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Altace

Ramipril (marketed as TritaceĀ® or AltaceĀ®) is an angiotensin converting enzyme (ACE) inhibitor, used to treat high blood pressure and congestive heart failure. ACE inhibitors lower the production of Angiotensin II, therefore relaxing arterial muscles while at the same time enlarging the arteries, allowing the heart to pump blood easier, and increasing blood flow due to more blood being pumped into and through bigger passageways. more...

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Ramipril is a prodrug and is converted to the active metabolite ramiprilat by liver esterase enzymes. Ramiprilat is mostly excreted by the kidneys. The half-life of ramiprilat is variable (3 - 16 hours), and is prolonged by heart and liver failure, as well as kidney failure.

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Altace fights stroke in diabetes - recommended by Stroke Council of American Heart Association - Brief Article
From Drug Store News, 2/19/01

Guidelines issued by the Stroke Council of the American Heart Association and published in Circulation and Stroke recommend use of Altace (ramipril) in people with diabetes who are at risk for stroke. These recommendations are based on the Heart Outcomes Prevention Evaluation study, which showed that people with diabetes can reduce their risk of stroke by 33 percent, even if they are taking other medications. People with diabetes are two to four times more likely to suffer from heart disease. Altace, an ACE inhibitor, is marketed by Monarch Pharmaceuticals.

COPYRIGHT 2001 Lebhar-Friedman, Inc.
COPYRIGHT 2001 Gale Group

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