. as albuterol), is a "rescue" medication to relieve acute asthma symptoms. Its HFA formulation means that it also is CFC-free. IVAX and 3M have been world leaders in developing and marketing CFC-free inhaler devices.

IVAX welcomes and values the knowledge and skills of the sales, marketing and support professionals joining IVAX.

3M will continue to manufacture and supply these products to IVAX and provide transitional services for twelve months. The transaction is pending regulatory and other approvals and completion of an employee consultation process.

About 3M

3M is a $16 billion diversified technology company with leading positions in consumer and office; display and graphics; electronics and telecommunications; health care; industrial; safety, security and protection services; transportation and other businesses. Headquartered in St. Paul, Minnesota, the company has operations in more than 60 countries and serves customers in nearly 200 countries. 3M is one of the 30 stocks that make up the Dow Jones Industrial Average and also is a component of the Standard & Poor's 500 Index. For more information about 3M, go to http://www.3m.com.

About IVAX

IVAX Corporation, headquartered in Miami, Florida, discovers, develops, manufactures, and markets branded and brand equivalent (generic) pharmaceuticals and veterinary products in the U.S. and abroad. IVAX has direct operations in more than 30 countries and its products are sold in more than 80 countries.

Copies of this and other news releases may be obtained free of charge from IVAX' website at http://www.ivax.com.

This press release contains certain forward-looking statements by IVAX regarding product development efforts, growth prospects, product performance and other non-historical facts which are being are made pursuant to the safe harbor provisions of the Private Securities Litigation Reform Act of 1995. These statements involve risks and uncertainties that cannot be predicted or quantified and, consequentially, actual results may differ materially from those expressed or implied by such forward-looking statements. Such risks and uncertainties include, among others, that the transaction with 3M will not expand IVAX' presence in any country, will not provide a platform or otherwise support IVAX' product pipeline, and will not strengthen IVAX' position in the global asthma product market, that IVAX' position in the global asthma product market will not grow; that QVAR may not prove to have the perceived advantages over other available inhaled asthma products; that IVAX' sales of QVAR will not continue to grow and may decrease; changing market conditions; that the compounds and products in IVAX' pipelines will not be successfully developed, will not receive regulatory approval or will not be successfully commercialized; the impact of competitive products and pricing; the impact of foreign currency exchange rates and fluctuations in those rates; and timely and satisfactory completion of the employee consultation process and timely receipt of regulatory and other approvals of the transactions described herein and satisfaction of all conditions. In addition to the risk factors set forth above, IVAX' forward looking statements may also be adversely affected by general market factors, competitive product development, product availability, manufacturing issues that may arise, trade buying patterns, patent positions and litigation, among other things. For further details and discussion of these and other risks and uncertainties, see IVAX' Annual Report on Form 10-K and other filings with the Securities and Exchange Commission.

COPYRIGHT 2003 Business Wire
COPYRIGHT 2003 Gale Group

Return to Airomir
Home Contact Resources Exchange Links ebay